MIR762 Gene

HGNC Family Non-coding RNAs
Name microRNA 762
Description microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Summary
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nMicroRNA‐762 (miR-762) acts as a key regulator in distinct cellular contexts. In placental tissue, miR-762 normally promotes trophoblast cell migration and epithelial–mesenchymal transition (EMT), processes that become dysregulated in pre‐eclampsia; here, elevated levels of specific circular RNAs (e.g., circTNRC18) sequester miR-762 resulting in increased expression of EMT‐related factors. In parallel, exposure of corneal epithelial cells to tear fluid upregulates miR-762, which in turn suppresses innate defense molecules such as RNase7, ST2, and Rab5a that are critical for inhibiting bacterial invasion."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn the arena of tumorigenesis, miR-762 has been implicated in multiple cancer types. Its expression is under investigation in breast cancer, suggesting oncogenic roles that may contribute to tumor progression. In urothelial carcinoma of the bladder, miR-762 is regulated by circular RNAs (such as circFAM114A2) that act as competing endogenous RNAs to modulate TP63 isoform levels, thereby affecting cell migration, invasion, and proliferation. Furthermore, increased miR-762 levels have been associated with gefitinib resistance in non-small-cell lung cancer (NSCLC), and circulating levels of this microRNA are emerging as promising diagnostic and prognostic biomarkers in NSCLC patients."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "3", "end_ref": "6"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its roles in developmental and cancer-related processes, miR-762 also contributes to inflammatory pathology. In severe acute lung injury, miR-762 is notably upregulated, leading to the suppression of NFIX. This suppression augments NF-κB and IRF3 signaling pathways and elevates the production of pro-inflammatory cytokines, thus exacerbating inflammation and tissue damage in the lung. These observations highlight the therapeutic potential of targeting the miR-762/NFIX axis in inflammatory lung diseases."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "James Mun, Connie Tam, Gary Chan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-762 is upregulated in human corneal epithelial cells in response to tear fluid and Pseudomonas aeruginosa antigens and negatively regulates the expression of host defense genes encoding RNase7 and ST2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0057850"}], "href": "https://doi.org/10.1371/journal.pone.0057850"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23469087"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23469087"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Xue-Yan Shen, Li-Li Zheng, Jing Huang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "CircTRNC18 inhibits trophoblast cell migration and epithelial-mesenchymal transition by regulating miR-762/Grhl2 pathway in pre-eclampsia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "RNA Biol (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/15476286.2019.1644591"}], "href": "https://doi.org/10.1080/15476286.2019.1644591"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31354028"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31354028"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Yongping Li, Ruixue Huang, Ling Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "microRNA-762 promotes breast cancer cell proliferation and invasion by targeting IRF7 expression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Prolif (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/cpr.12223"}], "href": "https://doi.org/10.1111/cpr.12223"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26597380"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26597380"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Peng Ge, Lei Cao, Xin Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-762 activation confers acquired resistance to gefitinib in non-small cell lung cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "BMC Cancer (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12885-019-6416-4"}], "href": "https://doi.org/10.1186/s12885-019-6416-4"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31823748"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31823748"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Tianyao Liu, Qun Lu, Jin Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Circular RNA FAM114A2 suppresses progression of bladder cancer via regulating ∆NP63 by sponging miR-762."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Death Dis (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41419-020-2226-5"}], "href": "https://doi.org/10.1038/s41419-020-2226-5"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31969560"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31969560"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Lei Chen, Yunxia Li, Jingshu Lu "}, {"type": "b", "children": [{"type": "t", "text": "Identification of Circulating miR-762 as a Novel Diagnostic and Prognostic Biomarker for Non-Small Cell Lung Cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Technol Cancer Res Treat (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1177/1533033820964222"}], "href": "https://doi.org/10.1177/1533033820964222"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33317398"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33317398"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Xiao-Long Zhang, Jian An, Yong-Zhi Deng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A novel miRNA-762/NFIX pathway modulates LPS-induced acute lung injury."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int Immunopharmacol (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.intimp.2021.108066"}], "href": "https://doi.org/10.1016/j.intimp.2021.108066"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34492536"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34492536"}]}]}]}
Synonyms HSA-MIR-762
NCBI Gene ID 100313837
API
Download Associations
Predicted Functions View MIR762's ARCHS4 Predicted Functions.
Co-expressed Genes View MIR762's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View MIR762's ARCHS4 Predicted Functions.

Functional Associations

MIR762 has 2,082 functional associations with biological entities spanning 4 categories (molecular profile, functional term, phrase or reference, cell line, cell type or tissue, gene, protein or microRNA) extracted from 18 datasets.

Click the + buttons to view associations for MIR762 from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq tissue samples with high or low expression of MIR762 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
CCLE Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR762 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
ChEA Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR762 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
ChEA Transcription Factor Targets transcription factors binding the promoter of MIR762 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
COSMIC Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR762 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
ENCODE Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR762 gene from the ENCODE Histone Modification Site Profiles dataset.
ENCODE Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR762 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
ENCODE Transcription Factor Targets transcription factors binding the promoter of MIR762 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
ESCAPE Omics Signatures of Genes and Proteins for Stem Cells PubMedIDs of publications reporting gene signatures containing MIR762 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
GeneRIF Biological Term Annotations biological terms co-occuring with MIR762 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
GTEx Tissue Gene Expression Profiles tissues with high or low expression of MIR762 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles dataset.
GTEx Tissue Sample Gene Expression Profiles tissue samples with high or low expression of MIR762 gene relative to other tissue samples from the GTEx Tissue Sample Gene Expression Profiles dataset.
JASPAR Predicted Transcription Factor Targets transcription factors regulating expression of MIR762 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR762 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles cell lines with high or low expression of MIR762 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles dataset.
MotifMap Predicted Transcription Factor Targets transcription factors regulating expression of MIR762 gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset.
Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles cell types and tissues with high or low DNA methylation of MIR762 gene relative to other cell types and tissues from the Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles dataset.
Roadmap Epigenomics Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR762 gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset.