MSI2 Gene

HGNC Family	RNA binding motif containing (RBM)
Name	musashi RNA-binding protein 2
Description	This gene encodes an RNA-binding protein that is a member of the Musashi protein family. The encoded protein is transcriptional regulator that targets genes involved in development and cell cycle regulation. Mutations in this gene are associated with poor prognosis in certain types of cancers. This gene has also been shown to be rearranged in certain cancer cells. [provided by RefSeq, Apr 2016]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nMusashi‐2 (MSI2) is a highly conserved RNA‐binding protein that plays a central role in post‐transcriptional gene regulation. By binding to specific mRNA targets, MSI2 modulates translation of factors controlling stem cell fate, differentiation, and cell proliferation. In several contexts it represses differentiation‐promoting proteins such as Numb, thereby contributing to the maintenance of an undifferentiated, proliferative cell state."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn hematologic malignancies—including chronic myelogenous leukemia (CML), acute myeloid leukemia (AML), and chronic lymphocytic leukemia (CLL)—MSI2 is frequently overexpressed. Elevated MSI2 enforces oncogenic translation programs that sustain leukemic stem cell self‐renewal by supporting the efficient translation of key oncogenes (e.g. HOXA9, MYC) and regulators such as FLT3. Loss or knockdown of MSI2 in leukemic cells leads to reduced clonogenic potential, cell cycle arrest, and apoptosis, underscoring its prognostic significance and therapeutic potential in these diseases."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}, {"type": "fg_fs", "start_ref": "3", "end_ref": "11"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nMSI2 dysregulation also plays a prominent oncogenic role in several solid tumors. In non–small cell lung cancer, for example, overexpression of MSI2 correlates with enhanced invasion through promotion of epithelial‐to‐mesenchymal transition (EMT) via activation of TGFβ/SMAD signaling. In colorectal, hepatocellular, and pancreatic cancers, elevated MSI2 levels drive tumorigenesis by affecting cell proliferation and by perturbing the expression of tumor suppressors through pathways such as the PDK–AKT–mTOR cascade. In addition, its aberrant activity has been linked to brain tumors and esophageal and gastric cancers, where MSI2‐mediated translational control contributes to an aggressive, invasive phenotype and predictive poor outcomes."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}, {"type": "fg_fs", "start_ref": "12", "end_ref": "21"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nUpstream regulatory mechanisms—including epigenetic modifications such as differential CpG methylation within the MSI2 locus—and contextual changes in MSI2’s RNA–binding network further refine its activity. These layers of regulation help explain the tissue‐ and disease–specific outcomes of MSI2 dysregulation, and they highlight its value not only as a prognostic biomarker but also as a potential target for therapeutic intervention."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "22"}, {"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nCollectively, the studies reviewed herein underscore MSI2’s multifaceted role in both hematologic and solid malignancies. By orchestrating the translation of critical regulators of cell proliferation, differentiation, and invasion, MSI2 promotes cancer progression and the maintenance of malignant stem cell populations. Its consistent association with poor clinical outcomes across diverse tumor types positions MSI2 as a promising biomarker and therapeutic target in oncology."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}, {"type": "fg_f", "ref": "18"}, {"type": "fg_f", "ref": "6"}, {"type": "fg_f", "ref": "20"}, {"type": "fg_f", "ref": "11"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Takahiro Ito, Hyog Young Kwon, Bryan Zimdahl, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Regulation of myeloid leukaemia by the cell-fate determinant Musashi."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nature (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nature09171"}], "href": "https://doi.org/10.1038/nature09171"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20639863"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20639863"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Alexander E Kudinov, John Karanicolas, Erica A Golemis, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Musashi RNA-Binding Proteins as Cancer Drivers and Novel Therapeutic Targets."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin Cancer Res (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/1078-0432.CCR-16-2728"}], "href": "https://doi.org/10.1158/1078-0432.CCR-16-2728"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28143872"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28143872"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Stefan Rentas, Nicholas Holzapfel, Muluken S Belew, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Musashi-2 attenuates AHR signalling to expand human haematopoietic stem cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nature (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nature17665"}], "href": "https://doi.org/10.1038/nature17665"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27121842"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27121842"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Richard J Byers, Treeve Currie, Eleni Tholouli, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MSI2 protein expression predicts unfavorable outcome in acute myeloid leukemia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Blood (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1182/blood-2011-04-346767"}], "href": "https://doi.org/10.1182/blood-2011-04-346767"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21753187"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21753187"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Sun-Mi Park, Mithat Gönen, Ly Vu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Musashi2 sustains the mixed-lineage leukemia-driven stem cell regulatory program."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Invest (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1172/JCI78440"}], "href": "https://doi.org/10.1172/JCI78440"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25664853"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25664853"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Diu T T Nguyen, Yuheng Lu, Eren L Chu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "HyperTRIBE uncovers increased MUSASHI-2 RNA binding activity and differential regulation in leukemic stem cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41467-020-15814-8"}], "href": "https://doi.org/10.1038/s41467-020-15814-8"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32332729"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32332729"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Huijuan Zhang, Shi Tan, Juan Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Musashi2 modulates K562 leukemic cell proliferation and apoptosis involving the MAPK pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Exp Cell Res (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.yexcr.2013.09.009"}], "href": "https://doi.org/10.1016/j.yexcr.2013.09.009"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24076374"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24076374"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "An De Weer, Frank Speleman, Barbara Cauwelier, et al. "}, {"type": "b", "children": [{"type": "t", "text": "EVI1 overexpression in t(3;17) positive myeloid malignancies results from juxtaposition of EVI1 to the MSI2 locus at 17q22."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Haematologica (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3324/haematol.13192"}], "href": "https://doi.org/10.3324/haematol.13192"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18815193"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18815193"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Florencia Palacios, Xiao-Jie Yan, Gerardo Ferrer, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Musashi 2 influences chronic lymphocytic leukemia cell survival and growth making it a potential therapeutic target."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Leukemia (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41375-020-01115-y"}], "href": "https://doi.org/10.1038/s41375-020-01115-y"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33504942"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33504942"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Jaspal Kaeda, Frauke Ringel, Christian Oberender, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Up-regulated MSI2 is associated with more aggressive chronic myeloid leukemia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Leuk Lymphoma (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3109/10428194.2014.981175"}], "href": "https://doi.org/10.3109/10428194.2014.981175"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25363400"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25363400"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Ayuna Hattori, Daniel McSkimming, Natarajan Kannan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "RNA binding protein MSI2 positively regulates FLT3 expression in myeloid leukemia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Leuk Res (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.leukres.2017.01.015"}], "href": "https://doi.org/10.1016/j.leukres.2017.01.015"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28107692"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28107692"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Alexander E Kudinov, Alexander Deneka, Anna S Nikonova, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Musashi-2 (MSI2) supports TGF-β signaling and inhibits claudins to promote non-small cell lung cancer (NSCLC) metastasis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.1513616113"}], "href": "https://doi.org/10.1073/pnas.1513616113"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27274057"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27274057"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Shan Wang, Ning Li, Maryam Yousefi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Transformation of the intestinal epithelium by the MSI2 RNA-binding protein."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ncomms7517"}], "href": "https://doi.org/10.1038/ncomms7517"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25774828"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25774828"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Jesse L Cox, Phillip J Wilder, Joshua M Gilmore, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The SOX2-interactome in brain cancer cells identifies the requirement of MSI2 and USP9X for the growth of brain tumor cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0062857"}], "href": "https://doi.org/10.1371/journal.pone.0062857"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23667531"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23667531"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Lu He, Xinke Zhou, Chen Qu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Musashi2 predicts poor prognosis and invasion in hepatocellular carcinoma by driving epithelial-mesenchymal transition."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Mol Med (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/jcmm.12158"}], "href": "https://doi.org/10.1111/jcmm.12158"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24305552"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24305552"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Ly P Vu, Camila Prieto, Elianna M Amin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Functional screen of MSI2 interactors identifies an essential role for SYNCRIP in myeloid leukemia stem cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Genet (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ng.3854"}], "href": "https://doi.org/10.1038/ng.3854"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28436985"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28436985"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Ning Li, Maryam Yousefi, Angela Nakauka-Ddamba, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The Msi Family of RNA-Binding Proteins Function Redundantly as Intestinal Oncoproteins."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Rep (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.celrep.2015.11.022"}], "href": "https://doi.org/10.1016/j.celrep.2015.11.022"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26673327"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26673327"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Yarden Katz, Feifei Li, Nicole J Lambert, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Musashi proteins are post-transcriptional regulators of the epithelial-luminal cell state."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Elife (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.7554/eLife.03915"}], "href": "https://doi.org/10.7554/eLife.03915"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25380226"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25380226"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Kun Guo, Jiujie Cui, Ming Quan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The Novel KLF4/MSI2 Signaling Pathway Regulates Growth and Metastasis of Pancreatic Cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin Cancer Res (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/1078-0432.CCR-16-1064"}], "href": "https://doi.org/10.1158/1078-0432.CCR-16-1064"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27449499"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27449499"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Zhiwei Li, Hui Jin, Guozhang Mao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Msi2 plays a carcinogenic role in esophageal squamous cell carcinoma via regulation of the Wnt/β-catenin and Hedgehog signaling pathways."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Exp Cell Res (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.yexcr.2017.10.016"}], "href": "https://doi.org/10.1016/j.yexcr.2017.10.016"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29054489"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29054489"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "Modjtaba Emadi-Baygi, Parvaneh Nikpour, Faezeh Mohammad-Hashem, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MSI2 expression is decreased in grade II of gastric carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Pathol Res Pract (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.prp.2013.07.008"}], "href": "https://doi.org/10.1016/j.prp.2013.07.008"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24002004"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24002004"}]}, {"type": "r", "ref": 22, "children": [{"type": "t", "text": "Klodian Dhana, Kim V E Braun, Jana Nano, et al. "}, {"type": "b", "children": [{"type": "t", "text": "An Epigenome-Wide Association Study of Obesity-Related Traits."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Epidemiol (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/aje/kwy025"}], "href": "https://doi.org/10.1093/aje/kwy025"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29762635"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29762635"}]}]}]}
Synonyms	MSI2H
Proteins	MSI2H_HUMAN
NCBI Gene ID	124540
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

MSI2 has 10,900 functional associations with biological entities spanning 8 categories (molecular profile, organism, functional term, phrase or reference, chemical, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 122 datasets.

Click the + buttons to view associations for MSI2 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

MSI2 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of MSI2 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of MSI2 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of MSI2 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of MSI2 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of MSI2 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of MSI2 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of MSI2 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of MSI2 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of MSI2 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Gene Mutation Profiles	cell lines with MSI2 gene mutations from the CCLE Cell Line Gene Mutation Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with MSI2 protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with MSI2 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of MSI2 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of MSI2 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of MSI2 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	gene perturbations changing expression of MSI2 gene from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas dataset.
	CM4AI U2OS Cell Map Protein Localization Assemblies	assemblies containing MSI2 protein from integrated AP-MS and IF data from the CM4AI U2OS Cell Map Protein Localization Assemblies dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing MSI2 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing MSI2 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores	cellular components containing MSI2 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with MSI2 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with MSI2 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of MSI2 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with MSI2 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with MSI2 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with MSI2 gene/protein from the curated CTD Gene-Disease Associations dataset.
	dbGAP Gene-Trait Associations	traits associated with MSI2 gene in GWAS and other genetic association datasets from the dbGAP Gene-Trait Associations dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by MSI2 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with MSI2 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with MSI2 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with MSI2 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with MSI2 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with MSI2 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at MSI2 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of MSI2 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of MSI2 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing MSI2 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GAD Gene-Disease Associations	diseases associated with MSI2 gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.
	GAD High Level Gene-Disease Associations	diseases associated with MSI2 gene in GWAS and other genetic association datasets from the GAD High Level Gene-Disease Associations dataset.
	GeneRIF Biological Term Annotations	biological terms co-occuring with MSI2 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.