{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRecent studies in myocarditis have uncovered that MIR8055 plays a critical anti‐inflammatory role in the heart. In particular, the circular RNA circACSL1 (hsa_circ_0071542) was found to be significantly upregulated during the acute phase of myocarditis, where it functions as a competing endogenous RNA by sponging MIR8055. This sequestration of MIR8055 leads to the de‐repression and subsequent upregulation of MAPK14, a key mediator in inflammatory signaling, thereby aggravating myocardial inflammation, injury, and apoptosis. Importantly, overexpression of MIR8055 was shown to counteract these pro‐inflammatory effects by attenuating the MAPK14 increase, suggesting that MIR8055 acts as a pivotal negative regulator of inflammatory cascades in cardiomyocytes."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nConversely, in investigations focused on tooth development, the extracellular matrix protein Vwde was identified as essential for proper enamel formation through its regulation of cell proliferation and differentiation in inner enamel epithelial cells. Notably, MIR8055 was not implicated in this study, underscoring a tissue‐specific role for MIR8055 wherein its regulatory impact is prominent in the context of myocardial inflammation but does not extend to the extracellular matrix signaling processes critical for enamel development."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": ""}]}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Li Zhang, Bo Han, Huanlong Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Circular RNA circACSL1 aggravated myocardial inflammation and myocardial injury by sponging miR-8055 and regulating MAPK14 expression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Death Dis (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41419-021-03777-7"}], "href": "https://doi.org/10.1038/s41419-021-03777-7"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33986259"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33986259"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Kokoro Iwata, Keita Kawarabayashi, Keigo Yoshizaki, et al. "}, {"type": "b", "children": [{"type": "t", "text": "von Willebrand factor D and EGF domains regulate ameloblast differentiation and enamel formation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Physiol (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcp.30667"}], "href": "https://doi.org/10.1002/jcp.30667"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34957547"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34957547"}]}]}]}