MPC1L Gene

Name	mitochondrial pyruvate carrier 1-like
Description	Predicted to enable pyruvate transmembrane transporter activity. Involved in mitochondrial pyruvate transmembrane transport. Located in mitochondrial inner membrane. [provided by Alliance of Genome Resources, Mar 2025]
Synonyms	SLC54A3
Proteins	MPC1L_HUMAN
NCBI Gene ID	347411
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Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

MPC1L has 576 functional associations with biological entities spanning 6 categories (functional term, phrase or reference, chemical, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 37 datasets.

Click the + buttons to view associations for MPC1L from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

MPC1L Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of MPC1L gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of MPC1L gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of MPC1L gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	gene perturbations changing expression of MPC1L gene from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing MPC1L protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with MPC1L protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of MPC1L gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	DGIdb Drug Targets 2026	interacting drugs for MPC1L protein from the DGIdb Drug Targets 2026 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with MPC1L gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	gene perturbations changing expression of MPC1L gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset.
	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	kinase perturbations changing expression of MPC1L gene from the GEO Signatures of Differentially Expressed Genes for Kinase Perturbations dataset.
	GO Biological Process Annotations 2015	biological processes involving MPC1L gene from the curated GO Biological Process Annotations 2015 dataset.
	GO Biological Process Annotations 2023	biological processes involving MPC1L gene from the curated GO Biological Process Annotations 2023 dataset.
	GO Biological Process Annotations 2025	biological processes involving MPC1L gene from the curated GO Biological Process Annotations2025 dataset.
	GO Cellular Component Annotations 2015	cellular components containing MPC1L protein from the curated GO Cellular Component Annotations 2015 dataset.
	GO Cellular Component Annotations 2023	cellular components containing MPC1L protein from the curated GO Cellular Component Annotations 2023 dataset.
	GO Cellular Component Annotations 2025	cellular components containing MPC1L protein from the curated GO Cellular Component Annotations 2025 dataset.
	GO Molecular Function Annotations 2023	molecular functions performed by MPC1L gene from the curated GO Molecular Function Annotations 2023 dataset.
	GO Molecular Function Annotations 2025	molecular functions performed by MPC1L gene from the curated GO Molecular Function Annotations 2025 dataset.
	GTEx Tissue Gene Expression Profiles	tissues with high or low expression of MPC1L gene relative to other tissues from the GTEx Tissue Gene Expression Profiles dataset.
	GTEx Tissue Gene Expression Profiles 2023	tissues with high or low expression of MPC1L gene relative to other tissues from the GTEx Tissue Gene Expression Profiles 2023 dataset.
	InterPro Predicted Protein Domain Annotations	protein domains predicted for MPC1L protein from the InterPro Predicted Protein Domain Annotations dataset.
	JASPAR Predicted Human Transcription Factor Targets 2025	transcription factors regulating expression of MPC1L gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Human Transcription Factor Targets dataset.
	JASPAR Predicted Mouse Transcription Factor Targets 2025	transcription factors regulating expression of MPC1L gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Mouse Transcription Factor Targets 2025 dataset.
	KEGG Pathways 2026	pathways involving MPC1L protein from the KEGG Pathways 2026 dataset.
	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	cell lines with high or low copy number of MPC1L gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.
	LOCATE Predicted Protein Localization Annotations	cellular components predicted to contain MPC1L protein from the LOCATE Predicted Protein Localization Annotations dataset.
	MotifMap Predicted Transcription Factor Targets	transcription factors regulating expression of MPC1L gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset.
	Reactome Pathways 2024	pathways involving MPC1L protein from the Reactome Pathways 2024 dataset.
	Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles	cell types and tissues with high or low DNA methylation of MPC1L gene relative to other cell types and tissues from the Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles dataset.
	Rummagene Transcription Factor Associations 2026	transcription factors regulating expression of MPC1L gene from the Rummagene Transcription Factor Associations 2026 dataset.
	RummaGEO Drug Perturbation Signatures	drug perturbations changing expression of MPC1L gene from the RummaGEO Drug Perturbation Signatures dataset.
	RummaGEO Gene Perturbation Signatures	gene perturbations changing expression of MPC1L gene from the RummaGEO Gene Perturbation Signatures dataset.
	TargetScan Predicted Conserved microRNA Targets	microRNAs regulating expression of MPC1L gene predicted using conserved miRNA seed sequences from the TargetScan Predicted Conserved microRNA Targets dataset.
	TargetScan Predicted Nonconserved microRNA Targets	microRNAs regulating expression of MPC1L gene predicted using nonconserved miRNA seed sequences from the TargetScan Predicted Nonconserved microRNA Targets dataset.
	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	tissues with high expression of MPC1L protein from the TISSUES Curated Tissue Protein Expression Evidence Scores 2025 dataset.
	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	tissues co-occuring with MPC1L protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 dataset.