MIR7706 Gene

HGNC Family Non-coding RNAs
Name microRNA 7706
Description microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Summary
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRecent investigations into non‐coding RNAs have revealed that circular RNAs serve as critical modulators in tumorigenesis. In this emerging context, MIR7706 has been identified as a potential regulatory molecule in breast cancer, where it may participate in fine‐tuning gene expression networks involved in cell proliferation and programmed cell death."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n \nMIR7706 appears to function either by acting as a molecular scaffold that organizes key interactions among proteins and RNAs or by serving as a decoy that sequesters other microRNAs to modulate downstream signaling pathways. Such roles suggest that aberrant expression of MIR7706 may contribute to oncogenic processes by disrupting cellular homeostasis and promoting tumor progression, thereby holding promise as both a biomarker for early breast cancer detection and a target for therapeutic intervention."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n \nOngoing exploration into circRNAs such as MIR7706 is essential to fully elucidate its molecular mechanisms and impacts on breast cancer biology. A deeper understanding of its regulatory functions will likely pave the way for improved diagnostic and treatment strategies in oncology."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Haoqi Wang, Fei Liu, Jing Xue, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The investigation of circRNA profiling reveals the regulatory role of the hsa_circ_0000375/miR-7706 pathway in breast cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Biol Rep (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s11033-023-08798-3"}], "href": "https://doi.org/10.1007/s11033-023-08798-3"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37904009"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37904009"}]}]}]}
Synonyms HSA-MIR-7706
NCBI Gene ID 102465803
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Predicted Functions View MIR7706's ARCHS4 Predicted Functions.
Co-expressed Genes View MIR7706's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View MIR7706's ARCHS4 Predicted Functions.

Functional Associations

MIR7706 has 0 functional associations with biological entities spanning 0 categories () extracted from 0 datasets.

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Dataset Summary