MIR875 Gene

HGNC Family Non-coding RNAs
Name microRNA 875
Description microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Summary
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nMIR875 plays diverse roles in cancer biology by modulating key oncogenic and tumor‐suppressive pathways. In several malignancies, such as prostate cancer, colorectal carcinoma, hepatocellular carcinoma, gastric cancer, and HPV‐associated cervical cancer, reconstituted or endogenous MIR875 (in its 5p or 3p forms) acts as a tumor suppressor. Its restoration has been shown to enhance radiosensitivity in prostate cancer by targeting epidermal growth factor receptor (EGFR) and counteracting epithelial‐to‐mesenchymal transition and DNA repair processes. In colorectal carcinoma and hepatocellular carcinoma, MIR875 represses cell proliferation, migration, and invasion while inducing apoptosis through downregulation of oncogenic targets such as EGFR and eIF3a. Similarly, in gastric cancer, MIR875 directly targets NOTCH3—thereby inhibiting NOTCH3‐mediated oncogenic signaling—and in HPV‐related cervical cancer models, MIR875 suppresses the viral E6 oncogene, promoting cell cycle arrest and apoptosis."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "5"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn contrast, in non‐small cell lung cancer (NSCLC) MIR875 has been reported to be upregulated and to promote malignant behaviors. Elevated levels of MIR875 in NSCLC cell lines enhance cell proliferation, migration, and invasion by inhibiting the expression of targets such as SATB2, suggesting an oncogenic role. Consistent with this, studies using NSCLC models—including investigations in A549 cells—have further evaluated the effects of MIR875 modulation, and a lncRNA (HCG11) that sponges MIR875 was found to attenuate its activity, ultimately restraining tumorigenic properties. These observations underscore the context‐dependent and tissue‐specific functions of MIR875, making it a potential target for therapeutic interventions in lung cancer."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "6", "end_ref": "9"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Lin Lin, Qingqing Cai, Xiaoyan Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Two less common human microRNAs miR-875 and miR-3144 target a conserved site of E6 oncogene in most high-risk human papillomavirus subtypes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Protein Cell (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s13238-015-0142-8"}], "href": "https://doi.org/10.1007/s13238-015-0142-8"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25913515"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25913515"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Tiening Zhang, Xun Cai, Qi Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Hsa-miR-875-5p exerts tumor suppressor function through down-regulation of EGFR in colorectal carcinoma (CRC)."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncotarget (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/oncotarget.9944"}], "href": "https://doi.org/10.18632/oncotarget.9944"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27302926"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27302926"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Rihan El Bezawy, Denis Cominetti, Nicola Fenderico, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-875-5p counteracts epithelial-to-mesenchymal transition and enhances radiation response in prostate cancer through repression of the EGFR-ZEB1 axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Lett (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.canlet.2017.02.033"}], "href": "https://doi.org/10.1016/j.canlet.2017.02.033"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28274892"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28274892"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Tianxiang Chen, Liankang Sun, Bowen Yao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA‑875‑5p inhibits tumor growth and metastasis of hepatocellular carcinoma by targeting eukaryotic translation initiation factor 3 subunit a."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncol Rep (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/or.2020.7743"}], "href": "https://doi.org/10.3892/or.2020.7743"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33000235"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33000235"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Wei Kang, Jinglin Zhang, Tingting Huang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "NOTCH3, a crucial target of miR-491-5p/miR-875-5p, promotes gastric carcinogenesis by upregulating PHLDB2 expression and activating Akt pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41388-020-01579-3"}], "href": "https://doi.org/10.1038/s41388-020-01579-3"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33452458"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33452458"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Jun Wang, Yadong Lu, Hao Ding, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The miR-875-5p inhibits SATB2 to promote the invasion of lung cancer cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Gene (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.gene.2017.11.066"}], "href": "https://doi.org/10.1016/j.gene.2017.11.066"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29196257"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29196257"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "J-L Tong, L-L Wang, X-F Ling, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MiR-875 can regulate the proliferation and apoptosis of non-small cell lung cancer cells via targeting SOCS2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur Rev Med Pharmacol Sci (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.26355/eurrev_201906_18189"}], "href": "https://doi.org/10.26355/eurrev_201906_18189"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31298374"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31298374"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "S-S Li, H-J Zhu, J-Y Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MiRNA-875-3p alleviates the progression of colorectal cancer via negatively regulating PLK1 level."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur Rev Med Pharmacol Sci (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.26355/eurrev_202002_20163"}], "href": "https://doi.org/10.26355/eurrev_202002_20163"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32096168"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32096168"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Zhou Su, Mi Chen, Ruilin Ding, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long non‑coding RNA HCG11 suppresses the malignant phenotype of non‑small cell lung cancer cells by targeting a miR‑875/SATB2 axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Med Rep (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/mmr.2021.12191"}], "href": "https://doi.org/10.3892/mmr.2021.12191"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34080031"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34080031"}]}]}]}
Synonyms MIRN875, HSA-MIR-875
NCBI Gene ID 100126309
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Download Associations
Predicted Functions View MIR875's ARCHS4 Predicted Functions.
Co-expressed Genes View MIR875's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View MIR875's ARCHS4 Predicted Functions.

Functional Associations

MIR875 has 230 functional associations with biological entities spanning 4 categories (molecular profile, disease, phenotype or trait, cell line, cell type or tissue, gene, protein or microRNA) extracted from 12 datasets.

Click the + buttons to view associations for MIR875 from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
CCLE Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR875 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
ChEA Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR875 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
ChEA Transcription Factor Targets transcription factors binding the promoter of MIR875 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
COSMIC Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR875 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
CTD Gene-Disease Associations diseases associated with MIR875 gene/protein from the curated CTD Gene-Disease Associations dataset.
ENCODE Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR875 gene from the ENCODE Histone Modification Site Profiles dataset.
ENCODE Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR875 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
ENCODE Transcription Factor Targets transcription factors binding the promoter of MIR875 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
GEO Signatures of Differentially Expressed Genes for Gene Perturbations gene perturbations changing expression of MIR875 gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset.
JASPAR Predicted Transcription Factor Targets transcription factors regulating expression of MIR875 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR875 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.
Roadmap Epigenomics Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR875 gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset.