| HGNC Family | Non-coding RNAs |
| Name | microRNA 8073 |
| Description | microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009] |
| Summary |
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nThis study explored the role of microRNA‐8073 in ovarian cancer by examining its influence on malignant progression. The findings indicate that miR‐8073 may suppress or modulate tumor aggressiveness through the regulation of ZnT1 expression, suggesting that alterations in ZnT1 levels could be integral to the progression of ovarian cancer. In essence, miR‐8073 appears to exert its effects by targeting ZnT1, thereby impacting cellular zinc homeostasis and signaling pathways that are critical for the development and advancement of malignancy."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "L Zhang, Y-H Wang, L Wang "}, {"type": "b", "children": [{"type": "t", "text": "MiRNA-8073 targets ZnT1 to inhibit malignant progression of ovarian cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur Rev Med Pharmacol Sci (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.26355/eurrev_201907_18419"}], "href": "https://doi.org/10.26355/eurrev_201907_18419"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31364107"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31364107"}]}]}]}
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| Synonyms | HSA-MIR-8073 |
| NCBI Gene ID | 102465872 |
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| Predicted Functions |
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| Co-expressed Genes |
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| Expression in Tissues and Cell Lines |
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MIR8073 has 0 functional associations with biological entities spanning 0 categories () extracted from 0 datasets.
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If available, associations are ranked by standardized value
| Dataset | Summary |
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