{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nResearch in mouse and human adipocytes has revealed that MTLN—a peptide encoded within the conserved region of the lncRNA LINC00116—plays a critical role in regulating adipocyte metabolism. Specifically, MTLN modulates triglyceride clearance by enhancing lipolysis and mitochondrial β‑oxidation, and it exerts these effects through a direct interaction with the β subunit of the mitochondrial trifunctional protein, an enzyme essential for processing long‑chain fatty acids. This functional link is supported by systemic lipid phenotypes in knockout mice as well as adipocyte‑autonomous effects observed in both murine isolated cells and human stem cell‑derived adipocytes, highlighting the therapeutic potential of targeting MTLN in metabolic disorders."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn addition to its metabolic role, the transcript designated as LINC00116 has also been implicated in tumorigenesis, particularly in cervical cancer. Here, downregulation of LINC00116 attenuates proliferation, invasion, and migration of cervical cancer cells. Mechanistic studies reveal that LINC00116 modulates the miR‑106a/c‑Jun axis, thereby influencing the expression of critical oncogenic and immune regulatory factors such as programmed cell death ligand 1 (PD‑L1). These findings suggest that, beyond encoding MTLN, the LINC00116 transcript itself may contribute to cancer progression by regulating key molecular pathways associated with tumorigenicity."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nComplementing these discoveries, recent work on another long non‑coding RNA, TP53‑inhibiting lncRNA (TILR), in lung cancer provides insight into the diverse regulatory roles of non‑coding RNAs in cellular metabolism and stress responses. TILR acts as a constitutive negative regulator of the tumor suppressor p53 by binding both PCBP2 and p53 mRNA, thereby modulating downstream gene expression and apoptosis. Although TILR operates through mechanisms distinct from those of LINC00116/MTLN, its study underscores the broader significance of non‑coding RNAs in critical cellular processes and highlights the complex interplay between RNA‑based regulation and cellular metabolism."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Max Friesen, Curtis R Warren, Haojie Yu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Mitoregulin Controls β-Oxidation in Human and Mouse Adipocytes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Stem Cell Reports (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.stemcr.2020.03.002"}], "href": "https://doi.org/10.1016/j.stemcr.2020.03.002"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32243843"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32243843"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Yiqing Lai, Beibei Zhou, Qingqing Tan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LINC00116 enhances cervical cancer tumorigenesis through miR-106a/c-Jun pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biochem (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcb.29447"}], "href": "https://doi.org/10.1002/jcb.29447"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31693227"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31693227"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Mika Iwai, Taisuke Kajino, Masahiro Nakatochi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long non-coding RNA TILR constitutively represses TP53 and apoptosis in lung cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41388-022-02546-w"}], "href": "https://doi.org/10.1038/s41388-022-02546-w"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36522487"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36522487"}]}]}]}