{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRecent studies have identified miR-934 as an oncogenic microRNA that drives tumor progression by fine‐tuning key regulatory pathways in different cancer types. In bladder cancer, miR-934 is highly overexpressed and functions to promote cell proliferation by directly binding to the 3′-UTR of ubiquitin‐conjugating enzyme 2N (UBE2N) mRNA. This binding down-regulates UBE2N protein levels, which in turn attenuates the degradation of CDK6, leading to CDK6 protein accumulation and enhanced tumor cell growth."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nSimilarly, miR-934 plays a crucial role in colorectal and triple-negative breast cancers. In colorectal cancer cells, elevated miR-934 levels promote proliferation, migration, invasion, and angiogenesis by directly targeting the tumor suppressor BTG2, resulting in its reduced expression and thereby facilitating oncogenic behavior. In triple-negative breast cancer, miR-934 is specifically associated with the modulation of epithelial–mesenchymal transition programs by regulating a set of mesenchymal genes, and its inhibition leads to a marked decrease in the migratory capabilities of these cancer cells. Together, these findings underscore the importance of miR-934 as a potent oncomiR that orchestrates tumorigenic processes through distinct molecular effectors in multiple cancer contexts."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Huiying Yan, Shuwei Ren, Qi Lin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Inhibition of UBE2N-dependent CDK6 protein degradation by miR-934 promotes human bladder cancer cell growth."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "FASEB J (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1096/fj.201900499RR"}], "href": "https://doi.org/10.1096/fj.201900499RR"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31373842"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31373842"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Bo Li, Xianyi Liu, Guogang Wu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-934 facilitates cell proliferation, migration, invasion and angiogenesis in colorectal cancer by targeting B-cell translocation gene 2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Bioengineered (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/21655979.2021.1996505"}], "href": "https://doi.org/10.1080/21655979.2021.1996505"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34699325"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34699325"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Jorge Alberto Contreras-Rodríguez, Jonathan Puente-Rivera, Diana Margarita Córdova-Esparza, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Bioinformatic miRNA-mRNAs Analysis Revels to miR-934 as a Potential Regulator of the Epithelial-Mesenchymal Transition in Triple-Negative Breast Cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cells (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/cells12060834"}], "href": "https://doi.org/10.3390/cells12060834"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36980175"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36980175"}]}]}]}