{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nMicroRNA‐767 (miR-767) represents a multifaceted regulator in human cancer whose activity is highly context-dependent. In some tumors, activation of miR-767—such as that produced from the cancer-germline transcript CT-GABRA3—promotes oncogenesis by repressing the expression of the DNA hydroxymethylases TET1 and TET3, thereby contributing to genome hypomethylation and decreased 5‑hydroxymethylcytosine levels."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In contrast, in human melanoma cells, miR-767 targets the deubiquitinating enzyme CYLD to relieve its inhibitory effect on cell proliferation, thus functioning as a tumor promoter."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn several other malignancies, differential expression of miR-767 strands mediates key aspects of tumor behavior. For instance, in lung adenocarcinoma, downregulation of miR-767-3p permits overexpression of the tight junction component CLDN18, leading to enhanced cell proliferation, migration, and invasion."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " Similarly, in glioblastoma multiforme, forced upregulation of miR-767-5p suppresses cell proliferation and migration through inhibition of the polycomb repressive complex component SUZ12."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": " Additionally, in non-small cell lung cancer, knockdown of circ_0018818 elevates miR-767-3p levels, which in turn downregulates Nidogen 1 (NID1) to inhibit tumor growth and invasion."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": " In gastric cancer, a circRNA-mediated upregulation of miR-767-5p contributes to decreased cell viability and invasiveness, suggestive of a tumor-suppressive role in that context."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nMicroRNA-767 is also intricately involved in hepatocellular carcinoma (HCC) and breast cancer through its interactions with various noncoding RNAs and downstream effectors. In HCC, circ_0000673 acts as a sponge for miR-767-3p, and its silencing leads to reduced proliferation and invasion, evidencing the tumor-suppressive function of miR-767-3p in this setting."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": " Conversely, another study in HCC identified upregulation of miR-767-5p, which promoted aggressive tumor characteristics by directly repressing PMP22"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": ", while dysregulation of a long noncoding RNA (RP11-909N17.2) that binds miR-767-3p further underscores its critical tumor-suppressive role by modulating SMIM7 expression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "9"}]}, {"type": "t", "text": " In breast cancer, downregulated circ_0052611 results in elevated miR-767-5p levels that target SCAI, thereby promoting cell migration, invasion, and metabolic reprogramming characteristic of the Warburg effect."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "10"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Axelle Loriot, Aurélie Van Tongelen, Jordi Blanco, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A novel cancer-germline transcript carrying pro-metastatic miR-105 and TET-targeting miR-767 induced by DNA hypomethylation in tumors."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Epigenetics (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4161/epi.29628"}], "href": "https://doi.org/10.4161/epi.29628"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25089631"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25089631"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Kejin Zhang, Ling Guo "}, {"type": "b", "children": [{"type": "t", "text": "MiR-767 promoted cell proliferation in human melanoma by suppressing CYLD expression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Gene (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.gene.2017.10.055"}], "href": "https://doi.org/10.1016/j.gene.2017.10.055"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29054757"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29054757"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Yi Long Wan, Han Jue Dai, Wei Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-767-3p Inhibits Growth and Migration of Lung Adenocarcinoma Cells by Regulating CLDN18."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncol Res (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3727/096504017X15112639918174"}], "href": "https://doi.org/10.3727/096504017X15112639918174"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29169410"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29169410"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Jiale Zhang, Shuo Xu, Jia Xu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR‑767‑5p inhibits glioma proliferation and metastasis by targeting SUZ12."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncol Rep (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/or.2019.7156"}], "href": "https://doi.org/10.3892/or.2019.7156"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31115583"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31115583"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Xiaohui Xu, Xiaoyun Zhou, Chao Gao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Hsa_circ_0018818 knockdown suppresses tumorigenesis in non-small cell lung cancer by sponging miR-767-3p."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Aging (Albany NY) (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/aging.103089"}], "href": "https://doi.org/10.18632/aging.103089"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32357143"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32357143"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Hanke Geng, Kaixuan Li, Qi Pan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification and Expression of Several Circular RNAs and Knockdown of hsa_circ_0005556 Exerts Oncogenic Functions by miR-767-5p in Gastric Cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Med Sci Monit (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.12659/MSM.921163"}], "href": "https://doi.org/10.12659/MSM.921163"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32728015"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32728015"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Weidong Jiang, Dacheng Wen, Lulu Gong, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Circular RNA hsa_circ_0000673 promotes hepatocellular carcinoma malignance by decreasing miR-767-3p targeting SET."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2018.04.041"}], "href": "https://doi.org/10.1016/j.bbrc.2018.04.041"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29627570"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29627570"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Lei Zhang, Zhimin Geng, Yong Wan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Functional analysis of miR-767-5p during the progression of hepatocellular carcinoma and the clinical relevance of its dysregulation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Histochem Cell Biol (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00418-020-01878-6"}], "href": "https://doi.org/10.1007/s00418-020-01878-6"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32333091"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32333091"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Qiang Liu, She-Jiao Dai, Lei Dong, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long noncoding RNA RP11-909N17.2 promotes proliferation, invasion, and migration of hepatocellular carcinoma by regulating microRNA-767-3p."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Cell Biol (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1139/bcb-2019-0362"}], "href": "https://doi.org/10.1139/bcb-2019-0362"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33210543"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33210543"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Xin Wang, Zongwen Liu, Alan Chu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Hsa_circ_0052611 and mir-767-5p guide the warburg effect, migration, and invasion of BRCA cells through modulating SCAI."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Bioenerg Biomembr (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s10863-023-09985-4"}], "href": "https://doi.org/10.1007/s10863-023-09985-4"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37743442"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37743442"}]}]}]}