MIR887 Gene

HGNC Family Non-coding RNAs
Name microRNA 887
Description microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Summary
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nMiR‐887 has emerged as a multifunctional microRNA with diverse roles in cancer biology and inflammatory responses. In prostate cancer, for instance, miR‐887 (along with miR‐191-5p) specifically binds to the C-allele of a single nucleotide polymorphism in the 3′-UTR of the oncogene MDM4, thereby inhibiting its translation and reducing cell viability."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In breast cancer, high endogenous levels of miR‐887 in less aggressive, pre–epithelial-to-mesenchymal transition (EMT) cells help suppress phospholipase D activity via downregulation of PLD2 translation, highlighting a tumor–suppressor–like role."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its regulatory functions in oncogenesis, miR‐887 also holds diagnostic and functional significance in other clinical settings. Its isoform miR‐887-5p is being explored as a potential biomarker for endometrial cancer"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": ", while elevated circulating miR‐887-3p levels have been associated with sepsis-induced acute respiratory distress syndrome (ARDS), where it modulates endothelial gene expression, promotes chemokine secretion, and facilitates leukocyte migration."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": " Additionally, systematic analyses in the NCI-60 cancer cell panel reveal that miR‐887 is highly expressed in breast cancer cells and correlates inversely with the efficacy of certain anti-cancer drugs, suggesting a role in drug resistance"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": ", a notion further supported by evidence of extracellular vesicle-mediated miR‐887-3p contributing to chemoresistance in breast cancer."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nFurthermore, emerging data indicate that miR‐887 can act as an oncogenic driver in hepatocellular carcinoma, with its tumor-promoting effects noted across several cancer types."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": " Overall, these findings underscore the context-dependent roles of miR‐887 in regulating gene translation, modulating inflammatory pathways, influencing chemotherapeutic response, and driving tumorigenesis, marking it as a potential target for therapeutic intervention.\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Shane Stegeman, Leire Moya, Luke A Selth, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A genetic variant of MDM4 influences regulation by multiple microRNAs in prostate cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Endocr Relat Cancer (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1530/ERC-15-0013"}], "href": "https://doi.org/10.1530/ERC-15-0013"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25670033"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25670033"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Kristen Fite, Julian Gomez-Cambronero "}, {"type": "b", "children": [{"type": "t", "text": "Down-regulation of MicroRNAs (MiRs) 203, 887, 3619 and 182 Prevents Vimentin-triggered, Phospholipase D (PLD)-mediated Cancer Cell Invasion."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M115.686006"}], "href": "https://doi.org/10.1074/jbc.M115.686006"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26567912"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26567912"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Yan Jiang, Ning Wang, Duo Yin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Changes in the Expression of Serum MiR-887-5p in Patients With Endometrial Cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Gynecol Cancer (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1097/IGC.0000000000000730"}], "href": "https://doi.org/10.1097/IGC.0000000000000730"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27177284"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27177284"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Andrew J Goodwin, Pengfei Li, Perry V Halushka, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Circulating miRNA 887 is differentially expressed in ARDS and modulates endothelial function."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Physiol Lung Cell Mol Physiol (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1152/ajplung.00494.2019"}], "href": "https://doi.org/10.1152/ajplung.00494.2019"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32321279"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32321279"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Zhiyuan Lv, Shuo Wang, Wandong Zhao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA analysis of NCI-60 human cancer cells indicates that miR-720 and miR-887 are potential therapeutic biomarkers for breast cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Drug Discov Ther (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.5582/ddt.2020.03058"}], "href": "https://doi.org/10.5582/ddt.2020.03058"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32863323"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32863323"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Bing Wang, Yueping Wang, Xuedong Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Extracellular Vesicles Carrying miR-887-3p Promote Breast Cancer Cell Drug Resistance by Targeting BTBD7 and Activating the Notch1/Hes1 Signaling Pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Dis Markers (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1155/2022/5762686"}], "href": "https://doi.org/10.1155/2022/5762686"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35655918"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35655918"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Wei Zou, Jun Cheng "}, {"type": "b", "children": [{"type": "t", "text": "MiR-887 Promotes the Progression of Hepatocellular Carcinoma via Targeting VHL."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Technol Cancer Res Treat (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1177/1533033820940425"}], "href": "https://doi.org/10.1177/1533033820940425"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32912113"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32912113"}]}]}]}
Synonyms HSA-MIR-887, MIRN887
NCBI Gene ID 100126347
API
Download Associations
Predicted Functions View MIR887's ARCHS4 Predicted Functions.
Co-expressed Genes View MIR887's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View MIR887's ARCHS4 Predicted Functions.

Functional Associations

MIR887 has 109 functional associations with biological entities spanning 3 categories (functional term, phrase or reference, cell line, cell type or tissue, gene, protein or microRNA) extracted from 3 datasets.

Click the + buttons to view associations for MIR887 from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
GeneSigDB Published Gene Signatures PubMedIDs of publications reporting gene signatures containing MIR887 from the GeneSigDB Published Gene Signatures dataset.
GEO Signatures of Differentially Expressed Genes for Gene Perturbations gene perturbations changing expression of MIR887 gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR887 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.