{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nAlthough the provided collection of abstracts offers a wide-ranging view of transient receptor potential (TRP) channel functions—most notably those of TRPV1 in nociception, thermoregulation, neurogenic inflammation, metabolic homeostasis, and cellular signaling"}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "4"}]}, {"type": "t", "text": ", there is no discussion or experimental data concerning MIR7848 in any of these reports. Instead, these studies concentrate on elucidating the multifaceted roles of TRPV1 and other TRP channels—for example, demonstrating that TRPV1 contributes to rapid sensitization of nociceptive neurons"}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "5", "end_ref": "10"}]}, {"type": "t", "text": ", and that its activation and modulation are critically involved in sensory perception, inflammatory hyperalgesia, and even metabolic regulation.\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nAdditional reports detail TRPV1 contributions to complex phenomena such as pruritus"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "11"}]}, {"type": "t", "text": ", neuro-immune interactions"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "13"}]}, {"type": "t", "text": ", and the regulation of pancreatic, adipose, and skeletal muscle functions."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "14", "end_ref": "20"}]}, {"type": "t", "text": " These findings extend to central nervous system roles—such as the modulation of fear‐related behavior and synaptic plasticity—as well as to peripheral mechanisms including vascular and bladder sensory functions."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "21", "end_ref": "29"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nMoreover, other studies in this set have expanded the panorama of TRPV1-related biology to include roles in phagocytosis and cell membrane trafficking, as well as its therapeutic exploitation in strategies for obesity, atherosclerosis, and neuropathies."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "30", "end_ref": "36"}]}, {"type": "t", "text": " Similarly, investigations addressing novel modalities of TRPV1 modulation—for instance, via endogenous ligands such as oxidized linoleic acid metabolites or ATP, as well as via engineered nanoparticle systems—further underline the channel’s extensive physiological and therapeutic relevance."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "37", "end_ref": "41"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn sum, while these numerous studies"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "24"}, {"type": "fg_f", "ref": "3"}, {"type": "fg_f", "ref": "42"}, {"type": "fg_f", "ref": "11"}, {"type": "fg_f", "ref": "4"}, {"type": "fg_f", "ref": "43"}, {"type": "fg_f", "ref": "20"}]}, {"type": "t", "text": "collectively advance our understanding of TRPV1 and its associated cellular pathways in sensory neuron function, inflammation, metabolism, and beyond, not one of them addresses or mentions MIR7848. Consequently, the function of MIR7848 is not elucidated in these abstracts; its potential roles, interactions, or regulatory effects remain undetermined and represent an open area for future research.\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "L A Birder, Y Nakamura, S Kiss, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Altered urinary bladder function in mice lacking the vanilloid receptor TRPV1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Neurosci (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nn902"}], "href": "https://doi.org/10.1038/nn902"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12161756"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12161756"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Vijay Lyall, Gerard L Heck, Anna K Vinnikova, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The mammalian amiloride-insensitive non-specific salt taste receptor is a vanilloid receptor-1 variant."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Physiol (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1113/jphysiol.2004.065656"}], "href": "https://doi.org/10.1113/jphysiol.2004.065656"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15146042"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15146042"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Pouya Movahed, Bo A G Jönsson, Bryndis Birnir, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Endogenous unsaturated C18 N-acylethanolamines are vanilloid receptor (TRPV1) agonists."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M507429200"}], "href": "https://doi.org/10.1074/jbc.M507429200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16081411"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16081411"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Julie Keeble, Fiona Russell, Bradley Curtis, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Involvement of transient receptor potential vanilloid 1 in the vascular and hyperalgesic components of joint inflammation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Arthritis Rheum (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/art.21297"}], "href": "https://doi.org/10.1002/art.21297"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16200599"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16200599"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "R Carter W Jones, Linjing Xu, G F Gebhart "}, {"type": "b", "children": [{"type": "t", "text": "The mechanosensitivity of mouse colon afferent fibers and their sensitization by inflammatory mediators require transient receptor potential vanilloid 1 and acid-sensing ion channel 3."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Neurosci (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1523/JNEUROSCI.0703-05.2005"}], "href": "https://doi.org/10.1523/JNEUROSCI.0703-05.2005"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16306411"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16306411"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Lihong Wang, Donna H Wang "}, {"type": "b", "children": [{"type": "t", "text": "TRPV1 gene knockout impairs postischemic recovery in isolated perfused heart in mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Circulation (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1161/CIRCULATIONAHA.105.556274"}], "href": "https://doi.org/10.1161/CIRCULATIONAHA.105.556274"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16314376"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16314376"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Xuming Zhang, Jiehong Huang, Peter A McNaughton "}, {"type": "b", "children": [{"type": "t", "text": "NGF rapidly increases membrane expression of TRPV1 heat-gated ion channels."