MTCH2 Gene

HGNC Family	Solute carriers (SLC)
Name	mitochondrial carrier 2
Description	This gene encodes a member of the SLC25 family of nuclear-encoded transporters that are localized in the inner mitochondrial membrane. Members of this superfamily are involved in many metabolic pathways and cell functions. Genome-wide association studies in human have identified single-nucleotide polymorphisms in several loci associated with obesity. This gene is one such locus, which is highly expressed in white adipose tissue and adipocytes, and thought to play a regulatory role in adipocyte differentiation and biology. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. A recent study showed this gene to be an authentic stop codon readthrough target that can produce two isoforms from the same mRNA by use of alternative in-frame translation termination codons. [provided by RefSeq, Dec 2017]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nMTCH2 has emerged as one of several genes implicated in the regulation of body mass and energy homeostasis. Genome‐wide association studies have repeatedly linked genetic variants near MTCH2 with differences in body mass index and adiposity, with expression patterns in the central nervous system underpinning its role in energy balance and obesity predisposition ["}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "7"}]}, {"type": "t", "text": "].\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its metabolic associations, MTCH2 plays a central role in the apoptotic pathway. As an integral protein of the mitochondrial outer membrane, it acts as a receptor for truncated BID (tBID), thereby facilitating the recruitment and activation of proapoptotic effectors such as BAX. This interaction is critical for mitochondrial outer membrane permeabilization and the progression of apoptosis, and modulating the MTCH2–tBID interface presents a potential target for anticancer therapies ["}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "8", "end_ref": "11"}]}, {"type": "t", "text": "].\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nMTCH2 also orchestrates key aspects of mitochondrial dynamics and metabolic regulation. It modulates mitochondrial fusion in response to cellular nutrient status—acting through intermediates such as lysophosphatidic acid to promote mitochondrial elongation under starvation conditions. Moreover, alternative translational read‐through events generate MTCH2 isoforms with distinct C termini and subcellular localizations, thereby fine‐tuning mitochondrial membrane potential and overall bioenergetics. In pathological contexts, altered MTCH2 expression disrupts normal mitochondrial function: in acute myeloid leukemia, reduced MTCH2 impairs cell growth and fosters differentiation via effects on pyruvate metabolism and histone acetylation, while in glioma, its dysregulation contributes to a metabolic shift favoring tumor progression. In conditions such as cardiomyopathy, lower MTCH2 levels are associated with impaired glucose oxidation and an increased reliance on fatty acids, underscoring its role in substrate selection and energy metabolism. Additionally, studies have shown that MTCH2 regulation by agents like dihydroartemisinin further ties its expression to the induction of p53 and apoptosis, and reviews highlight its multifaceted functions spanning apoptotic control, metabolic homeostasis, and mitochondrial dynamics ["}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "12", "end_ref": "20"}]}, {"type": "t", "text": "].\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn addition to its roles in metabolism and apoptosis, MTCH2 participates in host–pathogen interactions; for instance, it has been shown to interact with the PA subunit of the influenza A virus polymerase, highlighting a potential role in antiviral responses. Collectively, these findings characterize MTCH2 as a multifaceted mitochondrial outer membrane protein that integrates apoptotic signals, metabolic cues, and mitochondrial dynamics to impact a range of conditions—from obesity and cancer to cardiometabolic disorders and viral infections ["}, {"type": "fg", "children": [{"type": "fg_f", "ref": "21"}]}, {"type": "t", "text": "].\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Cristen J Willer, Elizabeth K Speliotes, Ruth J F Loos, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Six new loci associated with body mass index highlight a neuronal influence on body weight regulation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Genet (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ng.287"}], "href": "https://doi.org/10.1038/ng.287"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19079261"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19079261"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Frida Renström, Felicity Payne, Anna Nordström, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Replication and extension of genome-wide association study results for obesity in 4923 adults from northern Sweden."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Mol Genet (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/hmg/ddp041"}], "href": "https://doi.org/10.1093/hmg/ddp041"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19164386"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19164386"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Florianne Bauer, Clara C Elbers, Roger Ah Adan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Obesity genes identified in genome-wide association studies are associated with adiposity measures and potentially with nutrient-specific food preference."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Clin Nutr (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3945/ajcn.2009.27781"}], "href": "https://doi.org/10.3945/ajcn.2009.27781"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19692490"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19692490"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Shengxu Li, Jing Hua Zhao, Jian'an Luan, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Association between obesity and polymorphisms in SEC16B, TMEM18, GNPDA2, BDNF, FAIM2 and MC4R in a Japanese population."