MIR769 Gene

HGNC Family Non-coding RNAs
Name microRNA 769
Description microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Summary
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By contrast, in studies of breast cancer cells under hypoxia/reoxygenation conditions, miR‐769-3p was shown to inhibit cell growth and enhance apoptosis through suppression of NDRG1"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": ", and in oral squamous cell carcinoma its downregulation correlates with tumor progression, with restoration of miR‐769-5p impeding the JAK1/STAT3 pathway."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": " In non‐small cell lung cancer, the overexpressed long noncoding RNA LINC00460 contributes to gefitinib resistance by sponging miR‐769-5p, which in turn deregulates EGFR signaling."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn several studies the activity of miR‐769 is modulated by competing endogenous RNAs. In cervical carcinoma, the long noncoding RNA RP11-284F21.9 sequesters miR‐769-3p, leading to altered expression of PPWD1 and impacting cell proliferation and invasion."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": " Similarly, in gastric cancer, HAND2-AS1 functions as a tumor suppressor by sponging miR‐769-5p to relieve repression of TCEAL7"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": ", while in keloid formation, lncRNA H19 relieves miR‐769-5p-mediated inhibition of EIF3A, thereby promoting fibroblast activity."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": " In cervical cancer, a newly identified circular RNA, circ-PGAP3, is transcriptionally induced by p53 and acts as a sponge for miR‐769-5p, ultimately enhancing p53 signaling and suppressing tumorigenesis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "9"}]}, {"type": "t", "text": " Moreover, in bladder cancer, circLOC729852 sequesters miR‐769-5p, resulting in upregulation of IL-10 via the JAK2/STAT3 pathway and promoting an immunosuppressive tumor microenvironment."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "10"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its intracellular roles, miR‐769 holds promise as a biomarker and a mediator in diverse pathological contexts. Plasma levels of miR‐769-5p have been identified as one component in a signature distinguishing tuberculosis patients from healthy individuals"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "11"}]}, {"type": "t", "text": ", and it is included in miRNA signatures for prognostic evaluation in esophageal carcinoma."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "12"}]}, {"type": "t", "text": " In gastric cancer, additional studies have focused on its expression and contribution to chemoresistance"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "13"}]}, {"type": "t", "text": ", while in osteosarcoma miR‐769-5p modulates cell growth through regulation of RARRES1."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "15"}]}, {"type": "t", "text": " Finally, several reports, including investigations in chronic periodontitis"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "16"}]}, {"type": "t", "text": "and colorectal cancer"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "17"}]}, {"type": "t", "text": ", hint at broader yet still incompletely defined roles for miR‐769 within diverse disease settings."}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Hai-Jiang Qiu, Xiao-He Lu, Sha-Sha Yang, et al. 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Synonyms MIRN769, HSA-MIR-769, MIR-769
NCBI Gene ID 768217
API
Download Associations
Predicted Functions View MIR769's ARCHS4 Predicted Functions.
Co-expressed Genes View MIR769's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View MIR769's ARCHS4 Predicted Functions.

Functional Associations

MIR769 has 585 functional associations with biological entities spanning 4 categories (molecular profile, functional term, phrase or reference, cell line, cell type or tissue, gene, protein or microRNA) extracted from 14 datasets.

Click the + buttons to view associations for MIR769 from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
CCLE Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR769 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
ChEA Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR769 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
ChEA Transcription Factor Targets transcription factors binding the promoter of MIR769 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
COSMIC Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR769 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
ENCODE Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR769 gene from the ENCODE Histone Modification Site Profiles dataset.
ENCODE Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR769 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
ENCODE Transcription Factor Targets transcription factors binding the promoter of MIR769 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
GeneSigDB Published Gene Signatures PubMedIDs of publications reporting gene signatures containing MIR769 from the GeneSigDB Published Gene Signatures dataset.
GTEx Tissue Gene Expression Profiles tissues with high or low expression of MIR769 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR769 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.
MiRTarBase microRNA Targets microRNAs targeting MIR769 gene in low- or high-throughput microRNA targeting studies from the MiRTarBase microRNA Targets dataset.
MotifMap Predicted Transcription Factor Targets transcription factors regulating expression of MIR769 gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset.
Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles cell types and tissues with high or low DNA methylation of MIR769 gene relative to other cell types and tissues from the Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles dataset.
Roadmap Epigenomics Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR769 gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset.