{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nMiR‐877 functions as a critical regulatory molecule in cancer by acting predominantly as a tumor suppressor. In several malignancies, including hepatocellular carcinoma, bladder, cervical, gastric, non‐small cell lung, prostate, esophageal, osteosarcoma, and breast cancers, down‐regulation or sequestration of miR‐877 through ceRNA networks (via circular RNAs, long non‐coding RNAs, and other sponges) results in the de‐repression of key oncogenic targets such as FOXM1, VEGFA, ATXN7L3, FGF2, GGCT, PMEPA1, ACP5, and CCNA2. This loss of miR‐877 control promotes cellular proliferation, migration, invasion, epithelial–mesenchymal transition, and therapy resistance, while genetic studies also implicate promoter variants in miR‐877 with altered cancer risk."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "15"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its role in cancer, miR‐877 also modulates inflammatory and differentiation processes in non‐malignant conditions. In IgA nephropathy, reduced miR‐877 levels are linked to enhanced production of pro‐inflammatory cytokines such as interleukin‑1β in mesangial cells. In acute respiratory distress syndrome and ischemic stroke, miR‐877–mediated targeting of regulators like CDKN1B contributes to dampening inflammatory cascades and promoting endothelial cell function. Moreover, in vascular smooth muscle cells and osteoblasts, miR‐877 influences cell proliferation and differentiation—via interactions with ceRNAs such as HOXA‑AS2 and targets including EIF4G2—thus impacting tissue repair and bone formation."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "16", "end_ref": "20"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nCollectively, these findings indicate that miR‐877 is a pivotal modulator whose loss or sequestration enhances oncogenic signaling and inflammation, while its restoration can inhibit tumor growth, metastasis, and aberrant inflammatory responses. As a central node in diverse ceRNA networks, miR‐877 holds promise both as a noninvasive biomarker for early cancer detection and as a therapeutic target for counteracting malignancy and inflammatory diseases."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}, {"type": "fg_f", "ref": "16"}, {"type": "fg_f", "ref": "3"}, {"type": "fg_f", "ref": "17"}, {"type": "fg_fs", "start_ref": "5", "end_ref": "8"}, {"type": "fg_f", "ref": "18"}, {"type": "fg_f", "ref": "21"}, {"type": "fg_fs", "start_ref": "9", "end_ref": "14"}, {"type": "fg_f", "ref": "19"}, {"type": "fg_f", "ref": "15"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Xinli Huang, Jianjie Qin, Sen Lu "}, {"type": "b", "children": [{"type": "t", "text": "Up-regulation of miR-877 induced by paclitaxel inhibits hepatocellular carcinoma cell proliferation though targeting FOXM1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Clin Exp Pathol (2015)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25973036"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25973036"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Shiqi Li, Yi Zhu, Zhen Liang, et al. 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