MIR7846 Gene

HGNC Family Non-coding RNAs
Name microRNA 7846
Description microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Summary
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRecent studies have highlighted that exosomes and their microRNA cargo play essential roles in regulating key cellular processes, such as proliferation and angiogenesis. Drawing parallels from these findings, MIR7846—packaged within exosomes—may similarly modulate gene expression programs that influence cell growth and the formation of new blood vessels. This activity supports its potential involvement in intercellular signaling networks crucial for both normal physiological functions and pathological conditions like cancer progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Di Wu, Xiao Liu, Zhehu Jin "}, {"type": "b", "children": [{"type": "t", "text": "Adipose-derived mesenchymal stem cells-sourced exosomal microRNA-7846-3p suppresses proliferation and pro-angiogenic role of keloid fibroblasts by suppressing neuropilin 2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cosmet Dermatol (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/jocd.15721"}], "href": "https://doi.org/10.1111/jocd.15721"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37025072"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37025072"}]}]}]}
Synonyms HSA-MIR-7846
NCBI Gene ID 102465836
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Predicted Functions View MIR7846's ARCHS4 Predicted Functions.
Co-expressed Genes View MIR7846's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View MIR7846's ARCHS4 Predicted Functions.

Functional Associations

MIR7846 has 0 functional associations with biological entities spanning 0 categories () extracted from 0 datasets.

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Dataset Summary