{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRecent investigations into molecular regulation in disease have highlighted diverse regulatory mechanisms involving non‐coding RNAs. In one study examining the proteolytic activity of beta‐site APP cleaving enzyme 1 (BACE1) in the nervous system—which principally focused on identifying and validating novel in vivo substrates of BACE1—complex regulatory pathways were uncovered. Although this work did not explore miR-7855, it contributes to the broader context of protein processing and molecular regulation in neurological tissues."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn a separate study focusing on hepatocellular carcinoma (HCC), the long non‐coding RNA AC006262.5 was found to bind and regulate miR-7855-5p, a miRNA that functions as a tumor suppressor. This regulatory interaction establishes a feedback loop in which AC006262.5 upregulation leads to decreased miR-7855-5p expression, thereby relieving miR-7855-5p-mediated repression of BPY2C. The net result is an enhancement of proliferation, migration, and invasiveness of HCC cells, highlighting miR-7855-5p’s critical role in counteracting tumor progression. These findings suggest that restoring miR-7855-5p function might offer a novel therapeutic avenue in HCC."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Jasenka Rudan Njavro, Jakob Klotz, Bastian Dislich, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Mouse brain proteomics establishes MDGA1 and CACHD1 as in vivo substrates of the Alzheimer protease BACE1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "FASEB J (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1096/fj.201902347R"}], "href": "https://doi.org/10.1096/fj.201902347R"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31908000"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31908000"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Fen-Rong Chen, Yan Wang, Yan Cheng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The AC006262.5-miR-7855-5p-BPY2C axis facilitates hepatocellular carcinoma proliferation and migration."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Cell Biol (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1139/bcb-2019-0239"}], "href": "https://doi.org/10.1139/bcb-2019-0239"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32956593"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32956593"}]}]}]}