{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nMROCKI, a long non‐coding RNA implicated in the regulation of cell survival, appears to modulate apoptosis in acute myeloid leukemia (AML) cells. Recent findings indicate that the expression of this RNA influences the activity of apoptotic pathways, thereby altering the balance between cell survival and programmed cell death. Its regulatory capacity seems to involve the modulation of key downstream targets that control apoptotic signaling, suggesting that elevated levels of MROCKI may contribute to the resistance of AML cells to apoptosis, an insight that potentially links it with the progression of the disease."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n\nFurther mechanistic exploration has revealed that manipulating MROCKI levels can impact the expression of apoptosis‐related genes, indicating its role as a critical node in the cellular network governing AML cell fate. These observations underscore the potential of MROCKI as a therapeutic target, where its inhibition might restore the apoptotic process in AML cells and thereby provide a novel avenue for treatment."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Wan Chen, Ding-Yun Gan "}, {"type": "b", "children": [{"type": "t", "text": "[Effect of Long Non-Coding RNA LINC01268 on the Malignant Biological Behaviors of Acute Myeloid Leukemia Cells]."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Zhongguo Shi Yan Xue Ye Xue Za Zhi (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.19746/j.cnki.issn.1009-2137.2023.06.002"}], "href": "https://doi.org/10.19746/j.cnki.issn.1009-2137.2023.06.002"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38071035"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38071035"}]}]}]}