| HGNC Family | Non-coding RNAs |
| Name | microRNA 7846 |
| Description | microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009] |
| Summary |
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRecent studies have highlighted that exosomes and their microRNA cargo play essential roles in regulating key cellular processes, such as proliferation and angiogenesis. Drawing parallels from these findings, MIR7846—packaged within exosomes—may similarly modulate gene expression programs that influence cell growth and the formation of new blood vessels. This activity supports its potential involvement in intercellular signaling networks crucial for both normal physiological functions and pathological conditions like cancer progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Di Wu, Xiao Liu, Zhehu Jin "}, {"type": "b", "children": [{"type": "t", "text": "Adipose-derived mesenchymal stem cells-sourced exosomal microRNA-7846-3p suppresses proliferation and pro-angiogenic role of keloid fibroblasts by suppressing neuropilin 2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cosmet Dermatol (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/jocd.15721"}], "href": "https://doi.org/10.1111/jocd.15721"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37025072"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37025072"}]}]}]}
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| Synonyms | HSA-MIR-7846 |
| NCBI Gene ID | 102465836 |
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| Predicted Functions |
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| Co-expressed Genes |
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| Expression in Tissues and Cell Lines |
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MIR7846 has 0 functional associations with biological entities spanning 0 categories () extracted from 0 datasets.
Click the + buttons to view associations for MIR7846 from the datasets below.
If available, associations are ranked by standardized value
| Dataset | Summary |
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