{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nmiR-888 has emerged as an oncogenic microRNA with a significant role in prostate cancer progression. Expression profiling in syngeneic human prostate cancer cell lines revealed that miR-888 is markedly overexpressed in highly metastatic PC3-ML cells compared to non‑invasive counterparts, and its elevated levels are also described in primary prostate tumors—especially in those exhibiting seminal vesicle invasion—as well as in expressed prostatic secretions from patients with high‑grade disease. This pattern of overexpression indicates that miR-888 may serve as a potential diagnostic biomarker for aggressive prostate cancer."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}, {"type": "p", "children": [{"type": "t", "text": "\nFunctional studies demonstrate that the overexpression of miR-888 enhances key oncogenic properties in vitro by increasing cell proliferation, migration, and colony formation in prostate cancer cell lines, whereas its inhibition significantly impedes these processes. Mechanistically, miR-888 contributes to cancer progression by downregulating tumor suppressor genes such as RBL1 and SMAD4, thereby promoting pathways that favor malignant transformation and metastasis. These findings underscore the potential of miR-888 not only as a biomarker but also as a therapeutic target in aggressive prostate cancer"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}]}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Holly Lewis, Raymond Lance, Dean Troyer, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-888 is an expressed prostatic secretions-derived microRNA that promotes prostate cell growth and migration."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Cycle (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4161/cc.26984"}], "href": "https://doi.org/10.4161/cc.26984"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24200968"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24200968"}]}]}]}