MIR941-3 Gene

HGNC Family Non-coding RNAs
Name microRNA 941-3
Description microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Summary
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nCirculating microRNAs have emerged as promising biomarkers in cardiovascular disease, and among these, MIR941-3 is now being investigated for its potential role in acute coronary syndrome (ACS). Recent studies utilizing gene chip technology have examined the expression profiles of various miRNAs—including MIR941-3—in patients with stable angina, non‐ST elevation ACS, and ST‐segment elevation myocardial infarction, suggesting that its expression levels could differentiate between these clinical entities and refine diagnostic accuracy."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nThe differential regulation observed for MIR941-3 in patients with distinct forms of coronary syndrome implies that this miRNA may be actively involved in the molecular processes underlying myocardial ischemia and related inflammatory responses. Its variable expression across ACS subtypes hints at a functional significance in modulating stress and injury responses within the cardiovascular system."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nAlthough the precise mechanistic pathways controlled by MIR941-3 remain to be fully elucidated, its candidacy as a biomarker not only supports improved diagnosis and risk stratification but also opens avenues for enhancing treatment and prevention strategies in coronary artery disease. Continued research into MIR941-3 will be key to understanding how its modulation can influence the progression of ACS and guide therapeutic interventions."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Ruina Bai, Qiaoning Yang, Ruixi Xi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-941 as a promising biomarker for acute coronary syndrome."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "BMC Cardiovasc Disord (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12872-017-0653-8"}], "href": "https://doi.org/10.1186/s12872-017-0653-8"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28830367"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28830367"}]}]}]}
Synonyms MIRN941-3
NCBI Gene ID 100126352
API
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Predicted Functions View MIR941-3's ARCHS4 Predicted Functions.
Co-expressed Genes View MIR941-3's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View MIR941-3's ARCHS4 Predicted Functions.

Functional Associations

MIR941-3 has 268 functional associations with biological entities spanning 3 categories (molecular profile, cell line, cell type or tissue, gene, protein or microRNA) extracted from 9 datasets.

Click the + buttons to view associations for MIR941-3 from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
CCLE Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR941-3 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
COSMIC Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR941-3 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
ENCODE Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR941-3 gene from the ENCODE Histone Modification Site Profiles dataset.
ENCODE Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR941-3 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
ENCODE Transcription Factor Targets transcription factors binding the promoter of MIR941-3 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
GTEx Tissue Gene Expression Profiles tissues with high or low expression of MIR941-3 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles dataset.
JASPAR Predicted Transcription Factor Targets transcription factors regulating expression of MIR941-3 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR941-3 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.
Roadmap Epigenomics Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR941-3 gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset.