MIR920 Gene

HGNC Family Non-coding RNAs
Name microRNA 920
Description microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Summary
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nMicroRNA‑920 (miR‑920) has emerged as a multifunctional post‐transcriptional regulator in several disease contexts. In hepatocellular carcinoma, a 9 bp insertion/deletion polymorphism in the 3′ untranslated region of beta‑TrCP disrupts a binding site for miR‑920, suggesting that, under normal circumstances, miR‑920 represses beta‑TrCP expression and thereby modulates oncogenic NFκB signaling pathways."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "Sensitive plasma assays have also prompted investigation of miR‑920 as a potential biomarker for liver cirrhosis, indicating its value in noninvasive diagnostic strategies for chronic liver disease."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "Moreover, functional studies are currently exploring the role of miR‑920 in the osteogenic differentiation of human bone mesenchymal stem cells, which may reveal important regulatory mechanisms involved in bone formation and repair."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "In the context of glioblastoma, miR‑920 acts as an upstream regulator of lymphocyte‑specific protein 1 (LSP1). By negatively modulating LSP1 expression, miR‑920 appears to dampen malignant cell behaviors, likely through attenuation of key kinases in the JAK2/STAT5 signaling cascade."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Shougong Chen, Yan He, Jun Ding, et al. "}, {"type": "b", "children": [{"type": "t", "text": "An insertion/deletion polymorphism in the 3' untranslated region of beta-transducin repeat-containing protein (betaTrCP) is associated with susceptibility for hepatocellular carcinoma in Chinese."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2009.11.096"}], "href": "https://doi.org/10.1016/j.bbrc.2009.11.096"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19931512"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19931512"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Mohabbat Ghaempoor, Ehsan Arefian, Seyed R Mohebbi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Circulating miR-625 as an Emerging Biomarker for Liver Cirrhosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin Lab (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.7754/Clin.Lab.2018.180704"}], "href": "https://doi.org/10.7754/Clin.Lab.2018.180704"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30969085"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30969085"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Jun-Pu Zha, Xiao-Qing Wang, Jun Di "}, {"type": "b", "children": [{"type": "t", "text": "MiR-920 promotes osteogenic differentiation of human bone mesenchymal stem cells by targeting HOXA7."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Orthop Surg Res (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s13018-020-01775-7"}], "href": "https://doi.org/10.1186/s13018-020-01775-7"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32650806"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32650806"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Ping Cong, Hua-Ying Hou, Wei Wei, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MiR-920 and LSP1 co-regulate the growth and migration of glioblastoma cells by modulation of JAK2/STAT5 pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Bioenerg Biomembr (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s10863-020-09848-2"}], "href": "https://doi.org/10.1007/s10863-020-09848-2"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32770294"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32770294"}]}]}]}
Synonyms HSA-MIR-920, MIRN920
NCBI Gene ID 100126320
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Predicted Functions View MIR920's ARCHS4 Predicted Functions.
Co-expressed Genes View MIR920's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View MIR920's ARCHS4 Predicted Functions.

Functional Associations

MIR920 has 255 functional associations with biological entities spanning 5 categories (molecular profile, disease, phenotype or trait, functional term, phrase or reference, cell line, cell type or tissue, gene, protein or microRNA) extracted from 15 datasets.

Click the + buttons to view associations for MIR920 from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
CCLE Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR920 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
ChEA Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR920 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
ChEA Transcription Factor Targets transcription factors binding the promoter of MIR920 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
COSMIC Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR920 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
ENCODE Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR920 gene from the ENCODE Histone Modification Site Profiles dataset.
ENCODE Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR920 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
ENCODE Transcription Factor Targets transcription factors binding the promoter of MIR920 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
GAD Gene-Disease Associations diseases associated with MIR920 gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.
GeneRIF Biological Term Annotations biological terms co-occuring with MIR920 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
GeneSigDB Published Gene Signatures PubMedIDs of publications reporting gene signatures containing MIR920 from the GeneSigDB Published Gene Signatures dataset.
HuGE Navigator Gene-Phenotype Associations phenotypes associated with MIR920 gene by text-mining GWAS publications from the HuGE Navigator Gene-Phenotype Associations dataset.
JASPAR Predicted Transcription Factor Targets transcription factors regulating expression of MIR920 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR920 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.
MotifMap Predicted Transcription Factor Targets transcription factors regulating expression of MIR920 gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset.
Roadmap Epigenomics Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR920 gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset.