{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRecent findings have revealed that JADE2, an epigenetic regulatory factor, plays a pivotal role in neural differentiation by modulating key chromatin-modifying enzymes. In embryonic stem cells, JADE2 acts as an E3 ubiquitin ligase that targets the histone demethylase LSD1 for degradation via the ubiquitin-proteasome pathway, thereby lifting the repression of differentiation‐associated genes and promoting a rapid switch toward the neural lineage. This “antibraking” function ensures that cells can quickly re-establish a new epigenetic landscape without resorting to slower, transcription‐dependent mechanisms."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nMoreover, JADE2 has been identified as indispensable for the maintenance of synaptic plasticity in the hippocampus, a crucial process underlying cognitive functions. By regulating chromatin dynamics in postmitotic neurons, JADE2 supports the synaptic adaptations necessary for learning and memory, further highlighting its role as a key mediator of neuronal integrity beyond early developmental stages."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn a related context of post-transcriptional and epigenetic regulation, integrative studies in thyroid cancer have uncovered a complex network where long non-coding RNAs, such as SPTY2D1-AS1, counteract oncogenic microRNAs like miR-221. Although this study primarily focused on RNA regulatory interactions, it underscores the broader significance of rapid post-transcriptional adaptations in disease contexts. Such mechanisms mirror the swift regulatory role observed for JADE2 in neural systems and may hint at potential therapeutic intersections between chromatin modifiers and RNA networks in oncogenesis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Xiao Han, Bin Gui, Cong Xiong, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Destabilizing LSD1 by Jade-2 promotes neurogenesis: an antibraking system in neural development."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.molcel.2014.06.006"}], "href": "https://doi.org/10.1016/j.molcel.2014.06.006"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25018020"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25018020"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Minghua Fan, Yongqing Liu, Yongfeng Shang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "JADE2 Is Essential for Hippocampal Synaptic Plasticity and Cognitive Functions in Mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biol Psychiatry (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.biopsych.2022.05.021"}], "href": "https://doi.org/10.1016/j.biopsych.2022.05.021"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36008159"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36008159"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Julia Ramírez-Moya, León Wert-Lamas, Adrián Acuña-Ruíz, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of an interactome network between lncRNAs and miRNAs in thyroid cancer reveals SPTY2D1-AS1 as a new tumor suppressor."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41598-022-11725-4"}], "href": "https://doi.org/10.1038/s41598-022-11725-4"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35562181"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35562181"}]}]}]}