MIR941-2 Gene

HGNC Family Non-coding RNAs
Name microRNA 941-2
Description microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Summary
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High expression in hepatocytes is observed under normal conditions, but a marked downregulation occurs in steatotic livers, suggesting an involvement in nonalcoholic fatty liver disease pathogenesis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": " Moreover, overexpression of IRF2BP2 in cardiomyocytes protects against sepsis‐induced myocardial dysfunction by activating AMPK signaling, thereby reducing inflammation and cell death."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": " Finally, IRF2BP2 is essential for fetal hepatic erythropoiesis, with its deficiency leading to upregulation of interferon‐responsive genes and hematopoietic transcription factors—a dysregulation that appears to predispose to lymphoma development in adulthood."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Allen C T Teng, Drew Kuraitis, Shelley A Deeke, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "IRF2BP2 transcriptional repressor restrains naive CD4 T cell activation and clonal expansion induced by TCR triggering."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Leukoc Biol (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1189/jlb.2A0815-368R"}], "href": "https://doi.org/10.1189/jlb.2A0815-368R"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27286791"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27286791"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Jing Fang, Tianyu Li, Xuehai Zhu, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Hepatic IRF2BP2 Mitigates Nonalcoholic Fatty Liver Disease by Directly Repressing the Transcription of ATF3."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hepatology (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/hep.30950"}], "href": "https://doi.org/10.1002/hep.30950"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31529495"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31529495"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Tianyu Li, Qiang Luo, Li He, et al. 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Synonyms MIRN941-2
NCBI Gene ID 100126339
API
Download Associations
Predicted Functions View MIR941-2's ARCHS4 Predicted Functions.
Co-expressed Genes View MIR941-2's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View MIR941-2's ARCHS4 Predicted Functions.

Functional Associations

MIR941-2 has 261 functional associations with biological entities spanning 3 categories (molecular profile, cell line, cell type or tissue, gene, protein or microRNA) extracted from 8 datasets.

Click the + buttons to view associations for MIR941-2 from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
CCLE Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR941-2 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
ENCODE Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR941-2 gene from the ENCODE Histone Modification Site Profiles dataset.
ENCODE Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR941-2 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
ENCODE Transcription Factor Targets transcription factors binding the promoter of MIR941-2 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
GTEx Tissue Gene Expression Profiles tissues with high or low expression of MIR941-2 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles dataset.
JASPAR Predicted Transcription Factor Targets transcription factors regulating expression of MIR941-2 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR941-2 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.
Roadmap Epigenomics Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR941-2 gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset.