{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nIn osteoarthritis, microRNA‐8082 (miR‐8082) functions as a key regulatory mediator of chondrocyte inflammation. Elevated levels of miR‐8082, as observed in patients with OA, are associated with decreased expression of both the long noncoding RNA NAV2‐AS5 and TNFAIP3 interacting protein 2 (TNIP2). Mechanistic studies in LPS-treated chondrocytes have shown that NAV2‐AS5 acts as a molecular sponge for miR‐8082, thereby limiting miR‐8082’s inhibitory impact on TNIP2. In turn, inhibition of miR‐8082 leads to enhanced cell proliferation, improved cell cycle progression, reduced apoptosis, and modulation of inflammatory cytokine release. Thus, miR‐8082 appears to exacerbate the inflammatory processes in chondrocytes by suppressing TNIP2, while its targeted inhibition, either directly or via NAV2‐AS5 overexpression, alleviates these pathological changes in OA."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Pu Wang, Yuhao Wang, Baoan Ma "}, {"type": "b", "children": [{"type": "t", "text": "Long noncoding RNA "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "NAV2-AS5"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": " relieves chondrocyte inflammation by targeting miR-8082/"}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "TNIP2"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": " in osteoarthritis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Cycle (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/15384101.2022.2154554"}], "href": "https://doi.org/10.1080/15384101.2022.2154554"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36503346"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36503346"}]}]}]}