MT1HL1 Gene

HGNC Family	Metallothioneins (MT)
Name	metallothionein 1H-like 1
Description	This gene is a retrotransposed gene, compared to MT1H (GeneID:4496). This retrogene is transcribed. It retains a full-length CDS, and is assumed to be translated. Compared to the MT1H product, this protein product differs at three internal amino acids, two of which are at metal-binding sites. [provided by RefSeq, Mar 2013]
Synonyms	MT1P2
Proteins	M1BL1_HUMAN
NCBI Gene ID	645745
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Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

MT1HL1 has 3,080 functional associations with biological entities spanning 6 categories (chemical, disease, phenotype or trait, functional term, phrase or reference, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 25 datasets.

Click the + buttons to view associations for MT1HL1 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

MT1HL1 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of MT1HL1 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of MT1HL1 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with MT1HL1 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of MT1HL1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of MT1HL1 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of MT1HL1 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	CTD Gene-Disease Associations	diseases associated with MT1HL1 gene/protein from the curated CTD Gene-Disease Associations dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by MT1HL1 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	GeneSigDB Published Gene Signatures	PubMedIDs of publications reporting gene signatures containing MT1HL1 from the GeneSigDB Published Gene Signatures dataset.
	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	gene perturbations changing expression of MT1HL1 gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset.
	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	kinase perturbations changing expression of MT1HL1 gene from the GEO Signatures of Differentially Expressed Genes for Kinase Perturbations dataset.
	GEO Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of MT1HL1 gene from the GEO Signatures of Differentially Expressed Genes for Small Molecules dataset.
	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	transcription factor perturbations changing expression of MT1HL1 gene from the GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations dataset.
	GO Biological Process Annotations 2023	biological processes involving MT1HL1 gene from the curated GO Biological Process Annotations 2023 dataset.
	GO Molecular Function Annotations 2015	molecular functions performed by MT1HL1 gene from the curated GO Molecular Function Annotations 2015 dataset.
	GTEx Tissue Gene Expression Profiles	tissues with high or low expression of MT1HL1 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles dataset.
	GTEx Tissue Gene Expression Profiles 2023	tissues with high or low expression of MT1HL1 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles 2023 dataset.
	InterPro Predicted Protein Domain Annotations	protein domains predicted for MT1HL1 protein from the InterPro Predicted Protein Domain Annotations dataset.
	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	small molecule perturbations changing expression of MT1HL1 gene from the LINCS L1000 CMAP Chemical Perturbations Consensus Signatures dataset.
	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	gene perturbations changing expression of MT1HL1 gene from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset.
	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of MT1HL1 gene from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	LOCATE Predicted Protein Localization Annotations	cellular components predicted to contain MT1HL1 protein from the LOCATE Predicted Protein Localization Annotations dataset.
	MiRTarBase microRNA Targets	microRNAs targeting MT1HL1 gene in low- or high-throughput microRNA targeting studies from the MiRTarBase microRNA Targets dataset.
	MotifMap Predicted Transcription Factor Targets	transcription factors regulating expression of MT1HL1 gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset.
	Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles	cell types and tissues with high or low DNA methylation of MT1HL1 gene relative to other cell types and tissues from the Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles dataset.