{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nResearch over the past decade has revealed that let‐7b functions as a pleiotropic regulator linking immune signaling with stress responses and cell–cell communication. In models of viral and bacterial infection as well as central nervous system injury, extracellular let‐7b can act as a signaling molecule by binding to RNA‐sensing receptors and modulating cytokine release. For example, let‐7b has been shown to regulate interferon‐β production in primate macrophages, in part through a negative feedback mechanism (see."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In response to genotoxic stress, p53‐dependent pathways also lead to a decrease in let‐7b expression, thereby influencing cell fate decisions (see."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " In the central nervous system, extracellular let‐7b activates Toll‐like receptor 7 and contributes to neurodegeneration, while similar functions extend into host defense under infectious conditions such as respiratory syncytial virus infection and H. pylori–mediated inflammation through regulation of pattern recognition receptors (see."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "3", "end_ref": "6"}]}, {"type": "t", "text": " Additionally, in leukemic cells bearing MLL‐rearrangements, downregulation of let‐7b appears to contribute to oncogenesis (see"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": ", underscoring its role as a regulator at the interface of inflammation and malignancy.\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its immunomodulatory capacity, let‐7b plays critical roles as a tumor suppressor and diagnostic biomarker in a broad spectrum of diseases. Reduced expression of let‐7b in lung, breast, and oral epithelial cancers is linked to tumor progression and adverse clinical outcomes (see."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "8", "end_ref": "10"}]}, {"type": "t", "text": " Therapeutically, systemic delivery of let‐7 together with other tumor‐suppressive microRNAs has been shown to inhibit tumor growth and improve survival in non‐small cell lung cancer models (see."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "11"}]}, {"type": "t", "text": " In the vasculature, low let‐7b levels correlate with increased angiogenesis and poorer prognosis, as evidenced by studies in lung cancer tissues (see."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "12"}]}, {"type": "t", "text": " Moreover, circulating exosomal let‐7b has been identified as a prognostic biomarker in multiple myeloma (see"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "13"}]}, {"type": "t", "text": ", while interactions with long noncoding RNAs such as HOST2 modulate its bioavailability in ovarian cancer (see"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "14"}]}, {"type": "t", "text": "and."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "15"}]}, {"type": "t", "text": " Additionally, increased let‐7b expression induced by changes in the cytoskeletal regulator cofilin‐1 has been implicated in reducing tumor invasion in lung cancer models (see."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "16"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nAt the molecular level, let‐7b exerts its tumor‐suppressive effects by post‐transcriptionally regulating key oncogenes and cell cycle components. In infectious contexts such as EV71 infection, upregulation of let‐7b suppresses cyclin D1, leading to cell cycle arrest (see."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "17"}]}, {"type": "t", "text": " In renal cell carcinoma, alterations in let‐7b expression influence chemotherapy sensitivity (see."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "18"}]}, {"type": "t", "text": " Mechanistically, efficient loading of let‐7b onto AGO2 via RNA‐binding proteins such as AUF1 facilitates target mRNA decay (see"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "19"}]}, {"type": "t", "text": ", and its ability to directly target oncogenes like c‐Myc in gastric cancer further underscores its regulatory importance (see."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "20"}]}, {"type": "t", "text": " Furthermore, modulation of the tumor microenvironment via macrophage polarization in prostate cancer (see"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "21"}]}, {"type": "t", "text": "and potential roles as a peripheral biomarker in mood disorders such as major depression (see"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "22"}]}, {"type": "t", "text": "highlight the diverse functions of let‐7b in controlling cell proliferation and differentiation. In glioma models, let‐7b targets cell cycle regulators like E2F2, thereby inhibiting tumor growth and stem‐like cell properties (see."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "23"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn addition, the diagnostic and prognostic potential of let‐7b has been explored in various biofluids. Circulating exosomal let‐7b levels are correlated with poor outcomes in multiple myeloma (see"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "24"}]}, {"type": "t", "text": ", while alterations in urinary let‐7b concentrations have been observed in renal cell carcinoma patients (see."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "25"}]}, {"type": "t", "text": " In neurodegenerative contexts, elevated levels of let‐7b in human cerebrospinal fluid—often associated with extracellular vesicles—mirror pathological processes in Alzheimer’s disease (see."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "26"}]}, {"type": "t", "text": " Preclinical models of endometriosis also demonstrate that local administration of let‐7b can reduce lesion size and modulate the expression of genes involved in estrogen signaling and inflammation (see."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "27"}]}, {"type": "t", "text": " Finally, in mucosal melanoma, dysregulation of let‐7b (together with let‐7c) is associated with poorer prognosis, underscoring its potential as a stratifying biomarker in cancer patients (see."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "28"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Kenneth W Witwer, Jeanne M Sisk, Lucio Gama, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA regulation of IFN-beta protein expression: rapid and sensitive modulation of the innate immune response."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Immunol (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4049/jimmunol.0902712"}], "href": "https://doi.org/10.4049/jimmunol.0902712"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20130213"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20130213"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Anthony D Saleh, Jason E Savage, Liu Cao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Cellular stress induced alterations in microRNA let-7a and let-7b expression are dependent on p53."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0024429"}], "href": "https://doi.org/10.1371/journal.pone.0024429"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22022355"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22022355"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Sabrina M Lehmann, Christina Krüger, Boyoun Park, et al. "}, {"type": "b", "children": [{"type": "t", "text": "An unconventional role for miRNA: let-7 activates Toll-like receptor 7 and causes neurodegeneration."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Neurosci (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nn.3113"}], "href": "https://doi.org/10.1038/nn.3113"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22610069"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22610069"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Guangwen Long, Feng Wang, Quanlu Duan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Circulating miR-30a, miR-195 and let-7b associated with acute myocardial infarction."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0050926"}], "href": "https://doi.org/10.1371/journal.pone.0050926"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23236408"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23236408"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Natalie J Thornburg, Sarah L Hayward, James E Crowe "}, {"type": "b", "children": [{"type": "t", "text": "Respiratory syncytial virus regulates human microRNAs by using mechanisms involving beta interferon and NF-κB."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "mBio (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/mBio.00220-12"}], "href": "https://doi.org/10.1128/mBio.00220-12"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23249809"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23249809"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Gui-gen Teng, Wei-hong Wang, Yun Dai, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Let-7b is involved in the inflammation and immune responses associated with Helicobacter pylori infection by targeting Toll-like receptor 4."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0056709"}], "href": "https://doi.org/10.1371/journal.pone.0056709"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23437218"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23437218"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "M Nishi, M Eguchi-Ishimae, Z Wu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Suppression of the let-7b microRNA pathway by DNA hypermethylation in infant acute lymphoblastic leukemia with MLL gene rearrangements."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Leukemia (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/leu.2012.242"}], "href": "https://doi.org/10.1038/leu.2012.242"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22918121"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22918121"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Edin Jusufović, Matija Rijavec, Dragan Keser, et al. "}, {"type": "b", "children": [{"type": "t", "text": "let-7b and miR-126 are down-regulated in tumor tissue and correlate with microvessel density and survival outcomes in non--small--cell lung cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0045577"}], "href": "https://doi.org/10.1371/journal.pone.0045577"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23029111"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23029111"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Lin Ma, Gui-Zhu Li, Zheng-Sheng Wu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Prognostic significance of let-7b expression in breast cancer and correlation to its target gene of BSG expression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Med Oncol (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s12032-013-0773-7"}], "href": "https://doi.org/10.1007/s12032-013-0773-7"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24264599"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24264599"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Ling Gao, Xiaolong Wang, Xiaofei Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "IGF-1R, a target of let-7b, mediates crosstalk between IRS-2/Akt and MAPK pathways to promote proliferation of oral squamous cell carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncotarget (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/oncotarget.1812"}], "href": "https://doi.org/10.18632/oncotarget.1812"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24810113"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24810113"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "A L Kasinski, K Kelnar, C Stahlhut, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A combinatorial microRNA therapeutics approach to suppressing non-small cell lung cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/onc.2014.282"}], "href": "https://doi.org/10.1038/onc.2014.282"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25174400"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25174400"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Mei-Hua Bao, Yi-Wen Zhang, Xiao-Ya Lou, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Protective effects of let-7a and let-7b on oxidized low-density lipoprotein induced endothelial cell injuries."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0106540"}], "href": "https://doi.org/10.1371/journal.pone.0106540"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25247304"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25247304"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Honghai Xu, Cong Liu, Yuelin Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Let-7b-5p regulates proliferation and apoptosis in multiple myeloma by targeting IGF1R."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Acta Biochim Biophys Sin (Shanghai) (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/abbs/gmu089"}], "href": "https://doi.org/10.1093/abbs/gmu089"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25274331"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25274331"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Yuan Gao, Hao Meng, Shupeng Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LncRNA-HOST2 regulates cell biological behaviors in epithelial ovarian cancer through a mechanism involving microRNA let-7b."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Mol Genet (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/hmg/ddu502"}], "href": "https://doi.org/10.1093/hmg/ddu502"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25292198"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25292198"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Kaiyao Hua, Xiaochong Deng, Jiashu Hu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long noncoding RNA HOST2, working as a competitive endogenous RNA, promotes STAT3-mediated cell proliferation and migration via decoying of let-7b in triple-negative breast cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Exp Clin Cancer Res (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s13046-020-01561-7"}], "href": "https://doi.org/10.1186/s13046-020-01561-7"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32248842"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32248842"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Cheng-Han Tsai, Liang-Ting Lin, Chung-Yih Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Over-expression of cofilin-1 suppressed growth and invasion of cancer cells is associated with up-regulation of let-7 microRNA."