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Hum Genet (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/jhg.2009.106"}], "href": "https://doi.org/10.1038/jhg.2009.106"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19851340"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19851340"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Maggie C Y Ng, Claudia H T Tam, Wing Yee So, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Implication of genetic variants near NEGR1, SEC16B, TMEM18, ETV5/DGKG, GNPDA2, LIN7C/BDNF, MTCH2, BCDIN3D/FAIM2, SH2B1, FTO, MC4R, and KCTD15 with obesity and type 2 diabetes in 7705 Chinese."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Endocrinol Metab (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1210/jc.2009-2077"}], "href": "https://doi.org/10.1210/jc.2009-2077"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20215397"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20215397"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Agné Kulyté, Mikael Rydén, Niklas Mejhert, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MTCH2 in human white adipose tissue and obesity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Endocrinol Metab (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1210/jc.2010-3050"}], "href": "https://doi.org/10.1210/jc.2010-3050"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21795451"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21795451"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Michal Grinberg, Michal Schwarz, Yehudit Zaltsman, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Mitochondrial carrier homolog 2 is a target of tBID in cells signaled to die by tumor necrosis factor alpha."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biol (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/MCB.25.11.4579-4590.2005"}], "href": "https://doi.org/10.1128/MCB.25.11.4579-4590.2005"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15899861"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15899861"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Chen Katz, Yehudit Zaltsman-Amir, Yana Mostizky, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Molecular basis of the interaction between proapoptotic truncated BID (tBID) protein and mitochondrial carrier homologue 2 (MTCH2) protein: key players in mitochondrial death pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M111.328377"}], "href": "https://doi.org/10.1074/jbc.M111.328377"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22416135"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22416135"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "E Raemy, S Montessuit, S Pierredon, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Cardiolipin or MTCH2 can serve as tBID receptors during apoptosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Death Differ (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/cdd.2015.166"}], "href": "https://doi.org/10.1038/cdd.2015.166"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26794447"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26794447"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Atan Gross "}, {"type": "b", "children": [{"type": "t", "text": "BCL-2 family proteins as regulators of mitochondria metabolism."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochim Biophys Acta (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbabio.2016.01.017"}], "href": "https://doi.org/10.1016/j.bbabio.2016.01.017"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26827940"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26827940"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Ting Zhang, Yuan Hu, Ting Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Dihydroartemisinin inhibits the viability of cervical cancer cells by upregulating caveolin 1 and mitochondrial carrier homolog 2: Involvement of p53 activation and NAD(P)H:quinone oxidoreductase 1 downregulation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Mol Med (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/ijmm.2017.2980"}], "href": "https://doi.org/10.3892/ijmm.2017.2980"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28498397"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28498397"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Tirta Mario Djajawi, Lei Liu, Jia-Nan Gong, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MARCH5 requires MTCH2 to coordinate proteasomal turnover of the MCL1:NOXA complex."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Death Differ (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41418-020-0517-0"}], "href": "https://doi.org/10.1038/s41418-020-0517-0"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32094511"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32094511"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Dilshad H Khan, Michael Mullokandov, Yan Wu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Mitochondrial carrier homolog 2 is necessary for AML survival."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Blood (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1182/blood.2019000106"}], "href": "https://doi.org/10.1182/blood.2019000106"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32299104"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32299104"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Lekha E Manjunath, Anumeha Singh, Sarthak Sahoo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Stop codon read-through of mammalian "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "MTCH2"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": " leading to an unstable isoform regulates mitochondrial membrane potential."