MIR935 Gene

HGNC Family Non-coding RNAs
Name microRNA 935
Description microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Summary
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nMicroRNA‐935 has emerged as a key regulator in various malignancies. In hepatocellular carcinoma, miR‐935 is upregulated and promotes cell proliferation, tumorigenesis, and cell cycle progression by directly repressing SOX7, which in turn leads to increased levels of the G1/S phase regulators cyclin D1 and c‐Myc."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " Similarly, in conventional gastric cancer and colorectal cancer, elevated miR‐935 expression correlates with enhanced cellular proliferation, migration, invasion, and tumor progression, where it exerts its oncogenic role by targeting tumor suppressors such as SOX7 and INPP4A."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " In non‐small cell lung cancer, a potential role for miR‑935 has been hypothesized in carcinogenesis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn contrast, in gastric signet ring cell carcinoma, miR‑935 expression is reduced, and its overexpression suppresses cell proliferation, migration, and invasion by directly targeting Notch1, suggesting a tumor‐suppressive function in this subtype."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": " Moreover, differential expression analysis of miR‑935 in cortical brain tissues and plasma samples of refractory temporal lobe epilepsy patients points to its potential utility as a diagnostic biomarker."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nAdding further complexity to its biological roles, miR‑935 has been implicated in modulating the tumor microenvironment. Studies have revealed that in the context of intermediate-sized hyaluronan (HA) fragment stimulation, miR‑935 is involved in driving the polarization of macrophages toward an M2-like, tumor-associated phenotype, likely through regulation of factors such as C/EBPβ."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": " Collectively, these findings underscore the multifaceted functions of miR‑935, which can act either as an oncogene or a tumor suppressor in a context-dependent manner, while also offering promise as a biomarker and potential therapeutic target in diverse diseases.\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Xiaorui Liu, Jingjing Li, Zujiang Yu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-935 Promotes Liver Cancer Cell Proliferation and Migration by Targeting SOX7."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncol Res (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3727/096504016X14747300207374"}], "href": "https://doi.org/10.3727/096504016X14747300207374"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27697092"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27697092"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Meng Yang, Guozhong Cui, Mingjian Ding, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-935 promotes gastric cancer cell proliferation by targeting SOX7."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biomed Pharmacother (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.biopha.2016.01.011"}], "href": "https://doi.org/10.1016/j.biopha.2016.01.011"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27044823"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27044823"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Ying Huang, Wenfeng Xiao, Xiuli Jiang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-935 acts as a prognostic marker and promotes cell proliferation, migration, and invasion in colorectal cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Biomark (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3233/CBM-190183"}], "href": "https://doi.org/10.3233/CBM-190183"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31524145"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31524145"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "C Wang, S Li, J Xu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "microRNA-935 is reduced in non-small cell lung cancer tissue, is linked to poor outcome, and acts on signal transduction mediator E2F7 and the AKT pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Br J Biomed Sci (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/09674845.2018.1520066"}], "href": "https://doi.org/10.1080/09674845.2018.1520066"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30203720"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30203720"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Chao Yan, Jianchun Yu, Weiming Kang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-935 suppresses gastric signet ring cell carcinoma tumorigenesis by targeting Notch1 expression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2015.12.116"}], "href": "https://doi.org/10.1016/j.bbrc.2015.12.116"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26742429"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26742429"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Yuqiang Sun, Xiaofeng Wang, Zeyang Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Expression of microRNA-129-2-3p and microRNA-935 in plasma and brain tissue of human refractory epilepsy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Epilepsy Res (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.eplepsyres.2016.09.016"}], "href": "https://doi.org/10.1016/j.eplepsyres.2016.09.016"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27689807"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27689807"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Boke Zhang, Yan Du, Yiqing He, et al. "}, {"type": "b", "children": [{"type": "t", "text": "INT-HA induces M2-like macrophage differentiation of human monocytes via TLR4-miR-935 pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Immunol Immunother (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00262-018-2261-6"}], "href": "https://doi.org/10.1007/s00262-018-2261-6"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30341559"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30341559"}]}]}]}
Synonyms MIR-935, HSA-MIR-935, MIRN935
NCBI Gene ID 100126325
API
Download Associations
Predicted Functions View MIR935's ARCHS4 Predicted Functions.
Co-expressed Genes View MIR935's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View MIR935's ARCHS4 Predicted Functions.

Functional Associations

MIR935 has 591 functional associations with biological entities spanning 3 categories (molecular profile, cell line, cell type or tissue, gene, protein or microRNA) extracted from 10 datasets.

Click the + buttons to view associations for MIR935 from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
CCLE Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR935 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
ChEA Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR935 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
ChEA Transcription Factor Targets transcription factors binding the promoter of MIR935 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
COSMIC Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR935 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
ENCODE Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR935 gene from the ENCODE Histone Modification Site Profiles dataset.
ENCODE Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR935 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
ENCODE Transcription Factor Targets transcription factors binding the promoter of MIR935 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR935 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.
MotifMap Predicted Transcription Factor Targets transcription factors regulating expression of MIR935 gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset.
Roadmap Epigenomics Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR935 gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset.