{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nStudies have recently elucidated a novel role for miR‑7847‑3p as a key regulator within a competing endogenous RNA network that modulates inflammatory signaling during sepsis. Specifically, miR‑7847‑3p functions by binding to and suppressing expression of protein kinase C gamma (PRKCG), a critical effector within the MAPK cascade. In immune cells exposed to lipopolysaccharide (LPS), the long noncoding RNA IL‑17RA‑1 sequesters miR‑7847‑3p, thereby decreasing its availability and relieving its repression on PRKCG. This de-repression enables enhanced activation of downstream MAPK signaling components (evidenced by increased levels of phosphorylated MEKK1 and JNK), which in turn elevates proinflammatory responses, affecting cell viability and migration. These findings suggest that miR‑7847‑3p normally acts as an anti-inflammatory modulator by targeting PRKCG, and its sequestration via IL‑17RA‑1 contributes to an exacerbated sepsis response."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Yuanxiu Gan, Jie Long, Yan Zeng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "lncRNA IL-17RA-1 Attenuates LPS-Induced Sepsis via miR-7847-3p/PRKCG-Mediated MAPK Signaling Pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mediators Inflamm (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1155/2022/9923204"}], "href": "https://doi.org/10.1155/2022/9923204"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36274974"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36274974"}]}]}]}