{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nMicroRNAs critically influence lung cancer progression by modulating the expression of key oncogenes and tumor suppressors. In this study, miR-9500 was identified as a novel microRNA that forms a conserved stem-loop structure and whose expression is markedly reduced in lung cancer tissues and cell lines relative to normal controls. Functional assays demonstrated that miR-9500 directly targets Akt1, a pivotal regulator of lung carcinogenesis, by binding to its 3′ untranslated region, leading to a significant decrease in Akt1 protein levels without notably affecting its mRNA expression. This post-transcriptional suppression of Akt1 by miR-9500 correlates with reduced cell proliferation, impaired cell cycle progression, and diminished cell migration in vitro, as well as inhibited tumor growth and metastasis in vivo. Collectively, these findings underscore the therapeutic potential of miR-9500 in lung cancer by exhibiting antiproliferative and anti-migratory effects through the targeted repression of Akt1."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "J K Yoo, H Y Jung, J M Lee, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The novel miR-9500 regulates the proliferation and migration of human lung cancer cells by targeting Akt1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Death Differ (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/cdd.2014.33"}], "href": "https://doi.org/10.1038/cdd.2014.33"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24658401"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24658401"}]}]}]}