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "EMBO J (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/sj.emboj.7600893"}], "href": "https://doi.org/10.1038/sj.emboj.7600893"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16319926"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16319926"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Reza Sharif Naeini, Marie-France Witty, Philippe Séguéla, et al. "}, {"type": "b", "children": [{"type": "t", "text": "An N-terminal variant of Trpv1 channel is required for osmosensory transduction."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Neurosci (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nn1614"}], "href": "https://doi.org/10.1038/nn1614"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16327782"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16327782"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "L Cristino, L de Petrocellis, G Pryce, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Immunohistochemical localization of cannabinoid type 1 and vanilloid transient receptor potential vanilloid type 1 receptors in the mouse brain."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neuroscience (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.neuroscience.2006.02.074"}], "href": "https://doi.org/10.1016/j.neuroscience.2006.02.074"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16603318"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16603318"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Silvia Amadesi, Graeme S Cottrell, Lorna Divino, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Protease-activated receptor 2 sensitizes TRPV1 by protein kinase Cepsilon- and A-dependent mechanisms in rats and mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Physiol (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1113/jphysiol.2006.111534"}], "href": "https://doi.org/10.1113/jphysiol.2006.111534"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16793902"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16793902"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Christopher M Elitt, Sabrina L McIlwrath, Jeffery J Lawson, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Artemin overexpression in skin enhances expression of TRPV1 and TRPA1 in cutaneous sensory neurons and leads to behavioral sensitivity to heat and cold."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Neurosci (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1523/JNEUROSCI.2185-06.2006"}], "href": "https://doi.org/10.1523/JNEUROSCI.2185-06.2006"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16914684"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16914684"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Sorana Ciura, Charles W Bourque "}, {"type": "b", "children": [{"type": "t", "text": "Transient receptor potential vanilloid 1 is required for intrinsic osmoreception in organum vasculosum lamina terminalis neurons and for normal thirst responses to systemic hyperosmolality."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Neurosci (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1523/JNEUROSCI.0877-06.2006"}], "href": "https://doi.org/10.1523/JNEUROSCI.0877-06.2006"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16943565"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16943565"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Arpad Szallasi, Francisco Cruz, Pierangelo Geppetti "}, {"type": "b", "children": [{"type": "t", "text": "TRPV1: a therapeutic target for novel analgesic drugs?"}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Trends Mol Med (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.molmed.2006.09.001"}], "href": "https://doi.org/10.1016/j.molmed.2006.09.001"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16996800"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16996800"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Rozita Razavi, Yin Chan, F Nikoo Afifiyan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "TRPV1+ sensory neurons control beta cell stress and islet inflammation in autoimmune diabetes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cell.2006.10.038"}], "href": "https://doi.org/10.1016/j.cell.2006.10.038"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17174891"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17174891"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Rudolph Marsch, Elisabeth Foeller, Gerhard Rammes, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Reduced anxiety, conditioned fear, and hippocampal long-term potentiation in transient receptor potential vanilloid type 1 receptor-deficient mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Neurosci (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1523/JNEUROSCI.3303-06.2007"}], "href": "https://doi.org/10.1523/JNEUROSCI.3303-06.2007"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17251423"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17251423"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Won-Sik Shim, Min-Ho Tak, Mi-Hyun Lee, et al. "}, {"type": "b", "children": [{"type": "t", "text": "TRPV1 mediates histamine-induced itching via the activation of phospholipase A2 and 12-lipoxygenase."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Neurosci (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1523/JNEUROSCI.4643-06.2007"}], "href": "https://doi.org/10.1523/JNEUROSCI.4643-06.2007"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17329430"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17329430"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Li Li Zhang, Dao Yan Liu, Li Qun Ma, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Activation of transient receptor potential vanilloid type-1 channel prevents adipogenesis and obesity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Circ Res (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1161/01.RES.0000262653.84850.8b"}], "href": "https://doi.org/10.1161/01.RES.0000262653.84850.8b"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17347480"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17347480"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Armen N Akopian, Nikita B Ruparel, Nathaniel A Jeske, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Transient receptor potential TRPA1 channel desensitization in sensory neurons is agonist dependent and regulated by TRPV1-directed internalization."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Physiol (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1113/jphysiol.2007.133231"}], "href": "https://doi.org/10.1113/jphysiol.2007.133231"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17584831"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17584831"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Alexandre A Steiner, Victoria F Turek, Maria C Almeida, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Nonthermal activation of transient receptor potential vanilloid-1 channels in abdominal viscera tonically inhibits autonomic cold-defense effectors."