MIR943 Gene

HGNC Family	Non-coding RNAs
Name	microRNA 943
Description	microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nIn allergic asthma, miR‐943-3p functions as a proinflammatory and pro-remodeling mediator by targeting secreted frizzled-related protein 4 (SFRP4), a key negative regulator of the Wnt signaling pathway. Upregulation of miR‐943-3p in both human patients and an ovalbumin-induced mouse model leads to downregulation of SFRP4, which in turn contributes to enhanced Wnt pathway activation, increased inflammatory cell infiltration, collagen deposition, subepithelial fibrosis, and smooth muscle thickening. Importantly, in vivo modulation experiments demonstrated that delivery of a miR‐943-3p agomir exacerbates airway pathology, whereas administration of its antagomir or SFRP4 supplementation can attenuate disease progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nA separate investigation focused on spermiogenesis explored mechanisms responsible for the stabilization of translationally repressed mRNAs during sperm development, though this study did not directly address or report a role for miR-943 in these processes. Consequently, despite the broader context of post-transcriptional regulation under examination, no functional involvement of miR-943 was identified in the stabilization of mRNAs essential for spermatid formation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Jian Shen, Jun Zhao, Qing-Yan Ye, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Interference of miR-943-3p with secreted frizzled-related proteins4 (SFRP4) in an asthma mouse model."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Tissue Res (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00441-019-03026-6"}], "href": "https://doi.org/10.1007/s00441-019-03026-6"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31101982"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31101982"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Yu Chen, Xiangzheng Zhang, Jiayin Jiang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Regulation of Miwi-mediated mRNA stabilization by Ck137956/Tssa is essential for male fertility."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "BMC Biol (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12915-023-01589-z"}], "href": "https://doi.org/10.1186/s12915-023-01589-z"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37069605"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37069605"}]}]}]}
Synonyms	MIRN943, HSA-MIR-943
NCBI Gene ID	100126332
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Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

MIR943 has 351 functional associations with biological entities spanning 6 categories (molecular profile, functional term, phrase or reference, chemical, disease, phenotype or trait, cell line, cell type or tissue, gene, protein or microRNA) extracted from 15 datasets.

Click the + buttons to view associations for MIR943 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

MIR943 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of MIR943 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of MIR943 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at MIR943 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR943 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of MIR943 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	GeneSigDB Published Gene Signatures	PubMedIDs of publications reporting gene signatures containing MIR943 from the GeneSigDB Published Gene Signatures dataset.
	GEO Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of MIR943 gene from the GEO Signatures of Differentially Expressed Genes for Small Molecules dataset.
	GTEx Tissue Gene Expression Profiles	tissues with high or low expression of MIR943 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles dataset.
	HuGE Navigator Gene-Phenotype Associations	phenotypes associated with MIR943 gene by text-mining GWAS publications from the HuGE Navigator Gene-Phenotype Associations dataset.
	JASPAR Predicted Transcription Factor Targets	transcription factors regulating expression of MIR943 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset.
	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	cell lines with high or low copy number of MIR943 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.
	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	cell lines with high or low expression of MIR943 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles dataset.
	MotifMap Predicted Transcription Factor Targets	transcription factors regulating expression of MIR943 gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset.
	Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles	cell types and tissues with high or low DNA methylation of MIR943 gene relative to other cell types and tissues from the Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles dataset.
	Roadmap Epigenomics Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at MIR943 gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset.