{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nMIR9-3HG appears to function as an upstream regulator in breast cancer by governing the expression of miR-9—a key microRNA that targets the transcription factor FOXO1. The study demonstrates that miR-9, likely processed from MIR9-3HG, suppresses FOXO1 expression, thereby relieving FOXO1’s inhibitory effects on cellular proliferation, migration, and invasion. As a result, the MIR9-3HG/miR-9/FOXO1 axis contributes to the aggressive behavior of breast cancer cells, suggesting that MIR9-3HG may serve as both a biomarker and potential therapeutic target for mitigating tumor progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "D-Z Liu, B Chang, X-D Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-9 promotes the proliferation, migration, and invasion of breast cancer cells via down-regulating FOXO1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin Transl Oncol (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s12094-017-1650-1"}], "href": "https://doi.org/10.1007/s12094-017-1650-1"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28397066"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28397066"}]}]}]}