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Neurosci (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1523/JNEUROSCI.1483-07.2007"}], "href": "https://doi.org/10.1523/JNEUROSCI.1483-07.2007"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17626206"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17626206"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "D Daly, W Rong, R Chess-Williams, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Bladder afferent sensitivity in wild-type and TRPV1 knockout mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Physiol (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1113/jphysiol.2007.139147"}], "href": "https://doi.org/10.1113/jphysiol.2007.139147"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17627983"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17627983"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "Héctor Salazar, Itzel Llorente, Andrés Jara-Oseguera, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A single N-terminal cysteine in TRPV1 determines activation by pungent compounds from onion and garlic."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Neurosci (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nn2056"}], "href": "https://doi.org/10.1038/nn2056"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18297068"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18297068"}]}, {"type": "r", "ref": 22, "children": [{"type": "t", "text": "Margaux M Salas, Kenneth M Hargreaves, Armen N Akopian "}, {"type": "b", "children": [{"type": "t", "text": "TRPA1-mediated responses in trigeminal sensory neurons: interaction between TRPA1 and TRPV1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur J Neurosci (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/j.1460-9568.2009.06702.x"}], "href": "https://doi.org/10.1111/j.1460-9568.2009.06702.x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19419422"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19419422"}]}, {"type": "r", "ref": 23, "children": [{"type": "t", "text": "Noritaka Imamachi, Goon Ho Park, Hyosang Lee, et al. "}, {"type": "b", "children": [{"type": "t", "text": "TRPV1-expressing primary afferents generate behavioral responses to pruritogens via multiple mechanisms."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.0905605106"}], "href": "https://doi.org/10.1073/pnas.0905605106"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19564617"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19564617"}]}, {"type": "r", "ref": 24, "children": [{"type": "t", "text": "Lauren E Ta, Allan J Bieber, Susan M Carlton, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Transient Receptor Potential Vanilloid 1 is essential for cisplatin-induced heat hyperalgesia in mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Pain (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/1744-8069-6-15"}], "href": "https://doi.org/10.1186/1744-8069-6-15"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20205720"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20205720"}]}, {"type": "r", "ref": 25, "children": [{"type": "t", "text": "Fan Yang, Yuanyuan Cui, KeWei Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Thermosensitive TRP channel pore turret is part of the temperature activation pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.1000357107"}], "href": "https://doi.org/10.1073/pnas.1000357107"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20351268"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20351268"}]}, {"type": "r", "ref": 26, "children": [{"type": "t", "text": "Malin C Lagerström, Katarzyna Rogoz, Bjarke Abrahamsen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "VGLUT2-dependent sensory neurons in the TRPV1 population regulate pain and itch."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neuron (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.neuron.2010.09.016"}], "href": "https://doi.org/10.1016/j.neuron.2010.09.016"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21040852"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21040852"}]}, {"type": "r", "ref": 27, "children": [{"type": "t", "text": "Santosh K Mishra, Sarah M Tisel, Peihan Orestes, et al. "}, {"type": "b", "children": [{"type": "t", "text": "TRPV1-lineage neurons are required for thermal sensation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "EMBO J (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/emboj.2010.325"}], "href": "https://doi.org/10.1038/emboj.2010.325"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21139565"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21139565"}]}, {"type": "r", "ref": 28, "children": [{"type": "t", "text": "Wouter Everaerts, Maarten Gees, Yeranddy A Alpizar, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The capsaicin receptor TRPV1 is a crucial mediator of the noxious effects of mustard oil."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Curr Biol (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cub.2011.01.031"}], "href": "https://doi.org/10.1016/j.cub.2011.01.031"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21315593"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21315593"}]}, {"type": "r", "ref": 29, "children": [{"type": "t", "text": "Elizabeth S Fernandes, Fiona A Russell, Domenico Spina, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A distinct role for transient receptor potential ankyrin 1, in addition to transient receptor potential vanilloid 1, in tumor necrosis factor α-induced inflammatory hyperalgesia and Freund's complete adjuvant-induced monarthritis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Arthritis Rheum (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/art.30150"}], "href": "https://doi.org/10.1002/art.30150"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21360511"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21360511"}]}, {"type": "r", "ref": 30, "children": [{"type": "t", "text": "Y Chen, C Yang, Z J Wang "}, {"type": "b", "children": [{"type": "t", "text": "Proteinase-activated receptor 2 sensitizes transient receptor potential vanilloid 1, transient receptor potential vanilloid 4, and transient receptor potential ankyrin 1 in paclitaxel-induced neuropathic pain."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neuroscience (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.neuroscience.2011.06.085"}], "href": "https://doi.org/10.1016/j.neuroscience.2011.06.085"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21763756"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21763756"}]}, {"type": "r", "ref": 31, "children": [{"type": "t", "text": "Andrés Nieto-Posadas, Giovanni Picazo-Juárez, Itzel Llorente, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Lysophosphatidic acid directly activates TRPV1 through a C-terminal binding site."