{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRecent evidence indicates that miR‑8485 can be secreted within exosomes derived from mesenchymal stem cells in the oral cavity, where it promotes tumor cell proliferation, migration, and invasion. These findings suggest that aberrant expression and exosomal delivery of miR‑8485 may contribute to the progression of premalignant lesions toward oral carcinogenesis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn a separate context, chondrocyte‐derived exosomal miR‑8485 has been shown to facilitate the chondrogenic differentiation of bone marrow mesenchymal stem cells. Mechanistically, miR‑8485 targets inhibitors such as GSK3B and DACT1, thereby activating the Wnt/β‑catenin signaling pathway—a process that may hold promise for innovative approaches in cartilage reconstruction."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nMoreover, in the setting of cardiomyocyte injury associated with chronic heart failure, miR‑8485 levels are markedly reduced in patient plasma. Experimental over‑expression of miR‑8485 counteracts H₂O₂‑induced increases in inflammatory cytokines, apoptosis, and impaired cell viability by directly targeting TP53INP1. Thus, miR‑8485 appears to exert a protective role against cardiomyocyte injury, highlighting its potential as a therapeutic target in cardiac dysfunction."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Wenwen Li, Ying Han, Zhongfang Zhao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Oral mucosal mesenchymal stem cell‑derived exosomes: A potential therapeutic target in oral premalignant lesions."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Oncol (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/ijo.2019.4756"}], "href": "https://doi.org/10.3892/ijo.2019.4756"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30896790"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30896790"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Zeng Li, Yingjie Wang, Shuai Xiang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Chondrocytes-derived exosomal miR-8485 regulated the Wnt/β-catenin pathways to promote chondrogenic differentiation of BMSCs."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2019.12.065"}], "href": "https://doi.org/10.1016/j.bbrc.2019.12.065"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31898972"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31898972"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Xiuying Luo, Yanlin Xu, Ze Zhong, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-8485 alleviates the injury of cardiomyocytes through TP53INP1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biochem Mol Toxicol (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jbt.23159"}], "href": "https://doi.org/10.1002/jbt.23159"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35876212"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35876212"}]}]}]}