{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRecent research has identified microRNA-891b (miR-891b) as a pivotal regulator in pancreatic ductal adenocarcinoma (PDAC). In this context, miR-891b functions as a tumor suppressor by directly targeting the Cbl‐b gene, which in turn leads to an upregulation of the tumor suppressor protein p21, ultimately inhibiting PDAC cell proliferation. Moreover, its expression levels have been closely linked with patient prognosis, establishing miR-891b as an independent predictor of overall survival in PDAC cases."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "In viral infections such as those caused by Enterovirus 71 (EV71), miR-891b participates in a regulatory axis that modulates apoptosis. Here, the long noncoding RNA lnc-IRAK3-3 is down-regulated during EV71 infection, and its ability to sequester miR-891b is diminished. The resulting increase in free miR-891b leads to the suppression of GADD45β expression, a change that contributes to the regulation of caspase3 and PARP cleavage, thereby influencing the apoptotic process and protecting host cells from excessive damage."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "Additionally, miR-891b has been implicated in breast cancer, where it appears to sensitize cancer cells to alkylating chemotherapeutic drugs through mechanisms involving poly(ADP-ribose) polymerases (PARPs). This suggests that miR-891b plays a broader role in modulating cellular responses to DNA damage and chemotherapy across different cancer types."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Qian Dong, Ce Li, Xiaofang Che, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-891b is an independent prognostic factor of pancreatic cancer by targeting Cbl-b to suppress the growth of pancreatic cancer cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncotarget (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/oncotarget.11001"}], "href": "https://doi.org/10.18632/oncotarget.11001"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27494897"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27494897"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Yu-Wen Liao, Bing-Ching Ho, Min-Hsuan Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Host relieves lnc-IRAK3-3-sequestered miR-891b to attenuate apoptosis in Enterovirus 71 infection."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Microbiol (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/cmi.13043"}], "href": "https://doi.org/10.1111/cmi.13043"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31099182"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31099182"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Shujian Xu, Cui Zhao, Zhongming Jia, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Down-regulation of PARP1 by miR-891b sensitizes human breast cancer cells to alkylating chemotherapeutic drugs."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Arch Gynecol Obstet (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00404-017-4444-3"}], "href": "https://doi.org/10.1007/s00404-017-4444-3"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28660502"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28660502"}]}]}]}