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Chem Biol (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nchembio.712"}], "href": "https://doi.org/10.1038/nchembio.712"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22101604"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22101604"}]}, {"type": "r", "ref": 32, "children": [{"type": "t", "text": "Zhidan Luo, Liqun Ma, Zhigang Zhao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "TRPV1 activation improves exercise endurance and energy metabolism through PGC-1α upregulation in mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Res (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/cr.2011.205"}], "href": "https://doi.org/10.1038/cr.2011.205"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22184011"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22184011"}]}, {"type": "r", "ref": 33, "children": [{"type": "t", "text": "Kristin Stock, Jitender Kumar, Michael Synowitz, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Neural precursor cells induce cell death of high-grade astrocytomas through stimulation of TRPV1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Med (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nm.2827"}], "href": "https://doi.org/10.1038/nm.2827"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22820645"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22820645"}]}, {"type": "r", "ref": 34, "children": [{"type": "t", "text": "Leah A Pogorzala, Santosh K Mishra, Mark A Hoon "}, {"type": "b", "children": [{"type": "t", "text": "The cellular code for mammalian thermosensation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Neurosci (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1523/JNEUROSCI.5788-12.2013"}], "href": "https://doi.org/10.1523/JNEUROSCI.5788-12.2013"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23536068"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23536068"}]}, {"type": "r", "ref": 35, "children": [{"type": "t", "text": "Mohammad Samie, Xiang Wang, Xiaoli Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A TRP channel in the lysosome regulates large particle phagocytosis via focal exocytosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Dev Cell (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.devcel.2013.08.003"}], "href": "https://doi.org/10.1016/j.devcel.2013.08.003"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23993788"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23993788"}]}, {"type": "r", "ref": 36, "children": [{"type": "t", "text": "Yu Shin Kim, Yuxia Chu, Liang Han, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Central terminal sensitization of TRPV1 by descending serotonergic facilitation modulates chronic pain."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neuron (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.neuron.2013.12.011"}], "href": "https://doi.org/10.1016/j.neuron.2013.12.011"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24462040"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24462040"}]}, {"type": "r", "ref": 37, "children": [{"type": "t", "text": "Céline E Riera, Mark O Huising, Patricia Follett, et al. "}, {"type": "b", "children": [{"type": "t", "text": "TRPV1 pain receptors regulate longevity and metabolism by neuropeptide signaling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cell.2014.03.051"}], "href": "https://doi.org/10.1016/j.cell.2014.03.051"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24855942"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24855942"}]}, {"type": "r", "ref": 38, "children": [{"type": "t", "text": "Samuel Bertin, Yukari Aoki-Nonaka, Petrus Rudolf de Jong, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The ion channel TRPV1 regulates the activation and proinflammatory properties of CD4⁺ T cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Immunol (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ni.3009"}], "href": "https://doi.org/10.1038/ni.3009"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25282159"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25282159"}]}, {"type": "r", "ref": 39, "children": [{"type": "t", "text": "Padmamalini Baskaran, Vivek Krishnan, Jun Ren, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Capsaicin induces browning of white adipose tissue and counters obesity by activating TRPV1 channel-dependent mechanisms."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Br J Pharmacol (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/bph.13514"}], "href": "https://doi.org/10.1111/bph.13514"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27174467"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27174467"}]}, {"type": "r", "ref": 40, "children": [{"type": "t", "text": "Maria Cristina Marrone, Annunziato Morabito, Michela Giustizieri, et al. "}, {"type": "b", "children": [{"type": "t", "text": "TRPV1 channels are critical brain inflammation detectors and neuropathic pain biomarkers in mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ncomms15292"}], "href": "https://doi.org/10.1038/ncomms15292"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28489079"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28489079"}]}, {"type": "r", "ref": 41, "children": [{"type": "t", "text": "Wen Gao, Yuhui Sun, Michelle Cai, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Copper sulfide nanoparticles as a photothermal switch for TRPV1 signaling to attenuate atherosclerosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41467-017-02657-z"}], "href": "https://doi.org/10.1038/s41467-017-02657-z"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29335450"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29335450"}]}, {"type": "r", "ref": 42, "children": [{"type": "t", "text": "Katrin Schnizler, Leonid P Shutov, Michael J Van Kanegan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Protein kinase A anchoring via AKAP150 is essential for TRPV1 modulation by forskolin and prostaglandin E2 in mouse sensory neurons."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Neurosci (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1523/JNEUROSCI.0233-08.2008"}], "href": "https://doi.org/10.1523/JNEUROSCI.0233-08.2008"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18463244"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18463244"}]}, {"type": "r", "ref": 43, "children": [{"type": "t", "text": "Arianne L Motter, Gerard P Ahern "}, {"type": "b", "children": [{"type": "t", "text": "TRPV1-null mice are protected from diet-induced obesity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "FEBS Lett (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.febslet.2008.05.021"}], "href": "https://doi.org/10.1016/j.febslet.2008.05.021"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18503767"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18503767"}]}]}]}