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.RA120.014253"}], "href": "https://doi.org/10.1074/jbc.RA120.014253"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33028634"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33028634"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Qiuyun Yuan, Wanchun Yang, Shuxin Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Inhibition of mitochondrial carrier homolog 2 (MTCH2) suppresses tumor invasion and enhances sensitivity to temozolomide in malignant glioma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Med (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s10020-020-00261-4"}], "href": "https://doi.org/10.1186/s10020-020-00261-4"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33509092"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33509092"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Katherine Labbé, Shona Mookerjee, Maxence Le Vasseur, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The modified mitochondrial outer membrane carrier MTCH2 links mitochondrial fusion to lipogenesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biol (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1083/jcb.202103122"}], "href": "https://doi.org/10.1083/jcb.202103122"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34586346"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34586346"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Julie A Fischer, Tanner O Monroe, Lorenzo L Pesce, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Opposing effects of genetic variation in MTCH2 for obesity versus heart failure."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Mol Genet (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/hmg/ddac176"}], "href": "https://doi.org/10.1093/hmg/ddac176"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35904451"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35904451"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Andres Goldman, Michael Mullokandov, Yehudit Zaltsman, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MTCH2 cooperates with MFN2 and lysophosphatidic acid synthesis to sustain mitochondrial fusion."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "EMBO Rep (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s44319-023-00009-1"}], "href": "https://doi.org/10.1038/s44319-023-00009-1"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38177900"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38177900"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Xiaohe Zheng, Binxiang Chu "}, {"type": "b", "children": [{"type": "t", "text": "The biology of mitochondrial carrier homolog 2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mitochondrion (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.mito.2023.101837"}], "href": "https://doi.org/10.1016/j.mito.2023.101837"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38158152"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38158152"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "Pınar Ulupinar, Elif Çağlayan, Erkan Rayaman, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The mitochondrial carrier homolog 2 is involved in down-regulation of influenza A virus replication."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Biol Rep (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s11033-024-09584-5"}], "href": "https://doi.org/10.1007/s11033-024-09584-5"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38727866"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38727866"}]}]}]}
Synonyms	HSPC032, SLC25A50, MIMP
Proteins	MTCH2_HUMAN
NCBI Gene ID	23788
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

MTCH2 has 7,265 functional associations with biological entities spanning 9 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 124 datasets.

Click the + buttons to view associations for MTCH2 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

MTCH2 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Achilles Cell Line Gene Essentiality Profiles	cell lines with fitness changed by MTCH2 gene knockdown relative to other cell lines from the Achilles Cell Line Gene Essentiality Profiles dataset.
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of MTCH2 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of MTCH2 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of MTCH2 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of MTCH2 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of MTCH2 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of MTCH2 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of MTCH2 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of MTCH2 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of MTCH2 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of MTCH2 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of MTCH2 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of MTCH2 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with MTCH2 protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with MTCH2 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of MTCH2 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of MTCH2 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of MTCH2 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CM4AI U2OS Cell Map Protein Localization Assemblies	assemblies containing MTCH2 protein from integrated AP-MS and IF data from the CM4AI U2OS Cell Map Protein Localization Assemblies dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of MTCH2 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing MTCH2 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing MTCH2 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores	cellular components containing MTCH2 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	cellular components containing MTCH2 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with MTCH2 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with MTCH2 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of MTCH2 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with MTCH2 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with MTCH2 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with MTCH2 gene/protein from the curated CTD Gene-Disease Associations dataset.
	dbGAP Gene-Trait Associations	traits associated with MTCH2 gene in GWAS and other genetic association datasets from the dbGAP Gene-Trait Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of MTCH2 protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by MTCH2 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores	diseases associated with MTCH2 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with MTCH2 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with MTCH2 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with MTCH2 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with MTCH2 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with MTCH2 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at MTCH2 gene from the ENCODE Histone Modification Site Profiles dataset.