{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nMiR‐760 has emerged as an important regulatory non‐coding RNA across a broad spectrum of diseases, most notably in cancer. Multiple independent studies have consistently shown that miR‐760 is downregulated in several malignancies—including colorectal, non‐small cell lung, hepatocellular, gastric, prostate, esophageal, pancreatic, and glioma—where its reduced expression correlates with advanced tumor stage, increased chemoresistance, and poor clinical outcomes. In several reports, serum levels of miR‐760 exhibited promising diagnostic and prognostic potential, suggesting its value as a non‐invasive biomarker in cancers such as colorectal and non‐small cell lung cancer, as well as in conditions like polycystic ovary syndrome."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "16"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nAt the mechanistic level, miR‐760 exerts its tumor‐suppressive effects through direct targeting of several key oncogenic transcripts and signaling pathways. In non‐small cell lung cancer, for example, miR‐760 downregulates the proto‐oncogene ROS1 and, in a related study, its overexpression was shown to enhance the sensitivity of cancer cells to TRAIL‐induced apoptosis by targeting FOXA1. In hepatocellular carcinoma, miR‐760 impedes doxorubicin resistance by inhibiting Notch1 signaling, while in pulmonary arterial hypertension it curtails smooth muscle cell proliferation through direct regulation of Toll‐like receptor 4. Other investigations indicate that miR‐760 can modulate chemoresponse and proliferative signaling via its inhibitory effects on MOV10‐stabilized ITGB1 in pancreatic cancer, target c‐Myc and downstream metabolic enzymes in esophageal squamous cell carcinoma, as well as suppress tumor growth through downregulation of BST2 in gastric cancer and NACC‐1 in hepatocellular carcinoma. In addition, by targeting interleukin‐6 and modulating immune evasion via IDO1, miR‐760 also appears to impact the tumor microenvironment."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "5", "end_ref": "8"}, {"type": "fg_fs", "start_ref": "17", "end_ref": "19"}, {"type": "fg_f", "ref": "11"}, {"type": "fg_f", "ref": "14"}, {"type": "fg_f", "ref": "20"}, {"type": "fg_f", "ref": "15"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond these cell‐intrinsic mechanisms, miR‐760 is also subject to regulation by several long non‐coding RNAs acting as competing endogenous RNAs (ceRNAs), which sequester and functionally inhibit miR‐760 activity. For instance, in glaucoma, the lncRNA NR_003923 has been shown to bind miR‐760, affecting downstream IL22RA1 expression and modulating fibroblast behavior; similarly, in non‐small cell lung cancer, LINC01561 sponges miR‐760 to regulate SHCBP1. In other contexts, such as osteoporosis and cellular senescence/anti‐aging, dysregulation of the ceRNA networks involving lncRNAs like LINC00963 and KCNQ1OT1 leads to altered miR‐760 availability and consequent changes in targets such as ETS1 and CK2α, thereby impacting osteogenic differentiation and the cellular aging process."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "21", "end_ref": "26"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Young-Hoon Lee, Soo Young Kim, Young-Seuk Bae "}, {"type": "b", "children": [{"type": "t", "text": "Upregulation of miR-760 and miR-186 is associated with replicative senescence in human lung fibroblast cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cells (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.14348/molcells.2014.0157"}], "href": "https://doi.org/10.14348/molcells.2014.0157"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25139266"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25139266"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Jianxin Lv, Ziyi Fu, Min Shi, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "circPUM1 promotes polycystic ovary syndrome progression by sponging to miR-760."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Gene (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.gene.2020.144903"}], "href": "https://doi.org/10.1016/j.gene.2020.144903"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32540374"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32540374"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Xiao-Hong Su, Yan-Rong Zhu, Yun-Jiao Hou, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Histocompatibility Minor 13 (HM13), targeted by miR-760, exerts oncogenic role in breast cancer by suppressing autophagy and activating PI3K-AKT-mTOR pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Death Dis (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41419-022-05154-4"}], "href": "https://doi.org/10.1038/s41419-022-05154-4"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36153332"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36153332"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Ahmed E Abd El-Aal, Ahmed Elshafei, Maha Y Ismail, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of miR-106b-5p, miR-601, and miR-760 Expression and Their Clinical Values in Non-Small Cell Lung Cancer (NSCLC) Patients' Serum."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Pathol Res Pract (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.prp.2023.154663"}], "href": "https://doi.org/10.1016/j.prp.2023.154663"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37429174"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37429174"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Dejun Yang, Zunqi Hu, Jiapeng Xu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MiR-760 enhances sensitivity of pancreatic cancer cells to gemcitabine through modulating Integrin β1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biosci Rep (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1042/BSR20192358"}], "href": "https://doi.org/10.1042/BSR20192358"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31693728"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31693728"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Xuetao Yang, Cheng Zhang, Hongtao Tie, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-760 exerts an antioncogenic effect in esophageal squamous cell carcinoma by negatively driving fat metabolism via targeting c-Myc."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biochem (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcb.29540"}], "href": "https://doi.org/10.1002/jcb.29540"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31709636"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31709636"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Linan Yin, Tingting Sun, Ruibao Liu "}, {"type": "b", "children": [{"type": "t", "text": "NACC-1 regulates hepatocellular carcinoma cell malignancy and is targeted by miR-760."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Acta Biochim Biophys Sin (Shanghai) (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/abbs/gmz167"}], "href": "https://doi.org/10.1093/abbs/gmz167"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32091103"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32091103"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Hong Ge, Lili Wang, Wenqiang Chen, et al. 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