MIR802 Gene

HGNC Family Non-coding RNAs
Name microRNA 802
Description microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Summary
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nmiR‑802 is emerging as an important regulator of cell proliferation, survival, and inflammation with highly context‐dependent functions. In cholesteatoma, for example, activation of NF‑κB (via p65 binding to its promoter) upregulates miR‑802, which in turn promotes keratinocyte proliferation and cell cycle progression by directly repressing the tumor suppressor PTEN."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn several epithelial cancers miR‑802 appears to act as a tumor suppressor. In breast cancer cells, enforced miR‑802 expression downregulates FoxM1 protein levels, leading to a significant inhibition of cellular proliferation and tumor growth."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " Similarly, in gastric cancer a long noncoding RNA—IGFL2‑AS1—functions as a molecular sponge for miR‑802, thereby reducing its availability to target ARPP19 and contributing to enhanced tumor progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " In the context of pancreatic cancer, another long noncoding RNA (MIR155HG) sequesters miR‑802, and this negative regulation is associated with increased cell growth and poor prognosis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": " By contrast, in tongue squamous cell carcinoma, the precise function of miR‑802 remains to be elucidated"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": ", and studies in epithelial ovarian cancer have similarly highlighted an unclear role for miR‑802 in disease pathogenesis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its involvement in cancer, miR‑802 contributes to metabolic disease; specifically, in obesity‐related nephropathy elevated renal miR‑802 levels directly target the 3′‑untranslated region of the NF‑κB‐repressing factor (NRF), suppressing its expression. This suppression exacerbates inflammatory responses, leading to structural renal disorders and impaired kidney function."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": " \n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nCollectively, these findings underscore that miR‑802 functions in a context‑dependent manner—exhibiting oncogenic activity in cholesteatoma and deleterious effects in renal inflammation, while predominantly acting as a tumor suppressor in several epithelial cancers. Its regulation through direct targeting of key effectors (e.g., PTEN, FoxM1, ARPP19) or indirectly via sequestration by long noncoding RNAs highlights its potential as both a biomarker and therapeutic target in diverse disease settings.\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Nan Li, Zhao-Bing Qin "}, {"type": "b", "children": [{"type": "t", "text": "Inflammation-induced miR-802 promotes cell proliferation in cholesteatoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biotechnol Lett (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s10529-014-1545-y"}], "href": "https://doi.org/10.1007/s10529-014-1545-y"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24867318"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24867318"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Feng Yuan, Wei Wang "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-802 suppresses breast cancer proliferation through downregulation of FoxM1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Med Rep (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/mmr.2015.3921"}], "href": "https://doi.org/10.3892/mmr.2015.3921"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26080894"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26080894"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Yu Ma, Yi Liu, Yan-Song Pu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LncRNA IGFL2-AS1 functions as a ceRNA in regulating ARPP19 through competitive binding to miR-802 in gastric cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Carcinog (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/mc.23155"}], "href": "https://doi.org/10.1002/mc.23155"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31943339"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31943339"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Yan Qin, Xin Liu, Liang Pan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long noncoding RNA MIR155HG facilitates pancreatic cancer progression through negative regulation of miR-802."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biochem (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcb.29060"}], "href": "https://doi.org/10.1002/jcb.29060"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31161625"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31161625"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Qianwen Zhang, Rui Lv, Wenjia Guo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "microRNA-802 inhibits cell proliferation and induces apoptosis in human cervical cancer by targeting serine/arginine-rich splicing factor 9."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biochem (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcb.28321"}], "href": "https://doi.org/10.1002/jcb.28321"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30565744"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30565744"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Bo Yang, Li Sun, Lei Liang "}, {"type": "b", "children": [{"type": "t", "text": "MiRNA-802 suppresses proliferation and migration of epithelial ovarian cancer cells by targeting YWHAZ."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Ovarian Res (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s13048-019-0576-3"}], "href": "https://doi.org/10.1186/s13048-019-0576-3"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31640760"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31640760"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Da Sun, Jia Chen, Wei Wu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MiR-802 causes nephropathy by suppressing NF-κB-repressing factor in obese mice and human."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Mol Med (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/jcmm.14193"}], "href": "https://doi.org/10.1111/jcmm.14193"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30729676"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30729676"}]}]}]}
Synonyms MIRN802, HSA-MIR-802
NCBI Gene ID 768219
API
Download Associations
Predicted Functions View MIR802's ARCHS4 Predicted Functions.
Co-expressed Genes View MIR802's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View MIR802's ARCHS4 Predicted Functions.

Functional Associations

MIR802 has 305 functional associations with biological entities spanning 5 categories (molecular profile, disease, phenotype or trait, functional term, phrase or reference, cell line, cell type or tissue, gene, protein or microRNA) extracted from 13 datasets.

Click the + buttons to view associations for MIR802 from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
CCLE Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR802 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
ChEA Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR802 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
ChEA Transcription Factor Targets transcription factors binding the promoter of MIR802 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
CTD Gene-Disease Associations diseases associated with MIR802 gene/protein from the curated CTD Gene-Disease Associations dataset.
ENCODE Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR802 gene from the ENCODE Histone Modification Site Profiles dataset.
ENCODE Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR802 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
ENCODE Transcription Factor Targets transcription factors binding the promoter of MIR802 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
GeneRIF Biological Term Annotations biological terms co-occuring with MIR802 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
GeneSigDB Published Gene Signatures PubMedIDs of publications reporting gene signatures containing MIR802 from the GeneSigDB Published Gene Signatures dataset.
JASPAR Predicted Transcription Factor Targets transcription factors regulating expression of MIR802 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR802 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.
MotifMap Predicted Transcription Factor Targets transcription factors regulating expression of MIR802 gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset.
Roadmap Epigenomics Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR802 gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset.