| Name | MIRLET7B host gene |
| Description | Predicted to be involved in miRNA-mediated post-transcriptional gene silencing. Predicted to be part of RISC complex. Implicated in lung cancer. [provided by Alliance of Genome Resources, Mar 2025] |
| Summary |
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nKIAA1429, a critical component of the m6A methyltransferase complex, plays pivotal roles in regulating RNA processing events that underpin diverse developmental and differentiation processes. In oocytes, KIAA1429 is essential for the proper execution of RNA metabolism and alternative splicing events required for folliculogenesis and meiotic resumption. Its depletion leads to the accumulation of aberrant transcripts, culminating in defective follicular development and impaired oocyte maturation, which ultimately results in female infertility."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "In spermatogonia, KIAA1429 expression is markedly upregulated by melatonin treatment. This upregulation enhances overall m6A levels on RNAs, thereby promoting cell viability and proliferation while concurrently reducing apoptosis. The modulation of m6A methylation by KIAA1429 activates key signaling pathways, notably the PI3K/AKT axis, which is central to the regulation of spermatogonia activity. Interference with KIAA1429 expression disrupts these processes, underscoring its regulatory importance in testicular function."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "In the context of infantile hemangiomas, KIAA1429 exerts a methylation-independent function by facilitating the phenotypic transition of hemangioma endothelial cells towards a more stem cell–like, fibroblast phenotype. This transition promotes differentiation and effectively curbs cellular proliferation, contributing to the regression of hemangiomas. These findings suggest that beyond its enzymatic role in m6A modification, KIAA1429 also modulates endothelial cell plasticity, offering potential as a therapeutic target for vascular tumors."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Yue Hu, Zhangyi Ouyang, Xuesong Sui, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Oocyte competence is maintained by m"}, {"type": "a", "children": [{"type": "t", "text": "sup"}], "href": "sup"}, {"type": "t", "text": "6"}, {"type": "a", "children": [{"type": "t", "text": "/sup"}], "href": "/sup"}, {"type": "t", "text": "A methyltransferase KIAA1429-mediated RNA metabolism during mouse follicular development."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Death Differ (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41418-020-0516-1"}], "href": "https://doi.org/10.1038/s41418-020-0516-1"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32094512"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32094512"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Chang-Long Xu, Qing-Ying Tan, Hua Yang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Melatonin enhances spermatogonia activity through promoting KIAA1429-mediated m"}, {"type": "a", "children": [{"type": "t", "text": "sup"}], "href": "sup"}, {"type": "t", "text": "6"}, {"type": "a", "children": [{"type": "t", "text": "/sup"}], "href": "/sup"}, {"type": "t", "text": "A deposition to activate the PI3K/AKT signaling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Reprod Biol (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.repbio.2022.100681"}], "href": "https://doi.org/10.1016/j.repbio.2022.100681"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35987159"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35987159"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Luying Wang, Yuqing Zou, Zhishun Huang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "KIAA1429 promotes infantile hemangioma regression by facilitating the stemness of hemangioma endothelial cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Sci (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/cas.15708"}], "href": "https://doi.org/10.1111/cas.15708"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36572002"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36572002"}]}]}]}
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| Synonyms | LINC-PPARA |
| NCBI Gene ID | 400931 |
| API | |
| Download Associations | |
| Predicted Functions |
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| Co-expressed Genes |
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| Expression in Tissues and Cell Lines |
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MIRLET7BHG has 1,079 functional associations with biological entities spanning 6 categories (molecular profile, organism, disease, phenotype or trait, chemical, cell line, cell type or tissue, gene, protein or microRNA) extracted from 25 datasets.
Click the + buttons to view associations for MIRLET7BHG from the datasets below.
If available, associations are ranked by standardized value
| Dataset | Summary | |
|---|---|---|
| Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles | tissues with high or low expression of MIRLET7BHG gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset. | |
| Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq | tissue samples with high or low expression of MIRLET7BHG gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset. | |
| Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles | tissues with high or low expression of MIRLET7BHG gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset. | |
| CCLE Cell Line Gene CNV Profiles | cell lines with high or low copy number of MIRLET7BHG gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset. | |
| CCLE Cell Line Gene Expression Profiles | cell lines with high or low expression of MIRLET7BHG gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset. | |
| CellMarker Gene-Cell Type Associations | cell types associated with MIRLET7BHG gene from the CellMarker Gene-Cell Type Associations dataset. | |
| COSMIC Cell Line Gene CNV Profiles | cell lines with high or low copy number of MIRLET7BHG gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset. | |
| ENCODE Histone Modification Site Profiles | histone modification site profiles with high histone modification abundance at MIRLET7BHG gene from the ENCODE Histone Modification Site Profiles dataset. | |
| ENCODE Transcription Factor Binding Site Profiles | transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIRLET7BHG gene from the ENCODE Transcription Factor Binding Site Profiles dataset. | |
| ENCODE Transcription Factor Targets | transcription factors binding the promoter of MIRLET7BHG gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset. | |
| GEO Signatures of Differentially Expressed Genes for Diseases | disease perturbations changing expression of MIRLET7BHG gene from the GEO Signatures of Differentially Expressed Genes for Diseases dataset. | |
| GEO Signatures of Differentially Expressed Genes for Gene Perturbations | gene perturbations changing expression of MIRLET7BHG gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset. | |
| GEO Signatures of Differentially Expressed Genes for Small Molecules | small molecule perturbations changing expression of MIRLET7BHG gene from the GEO Signatures of Differentially Expressed Genes for Small Molecules dataset. | |
| GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations | transcription factor perturbations changing expression of MIRLET7BHG gene from the GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations dataset. | |
| GEO Signatures of Differentially Expressed Genes for Viral Infections | virus perturbations changing expression of MIRLET7BHG gene from the GEO Signatures of Differentially Expressed Genes for Viral Infections dataset. | |
| GTEx Tissue-Specific Aging Signatures | tissue samples with high or low expression of MIRLET7BHG gene relative to other tissue samples from the GTEx Tissue-Specific Aging Signatures dataset. | |
| GWASdb SNP-Disease Associations | diseases associated with MIRLET7BHG gene in GWAS and other genetic association datasets from the GWASdb SNP-Disease Associations dataset. | |
| GWASdb SNP-Phenotype Associations | phenotypes associated with MIRLET7BHG gene in GWAS datasets from the GWASdb SNP-Phenotype Associations dataset. | |
| HPA Tissue Protein Expression Profiles | tissues with high or low expression of MIRLET7BHG protein relative to other tissues from the HPA Tissue Protein Expression Profiles dataset. | |
| Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles | cell lines with high or low copy number of MIRLET7BHG gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset. | |
| Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles | cell lines with high or low expression of MIRLET7BHG gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles dataset. | |
| MotifMap Predicted Transcription Factor Targets | transcription factors regulating expression of MIRLET7BHG gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset. | |
| MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations | gene perturbations changing expression of MIRLET7BHG gene from the MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations dataset. | |
| Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles | cell types and tissues with high or low DNA methylation of MIRLET7BHG gene relative to other cell types and tissues from the Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles dataset. | |
| Roadmap Epigenomics Histone Modification Site Profiles | histone modification site profiles with high histone modification abundance at MIRLET7BHG gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset. | |
