{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRecent investigations into microRNA regulation in ovarian follicle development have identified hsa‐miR‐7973 as a post‐transcriptional regulator with a potential role in modulating extracellular matrix composition and cell–cell interactions. In studies using a human granulosa cell line, hsa‐miR‐7973 was ectopically expressed and its effect on gene expression was examined using microarrays, bioinformatic target predictions, and luciferase reporter assays. This analysis confirmed that hsa‐miR‐7973 directly regulates target genes including ADAM19, PXDN, and FMNL3, which are implicated in extracellular matrix remodeling and intercellular signaling. Moreover, the expression patterns of hsa‐miR‐7973 in primary cumulus granulosa cell cultures appeared to parallel those of its host gene in response to FSH stimulation, suggesting that this miRNA may contribute to the fine‐tuning of cell–cell communication during follicular development."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Ilmatar Rooda, Kati Hensen, Birgitta Kaselt, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Target prediction and validation of microRNAs expressed from FSHR and aromatase genes in human ovarian granulosa cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41598-020-59186-x"}], "href": "https://doi.org/10.1038/s41598-020-59186-x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32042028"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32042028"}]}]}]}