{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nThe dysregulation of noncoding RNAs is emerging as a key contributor to cancer progression. In HBV-related hepatocellular carcinoma, the long noncoding RNA n335586 is significantly upregulated and promotes cell migration, invasion, and epithelial–mesenchymal transition. Mechanistically, n335586 acts as a competing endogenous RNA by binding to miR-924, thereby relieving the repression on its host gene CKMT1A; this axis results in enhanced metastatic potential of HCC cells. Thus, miR-924 normally functions as a negative regulator of CKMT1A, and its sequestration by n335586 contributes to cancer progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn a related exploration of noncoding RNA biology in cancer, another study focuses on the regulatory roles of circular RNAs in non–small cell lung cancer. Although this study does not specifically address miR-924, it reinforces the broader importance of noncoding RNA networks as critical modulators of tumorigenesis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Hongxia Fan, Ping Lv, Ting Mu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LncRNA n335586/miR-924/CKMT1A axis contributes to cell migration and invasion in hepatocellular carcinoma cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Lett (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.canlet.2018.05.010"}], "href": "https://doi.org/10.1016/j.canlet.2018.05.010"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29753758"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29753758"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Yunzhong Liu, Shujun Wang, Songli Pan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Circ_0000463 contributes to the progression and glutamine metabolism of non-small-cell lung cancer by targeting miR-924/SLC1A5 signaling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Lab Anal (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcla.24116"}], "href": "https://doi.org/10.1002/jcla.24116"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34811815"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34811815"}]}]}]}