MMAB Gene

Name	methylmalonic aciduria (cobalamin deficiency) cblB type
Description	This gene encodes a protein that catalyzes the final step in the conversion of vitamin B(12) into adenosylcobalamin (AdoCbl), a vitamin B12-containing coenzyme for methylmalonyl-CoA mutase. Mutations in the gene are the cause of vitamin B12-dependent methylmalonic aciduria linked to the cblB complementation group. Alternatively spliced transcript variants have been found. [provided by RefSeq, Apr 2011]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nMMAB encodes the mitochondrial enzyme ATP:cob(I)alamin adenosyltransferase, which catalyzes the final step in converting vitamin B12 into its active coenzyme form, adenosylcobalamin. This cofactor is essential for methylmalonyl‐CoA mutase (MCM) activity in the catabolism of certain amino acids and lipids. Defects in MMAB impair adenosylcobalamin synthesis and underlie the cblB complementation type of methylmalonic aciduria, as documented in genetic and clinical studies of affected patients."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "4"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBiochemical and structural investigations have demonstrated that MMAB not only catalyzes the adenosylation of reduced cob(I)alamin with ATP but also serves as an escort, directly delivering adenosylcobalamin to MCM. Detailed mutagenesis and kinetic analyses have elucidated the active‐site architecture, substrate binding properties, and the unique ATP-dependent cofactor release mechanism critical for enzyme function. These studies have highlighted the importance of conserved residues and proper protein folding for optimal catalysis."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "5", "end_ref": "8"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nPathogenic mutations in MMAB—including point mutations, splicing defects, and truncations—have been shown to disrupt ligand binding, compromise cofactor sequestration, and reduce protein stability. Such defects in the enzyme’s catalytic ability manifest as severe clinical phenotypes of methylmalonic aciduria, with analyses revealing altered kinetic parameters and diminished interaction with ATP and cobalamin derivatives."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}, {"type": "fg_f", "ref": "9"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its canonical role in vitamin B12 metabolism, MMAB has emerged as a potential regulator of lipid homeostasis. Genome-wide association and allelic expression studies have linked MMAB polymorphisms to variations in HDL-cholesterol levels, with hepatic MMAB expression being modulated by SREBP2. Altered MMAB activity appears to affect cholesterol biosynthesis indirectly by promoting the accumulation of metabolic intermediates that inhibit HMG-CoA reductase, thereby influencing LDL receptor expression and cholesterol uptake."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "10", "end_ref": "13"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nFinally, variation in MMAB is also implicated in the inter-individual differences in overall vitamin B12 status, as genetic polymorphisms in this gene correlate with biomarkers of B12 deficiency in population studies, underscoring its central role in maintaining metabolic homeostasis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "14"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Nicole A Leal, Sanghee D Park, Peter E Kima, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of the human and bovine ATP:Cob(I)alamin adenosyltransferase cDNAs based on complementation of a bacterial mutant."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M212739200"}], "href": "https://doi.org/10.1074/jbc.M212739200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12514191"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12514191"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Siriporn Keeratichamroen, James R Ketudat Cairns, Phannee Sawangareetrakul, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Novel mutations found in two genes of thai patients with isolated methylmalonic acidemia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Genet (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s10528-007-9085-y"}], "href": "https://doi.org/10.1007/s10528-007-9085-y"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17410422"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17410422"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Friederike Hörster, Matthias R Baumgartner, Caroline Viardot, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long-term outcome in methylmalonic acidurias is influenced by the underlying defect (mut0, mut-, cblA, cblB)."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Pediatr Res (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1203/PDR.0b013e3180a0325f"}], "href": "https://doi.org/10.1203/PDR.0b013e3180a0325f"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17597648"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17597648"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "B Merinero, B Pérez, C Pérez-Cerdá, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Methylmalonic acidaemia: examination of genotype and biochemical data in 32 patients belonging to mut, cblA or cblB complementation group."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Inherit Metab Dis (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s10545-007-0667-y"}], "href": "https://doi.org/10.1007/s10545-007-0667-y"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17957493"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17957493"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Nicole A Leal, Horatiu Olteanu, Ruma Banerjee, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Human ATP:Cob(I)alamin adenosyltransferase and its interaction with methionine synthase reductase."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M405449200"}], "href": "https://doi.org/10.1074/jbc.M405449200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15347655"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15347655"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Chenguang Fan, Thomas A Bobik "}, {"type": "b", "children": [{"type": "t", "text": "Functional characterization and mutation analysis of human ATP:Cob(I)alamin adenosyltransferase."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochemistry (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1021/bi800084a"}], "href": "https://doi.org/10.1021/bi800084a"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18251506"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18251506"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Ana Jorge-Finnigan, Cristina Aguado, Rocio Sánchez-Alcudia, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Functional and structural analysis of five mutations identified in methylmalonic aciduria cblB type."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Mutat (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/humu.21307"}], "href": "https://doi.org/10.1002/humu.21307"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20556797"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20556797"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Michael Lofgren, Ruma Banerjee "}, {"type": "b", "children": [{"type": "t", "text": "Loss of allostery and coenzyme B12 delivery by a pathogenic mutation in adenosyltransferase."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochemistry (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1021/bi2006306"}], "href": "https://doi.org/10.1021/bi2006306"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21604717"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21604717"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Margaret L Illson, Laura Dempsey-Nunez, Jana Kent, et al. "}, {"type": "b", "children": [{"type": "t", "text": "High resolution melting analysis of the MMAB gene in cblB patients and in those with undiagnosed methylmalonic aciduria."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Genet Metab (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ymgme.2013.04.020"}], "href": "https://doi.org/10.1016/j.ymgme.2013.04.020"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23707710"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23707710"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Mireia Junyent, Laurence D Parnell, Chao-Qiang Lai, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Novel variants at KCTD10, MVK, and MMAB genes interact with dietary carbohydrates to modulate HDL-cholesterol concentrations in the Genetics of Lipid Lowering Drugs and Diet Network Study."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Clin Nutr (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3945/ajcn.2009.27738"}], "href": "https://doi.org/10.3945/ajcn.2009.27738"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19605566"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19605566"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Marie P Fogarty, Rui Xiao, Ludmila Prokunina-Olsson, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Allelic expression imbalance at high-density lipoprotein cholesterol locus MMAB-MVK."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Mol Genet (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/hmg/ddq067"}], "href": "https://doi.org/10.1093/hmg/ddq067"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20159775"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20159775"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Jie Sun, Yun Qian, Yue Jiang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Association of KCTD10, MVK, and MMAB polymorphisms with dyslipidemia and coronary heart disease in Han Chinese population."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Lipids Health Dis (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12944-016-0348-7"}], "href": "https://doi.org/10.1186/s12944-016-0348-7"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27716295"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27716295"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Leigh Goedeke, Alberto Canfrán-Duque, Noemi Rotllan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MMAB promotes negative feedback control of cholesterol homeostasis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41467-021-26787-7"}], "href": "https://doi.org/10.1038/s41467-021-26787-7"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34750386"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34750386"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Anupriya Dalmia, Marie-Joe Dib, Hannah Maude, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A genetic epidemiological study in British adults and older adults shows a high heritability of the combined indicator of vitamin B"}, {"type": "a", "children": [{"type": "t", "text": "sub"}], "href": "sub"}, {"type": "t", "text": "12"}, {"type": "a", "children": [{"type": "t", "text": "/sub"}], "href": "/sub"}, {"type": "t", "text": " status (cB"}, {"type": "a", "children": [{"type": "t", "text": "sub"}], "href": "sub"}, {"type": "t", "text": "12"}, {"type": "a", "children": [{"type": "t", "text": "/sub"}], "href": "/sub"}, {"type": "t", "text": ") and connects B"}, {"type": "a", "children": [{"type": "t", "text": "sub"}], "href": "sub"}, {"type": "t", "text": "12"}, {"type": "a", "children": [{"type": "t", "text": "/sub"}], "href": "/sub"}, {"type": "t", "text": " status with utilization of mitochondrial substrates and energy metabolism."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Nutr Biochem (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.jnutbio.2019.04.008"}], "href": "https://doi.org/10.1016/j.jnutbio.2019.04.008"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31203192"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31203192"}]}]}]}
Synonyms	cblB, CFAP23, COB
Proteins	MMAB_HUMAN
NCBI Gene ID	326625
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

