{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nIn cervical cancer, the circular RNA hsa_circRNA_101996 functions as an oncogenic regulator by sponging miR-8075. Under normal conditions, miR-8075 acts as a tumor suppressor by targeting TPX2, an oncogene that promotes cell proliferation, migration, and invasion. However, when hsa_circRNA_101996 is overexpressed, it sequesters miR-8075, thereby relieving TPX2 from miR-8075–mediated repression and contributing to tumor progression and metastasis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn contrast, an independent study in colon carcinoma focused on mechanisms of immune evasion, demonstrating that tumor cells can resist cytotoxic lymphocyte–mediated killing through the cooperative expression of intracellular serpins (SPI-6 and SPI-CI). While this work highlights another facet of tumor survival, it does not implicate miR-8075 in its reported mechanisms."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Tiefang Song, Aili Xu, Zongfeng Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "CircRNA hsa_circRNA_101996 increases cervical cancer proliferation and invasion through activating TPX2 expression by restraining miR-8075."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Physiol (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcp.28128"}], "href": "https://doi.org/10.1002/jcp.28128"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30633364"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30633364"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Michael Bots, Ingrid G M Kolfschoten, Sandra A Bres, et al. "}, {"type": "b", "children": [{"type": "t", "text": "SPI-CI and SPI-6 cooperate in the protection from effector cell-mediated cytotoxicity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Blood (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1182/blood-2004-03-0791"}], "href": "https://doi.org/10.1182/blood-2004-03-0791"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15454490"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15454490"}]}]}]}