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochim Biophys Acta (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbadis.2015.01.007"}], "href": "https://doi.org/10.1016/j.bbadis.2015.01.007"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25597880"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25597880"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Xiling Du, Haipeng Wang, Fuhui Xu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Enterovirus 71 induces apoptosis of SH‑SY5Y human neuroblastoma cells through stimulation of endogenous microRNA let-7b expression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Med Rep (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/mmr.2015.3482"}], "href": "https://doi.org/10.3892/mmr.2015.3482"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25779425"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25779425"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Jingtao Peng, Ren Mo, Jian Ma, et al. "}, {"type": "b", "children": [{"type": "t", "text": "let-7b and let-7c are determinants of intrinsic chemoresistance in renal cell carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "World J Surg Oncol (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12957-015-0596-4"}], "href": "https://doi.org/10.1186/s12957-015-0596-4"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25951903"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25951903"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Je-Hyun Yoon, Myung Hyun Jo, Elizabeth J F White, et al. "}, {"type": "b", "children": [{"type": "t", "text": "AUF1 promotes let-7b loading on Argonaute 2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genes Dev (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1101/gad.263749.115"}], "href": "https://doi.org/10.1101/gad.263749.115"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26253535"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26253535"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Grazia Serino, Francesco Pesce, Fabio Sallustio, et al. "}, {"type": "b", "children": [{"type": "t", "text": "In a retrospective international study, circulating miR-148b and let-7b were found to be serum markers for detecting primary IgA nephropathy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Kidney Int (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ki.2015.333"}], "href": "https://doi.org/10.1038/ki.2015.333"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26581012"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26581012"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "Zhigang Wang, Lu Xu, Yinying Hu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miRNA let-7b modulates macrophage polarization and enhances tumor-associated macrophages to promote angiogenesis and mobility in prostate cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/srep25602"}], "href": "https://doi.org/10.1038/srep25602"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27157642"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27157642"}]}, {"type": "r", "ref": 22, "children": [{"type": "t", "text": "A Gururajan, M E Naughton, K A Scott, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNAs as biomarkers for major depression: a role for let-7b and let-7c."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Transl Psychiatry (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/tp.2016.131"}], "href": "https://doi.org/10.1038/tp.2016.131"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27483380"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27483380"}]}, {"type": "r", "ref": 23, "children": [{"type": "t", "text": "Hang Song, Yao Zhang, Na Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Let-7b inhibits the malignant behavior of glioma cells and glioma stem-like cells via downregulation of E2F2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Physiol Biochem (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s13105-016-0512-6"}], "href": "https://doi.org/10.1007/s13105-016-0512-6"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27520092"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27520092"}]}, {"type": "r", "ref": 24, "children": [{"type": "t", "text": "Salomon Manier, Chia-Jen Liu, Hervé Avet-Loiseau, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Prognostic role of circulating exosomal miRNAs in multiple myeloma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Blood (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1182/blood-2016-09-742296"}], "href": "https://doi.org/10.1182/blood-2016-09-742296"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28213378"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28213378"}]}, {"type": "r", "ref": 25, "children": [{"type": "t", "text": "Michal Fedorko, Jaroslav Juracek, Michal Stanik, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Detection of let-7 miRNAs in urine supernatant as potential diagnostic approach in non-metastatic clear-cell renal cell carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Med (Zagreb) (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.11613/BM.2017.043"}], "href": "https://doi.org/10.11613/BM.2017.043"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28694731"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28694731"}]}, {"type": "r", "ref": 26, "children": [{"type": "t", "text": "Katja Derkow, Rosa Rössling, Carola Schipke, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Distinct expression of the neurotoxic microRNA family let-7 in the cerebrospinal fluid of patients with Alzheimer's disease."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0200602"}], "href": "https://doi.org/10.1371/journal.pone.0200602"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30011310"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30011310"}]}, {"type": "r", "ref": 27, "children": [{"type": "t", "text": "Cagdas Sahin, Ramanaiah Mamillapalli, Kyong W Yi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "microRNA Let-7b: A Novel treatment for endometriosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Mol Med (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/jcmm.13807"}], "href": "https://doi.org/10.1111/jcmm.13807"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30063121"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30063121"}]}, {"type": "r", "ref": 28, "children": [{"type": "t", "text": "Huan Tang, Meng Ma, Jie Dai, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-let-7b and miR-let-7c suppress tumourigenesis of human mucosal melanoma and enhance the sensitivity to chemotherapy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Exp Clin Cancer Res (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s13046-019-1190-3"}], "href": "https://doi.org/10.1186/s13046-019-1190-3"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31118065"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31118065"}]}]}]}