MMAB has 8,685 functional associations with biological entities spanning 9 categories (molecular profile, organism, chemical, disease, phenotype or trait, functional term, phrase or reference, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 128 datasets.

Click the + buttons to view associations for MMAB from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

MMAB Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of MMAB gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of MMAB gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of MMAB gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of MMAB gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of MMAB gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of MMAB gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of MMAB gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of MMAB gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of MMAB gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of MMAB gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with MMAB protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with MMAB gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of MMAB gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of MMAB gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of MMAB gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	ClinVar Gene-Phenotype Associations	phenotypes associated with MMAB gene from the curated ClinVar Gene-Phenotype Associations dataset.
	ClinVar Gene-Phenotype Associations 2025	phenotypes associated with MMAB gene from the curated ClinVar Gene-Phenotype Associations 2025 dataset.
	CM4AI U2OS Cell Map Protein Localization Assemblies	assemblies containing MMAB protein from integrated AP-MS and IF data from the CM4AI U2OS Cell Map Protein Localization Assemblies dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing MMAB protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing MMAB protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores	cellular components containing MMAB protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	cellular components containing MMAB protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with MMAB protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with MMAB protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of MMAB gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with MMAB gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with MMAB gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with MMAB gene/protein from the curated CTD Gene-Disease Associations dataset.
	dbGAP Gene-Trait Associations	traits associated with MMAB gene in GWAS and other genetic association datasets from the dbGAP Gene-Trait Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of MMAB protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by MMAB gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Curated Gene-Disease Association Evidence Scores	diseases involving MMAB gene from the DISEASES Curated Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Curated Gene-Disease Association Evidence Scores 2025	diseases involving MMAB gene from the DISEASES Curated Gene-Disease Association Evidence Scores 2025 dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with MMAB gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with MMAB gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with MMAB gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with MMAB gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with MMAB gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	DrugBank Drug Targets	interacting drugs for MMAB protein from the curated DrugBank Drug Targets dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at MMAB gene from the ENCODE Histone Modification Site Profiles dataset.