{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nMIR941-1 has been identified as a microRNA exhibiting tumor suppressor properties in the context of gastric cancer. In several gastric cancer cell lines and primary tumors, MIR941-1 is transcriptionally silenced via DNA hypermethylation, and its restoration in cancer cells leads to the inhibition of proliferation and migration by downregulating key oncogenic targets. These findings highlight its role as a critical regulator of cell growth and invasion in malignant tissues."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n \n \nIn addition to its function in tumor suppression, the general role of circulating microRNAs as biomarkers has been under investigation. Studies suggest that miRNAs may serve as diagnostic and prognostic indicators in cardiovascular diseases, such as acute coronary syndromes. Although MIR941-1’s direct involvement in these contexts has yet to be fully elucidated, its potential as a circulating biomarker remains an intriguing possibility."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n \n \nEmerging evidence also supports a broader role for RNA molecules, including microRNAs like MIR941-1, in transgenerational inheritance and intercellular communication. The mobility and genomic impact of RNAs provide a plausible mechanism for the somatic transmission of acquired traits, suggesting that MIR941-1 might participate in epigenetic processes beyond its tumor suppressor function."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n \n \nFinally, while investigating protective cellular mechanisms, studies involving exosomes derived from bone marrow stromal cells have demonstrated protective effects on target cells such as human endometrial stromal cells. These findings reinforce the concept that miRNAs, potentially including MIR941-1, could be instrumental in orchestrating intercellular protective signals and tissue repair, although further research is required to define its specific role in these contexts."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Joong-Gook Kim, Tae-Oh Kim, Jin-Han Bae, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Epigenetically regulated MIR941 and MIR1247 target gastric cancer cell growth and migration."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Epigenetics (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4161/epi.29007"}], "href": "https://doi.org/10.4161/epi.29007"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24785261"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24785261"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Ruina Bai, Qiaoning Yang, Ruixi Xi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-941 as a promising biomarker for acute coronary syndrome."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "BMC Cardiovasc Disord (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12872-017-0653-8"}], "href": "https://doi.org/10.1186/s12872-017-0653-8"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28830367"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28830367"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Elizabeth A O'Brien, Kathleen S Ensbey, Bryan W Day, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Direct evidence for transport of RNA from the mouse brain to the germline and offspring."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "BMC Biol (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12915-020-00780-w"}], "href": "https://doi.org/10.1186/s12915-020-00780-w"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32354330"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32354330"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Yu Wang, Xiaofei Sun, Qing Yang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Exosomes from bone mesenchymal stem cells alleviate mifepristone-induced human endometrial stromal cell injury by inhibiting TLR3 via delivering miR-941."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Physiol Int (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1556/2060.2022.00108"}], "href": "https://doi.org/10.1556/2060.2022.00108"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36422693"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36422693"}]}]}]}