{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRecent studies have elucidated the tumor‐suppressive role of miR-936 in several cancer types. In glioma, for instance, miR-936 is directly inhibited by the overexpressed circular RNA circ_0001162, leading to the derepression of its target ERBB4 and promoting cell proliferation, migration, and invasion. Similarly, in gastric cancer, miR-936 down-regulates FGF2 expression and modulates the PI3K/Akt signaling pathway to impede tumor progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n \nDisruptions in miR-936 function have also been implicated in other malignancies. In non-small cell lung cancer, miR-936 targets G protein-coupled receptor 78 (GPR78) to regulate chemoresistance through the Galphaq Rho GTPase pathway. In hepatocellular carcinoma, miR-936 is markedly reduced; its overexpression suppresses cell proliferation and migration, induces G1 cell cycle arrest, and achieves these effects in part through the direct downregulation of jagged-1 (JAG1). Collectively, these findings highlight miR-936 as a potent tumor suppressor, where its loss or inhibition contributes to disease progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n \nAlthough circular RNAs have been studied in the context of environmental factors such as PM2.5—with implications for respiratory illnesses—the direct involvement of miR-936 in pollutant-related pathophysiological responses has not yet been established, underscoring potential directions for future research."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Dexiang Zhou, Xiaofeng Lin, Peng Wang, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-936 promotes proliferation and invasion of gastric cancer cells by down-regulating FGF2 expression and activating P13K/Akt signaling pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur Rev Med Pharmacol Sci (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.26355/eurrev_202006_21658"}], "href": "https://doi.org/10.26355/eurrev_202006_21658"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32633361"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32633361"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Xiuming Huang, Yanyan Wang, Minbiao Chen, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Mechanism through which the hsa-circ_0000992- hsa- miR- 936-AKT3 regulatory network promotes the PM"}, {"type": "a", "children": [{"type": "t", "text": "sub"}], "href": "sub"}, {"type": "t", "text": "2.5"}, {"type": "a", "children": [{"type": "t", "text": "/sub"}], "href": "/sub"}, {"type": "t", "text": "-induced inflammatory response in human bronchial epithelial cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Ecotoxicol Environ Saf (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ecoenv.2023.115778"}], "href": "https://doi.org/10.1016/j.ecoenv.2023.115778"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38147774"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38147774"}]}]}]}