{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRecent studies in pancreatic ductal adenocarcinoma (PDAC) have shown that an oncogenic circular RNA, circ_0007534, promotes tumorigenesis in part by sponging microRNAs such as miR‑892b. This interaction diminishes the availability of miR‑892b to regulate its target genes, thereby contributing to enhanced proliferation, migration, invasion, and decreased apoptosis in PDAC cells."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn the setting of metabolic disorders, circulating levels of miR‑892b have been found to be significantly elevated in patients with type 2 diabetes mellitus and even more so in those with microvascular complications. This upregulation suggests that miR‑892b may serve as an auxiliary biomarker and potential risk factor for diabetic-associated vascular pathology."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn breast cancer, miR‑892b acts as a tumor suppressor whose expression is notably downregulated in tumor tissues, a reduction that correlates with poor patient outcomes. Experimental overexpression of miR‑892b suppresses tumor growth, metastasis, and angiogenesis by directly targeting several key mediators of the NF‑κB signaling cascade—including TRAF2, TAK1, and TAB3—thus mitigating the sustained activation of this pro‐tumorigenic pathway."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nSimilarly, functional investigations in bladder cancer have demonstrated that miR‑892b inhibits cell proliferation, migration, and invasion. Its overexpression induces G1 phase cell cycle arrest and modulates critical pathways via downregulation of cyclin D1 and CDK6, accompanied by upregulation of p19ARF, as well as suppression of MMP‑9 expression through effects on Sp‑1 transcription factor activity. These findings highlight miR‑892b’s therapeutic potential as an inhibitor of tumor progression in advanced bladder cancers."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Liguo Hao, Wei Rong, Lianjie Bai, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Upregulated circular RNA circ_0007534 indicates an unfavorable prognosis in pancreatic ductal adenocarcinoma and regulates cell proliferation, apoptosis, and invasion by sponging miR-625 and miR-892b."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biochem (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcb.27658"}], "href": "https://doi.org/10.1002/jcb.27658"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30382592"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30382592"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Cheng Wang, Shujun Wan, Ting Yang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Increased serum microRNAs are closely associated with the presence of microvascular complications in type 2 diabetes mellitus."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/srep20032"}], "href": "https://doi.org/10.1038/srep20032"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26831044"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26831044"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Lili Jiang, Liang Yu, Xin Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-892b Silencing Activates NF-κB and Promotes Aggressiveness in Breast Cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Res (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/0008-5472.CAN-15-1770"}], "href": "https://doi.org/10.1158/0008-5472.CAN-15-1770"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26747895"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26747895"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Seung-Shick Shin, Sung-Soo Park, Byungdoo Hwang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-892b influences proliferation, migration and invasion of bladder cancer cells by mediating the p19ARF/cyclin D1/CDK6 and Sp-1/MMP-9 pathways."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncol Rep (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/or.2016.5052"}], "href": "https://doi.org/10.3892/or.2016.5052"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27573859"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27573859"}]}]}]}