MIR98 Gene

HGNC Family Non-coding RNAs
Name microRNA 98
Description microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Summary
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In some instances, altered miR‐98 levels have even been proposed as a potential biomarker in formalin‐fixed clinical specimens."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "19"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn addition to its roles in tumor cell biology, miR‐98 is an important regulator of immune and inflammatory responses. In immune cells such as T lymphocytes and epithelial cells, miR‐98 modulates the expression of key signaling intermediates—for example, by targeting components that regulate the levels of cytokine‐inducible proteins (CIS, SOCS4) or proteins involved in T cell receptor signaling. These actions are implicated in inflammatory conditions such as lupus and in epithelial responses to microbial challenges."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "20", "end_ref": "23"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond tumorigenesis per se, miR‐98 function has been linked to the cellular response to chemotherapeutic agents. In lung and ovarian cancer models, for instance, altered levels of miR‐98 (or its mature variant miR‐98‐5p) modulate drug sensitivity by regulating the expression of targets involved in apoptosis and drug transporter expression. In these settings, strategies that inhibit miR‐98 can elevate p53 levels and reverse chemoresistance, implying that manipulation of miR‐98 levels may enhance the efficacy of agents such as cisplatin."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "24"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nMiR‐98 also influences a number of non‐cancerous physiological and pathological processes. In bone biology, miR‐98 targets bone morphogenetic protein 2 (BMP2) to regulate osteogenic differentiation of mesenchymal stromal cells. Moreover, decreased miR‐98 levels have been implicated in intervertebral disc degeneration through perturbations in interleukin‐6/STAT3 signaling, while in gestational diabetes mellitus its up‐regulation appears to affect global DNA methylation by targeting Mecp2. Additionally, in neurodegenerative disease models miR‐98 modulates proteins such as sorting nexin 6 (SNX6) to influence amyloid‐β accumulation, and in myocarditis and renal ischemia–reperfusion injury it exerts anti‐apoptotic effects by modulating key apoptotic mediators like caspase‐3."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "26", "end_ref": "32"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Liqin Du, Jeoffrey J Schageman, Maria C Subauste, et al. 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Synonyms MIR-98, MIRN98, HSA-MIR-98
NCBI Gene ID 407054
API
Download Associations
Predicted Functions View MIR98's ARCHS4 Predicted Functions.
Co-expressed Genes View MIR98's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View MIR98's ARCHS4 Predicted Functions.

Functional Associations

MIR98 has 567 functional associations with biological entities spanning 6 categories (molecular profile, functional term, phrase or reference, disease, phenotype or trait, chemical, cell line, cell type or tissue, gene, protein or microRNA) extracted from 19 datasets.

Click the + buttons to view associations for MIR98 from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
CCLE Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR98 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
ChEA Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR98 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
ChEA Transcription Factor Targets transcription factors binding the promoter of MIR98 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
COMPARTMENTS Text-mining Protein Localization Evidence Scores cellular components co-occuring with MIR98 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
COSMIC Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR98 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
CTD Gene-Disease Associations diseases associated with MIR98 gene/protein from the curated CTD Gene-Disease Associations dataset.
DISEASES Text-mining Gene-Disease Association Evidence Scores diseases co-occuring with MIR98 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
ENCODE Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR98 gene from the ENCODE Histone Modification Site Profiles dataset.
ENCODE Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR98 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
ENCODE Transcription Factor Targets transcription factors binding the promoter of MIR98 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
GeneRIF Biological Term Annotations biological terms co-occuring with MIR98 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
GeneSigDB Published Gene Signatures PubMedIDs of publications reporting gene signatures containing MIR98 from the GeneSigDB Published Gene Signatures dataset.
GEO Signatures of Differentially Expressed Genes for Gene Perturbations gene perturbations changing expression of MIR98 gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset.
GEO Signatures of Differentially Expressed Genes for Small Molecules small molecule perturbations changing expression of MIR98 gene from the GEO Signatures of Differentially Expressed Genes for Small Molecules dataset.
HuGE Navigator Gene-Phenotype Associations phenotypes associated with MIR98 gene by text-mining GWAS publications from the HuGE Navigator Gene-Phenotype Associations dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR98 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.
KnockTF Gene Expression Profiles with Transcription Factor Perturbations transcription factor perturbations changing expression of MIR98 gene from the KnockTF Gene Expression Profiles with Transcription Factor Perturbations dataset.
MotifMap Predicted Transcription Factor Targets transcription factors regulating expression of MIR98 gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset.
TISSUES Text-mining Tissue Protein Expression Evidence Scores tissues co-occuring with MIR98 protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores dataset.