MOB1A Gene

HGNC Family	MOB kinase activators (MOB)
Name	MOB kinase activator 1A
Description	The protein encoded by this gene is a component of the Hippo signaling pathway, which controls organ size and tumor growth by enhancing apoptosis. Loss of the encoded protein results in cell proliferation and cancer formation. The encoded protein is also involved in the control of microtubule stability during cytokinesis. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nMOB1A, a highly conserved adaptor protein, plays a central role in the Hippo signaling cascade that governs cell proliferation, apoptosis, and organ size. Early studies in Drosophila revealed that the ortholog of human MOB1A (also known as Mats1) stimulates the activity of the LATS/Warts kinase, thereby promoting growth inhibition and tumor suppression by coordinating cell proliferation and apoptosis. Consistent with these findings in flies, analyses in human cancer specimens—including colorectal tumors—demonstrated that reduced expression of MOB1A associates with aggressive tumor growth, invasion, and metastasis, strengthening its role as a tumor suppressor in diverse cellular contexts."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "3"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBiochemical and structural investigations have elucidated that MOB1A functions by linking upstream kinases, such as MST1/2, with downstream effectors like LATS1/2 and NDR1/2. MOB1A achieves this through a phosphopeptide-binding interface that not only enables it to serve as a scaffold for efficient trans-phosphorylation reactions but also ensures proper activation of downstream kinases in the Hippo pathway. In addition, studies have shown that modification of MOB1A—whether by proteolytic degradation mediated by RING ligases like praja2, by acetylation events that stabilize the molecule, or by dephosphorylation via tyrosine phosphatases—further regulates its binding capacity and function. These multiple layers of regulation underscore MOB1A’s capacity to integrate various signaling inputs and maintain cellular homeostasis."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "4", "end_ref": "11"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its core function in the Hippo pathway, MOB1A is critical for proper cell division. It localizes to key mitotic structures such as spindle poles, kinetochores, and the spindle midzone, thereby coordinating mitotic exit and cytokinesis. Disruptions in MOB1A function have been linked to defects in midbody abscission and centriole rejoining, which can contribute to chromosomal instability. Furthermore, emerging evidence indicates that MOB1A is a target of additional regulatory mechanisms involving post‐transcriptional control by factors like MSI2 and interactions with non–Hippo signaling complexes, as observed in pancreatic ductal adenocarcinoma and during host–pathogen interactions with Legionella pneumophila. Notably, aberrant delivery of regulatory RNAs that scaffold MOB1A degradation has been implicated in colorectal cancer progression, further highlighting the clinical significance of MOB1A-mediated Hippo pathway regulation."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "12", "end_ref": "15"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Zhi-Chun Lai, Xiaomu Wei, Takeshi Shimizu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Control of cell proliferation and apoptosis by mob as tumor suppressor, mats."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cell.2004.12.036"}], "href": "https://doi.org/10.1016/j.cell.2004.12.036"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15766530"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15766530"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Yoshimasa Kosaka, Koshi Mimori, Fumiaki Tanaka, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Clinical significance of the loss of MATS1 mRNA expression in colorectal cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Oncol (2007)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17611689"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17611689"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Annabelle Chow, Yawei Hao, Xiaolong Yang "}, {"type": "b", "children": [{"type": "t", "text": "Molecular characterization of human homologs of yeast MOB1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Cancer (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/ijc.24878"}], "href": "https://doi.org/10.1002/ijc.24878"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19739119"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19739119"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Luca Lignitto, Antonietta Arcella, Maria Sepe, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Proteolysis of MOB1 by the ubiquitin ligase praja2 attenuates Hippo signalling and supports glioblastoma growth."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ncomms2791"}], "href": "https://doi.org/10.1038/ncomms2791"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23652010"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23652010"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Hyo-Young Chung, Meigang Gu, Eugen Buehler, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Stable MOB1 interaction with Hippo/MST is not essential for development and tissue growth control."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41467-017-00795-y"}], "href": "https://doi.org/10.1038/s41467-017-00795-y"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28947795"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28947795"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Jiaqi Jin, Lei Zhang, Xueying Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Oxidative stress-CBP axis modulates MOB1 acetylation and activates the Hippo signaling pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nucleic Acids Res (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/nar/gkac189"}], "href": "https://doi.org/10.1093/nar/gkac189"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35349706"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35349706"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Parveen Kumar, Prathyusha Munnangi, Kvs Rammohan Chowdary, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A Human Tyrosine Phosphatase Interactome Mapped by Proteomic Profiling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Proteome Res (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1021/acs.jproteome.7b00065"}], "href": "https://doi.org/10.1021/acs.jproteome.7b00065"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28675297"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28675297"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Pei-Chung Lee, Ksenia Beyrakhova, Caishuang Xu, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Human Mob1 proteins are required for cytokinesis by controlling microtubule stability."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Sci (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1242/jcs.097147"}], "href": "https://doi.org/10.1242/jcs.097147"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22454515"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22454515"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Haiyan Yang, Jiong Hu, Jingde Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "RNA-binding protein Musashi2 regulates Hippo signaling via SAV1 and MOB1 in pancreatic cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Med Oncol (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s12032-020-01384-8"}], "href": "https://doi.org/10.1007/s12032-020-01384-8"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32780197"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32780197"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Peng Yang, Dongsheng Zhang, Tuo Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "CAF-derived exosomal WEE2-AS1 facilitates colorectal cancer progression via promoting degradation of MOB1A to inhibit the Hippo pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Death Dis (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41419-022-05240-7"}], "href": "https://doi.org/10.1038/s41419-022-05240-7"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36123327"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36123327"}]}]}]}
Synonyms	MOB4B, MATS1, C2ORF6, MOBKL1B, MOBK1B
Proteins	MOB1A_HUMAN
NCBI Gene ID	55233
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

MOB1A has 6,550 functional associations with biological entities spanning 9 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 123 datasets.

Click the + buttons to view associations for MOB1A from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

MOB1A Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of MOB1A gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of MOB1A gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of MOB1A gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of MOB1A gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of MOB1A gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of MOB1A gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of MOB1A gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of MOB1A gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of MOB1A gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of MOB1A gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of MOB1A gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of MOB1A gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with MOB1A gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of MOB1A gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of MOB1A gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of MOB1A gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	gene perturbations changing expression of MOB1A gene from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of MOB1A gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing MOB1A protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing MOB1A protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with MOB1A protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with MOB1A protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of MOB1A gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with MOB1A gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Disease Associations	diseases associated with MOB1A gene/protein from the curated CTD Gene-Disease Associations dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by MOB1A gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with MOB1A gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with MOB1A gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with MOB1A gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with MOB1A gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with MOB1A gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at MOB1A gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of MOB1A gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of MOB1A gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing MOB1A from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GDSC Cell Line Gene Expression Profiles	cell lines with high or low expression of MOB1A gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.
	GeneRIF Biological Term Annotations	biological terms co-occuring with MOB1A gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
	GeneSigDB Published Gene Signatures	PubMedIDs of publications reporting gene signatures containing MOB1A from the GeneSigDB Published Gene Signatures dataset.
	GEO Signatures of Differentially Expressed Genes for Diseases	disease perturbations changing expression of MOB1A gene from the GEO Signatures of Differentially Expressed Genes for Diseases dataset.
	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	gene perturbations changing expression of MOB1A gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset.