MX2 Gene

Name	MX dynamin-like GTPase 2
Description	The protein encoded by this gene has a nuclear and a cytoplasmic form and is a member of both the dynamin family and the family of large GTPases. The nuclear form is localized in a granular pattern in the heterochromatin region beneath the nuclear envelope. A nuclear localization signal (NLS) is present at the amino terminal end of the nuclear form but is lacking in the cytoplasmic form due to use of an alternate translation start codon. This protein is upregulated by interferon-alpha but does not contain the antiviral activity of a similar myxovirus resistance protein 1. [provided by RefSeq, Jul 2008]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nHuman MX2 (also known as MXB) is an interferon‐induced, dynamin‐like GTPase that potently restricts HIV‐1 infection by acting after reverse transcription yet before nuclear import and integration of the viral cDNA. MX2 exerts its anti‐HIV activity primarily through binding to the viral capsid, with its N‐terminal domain playing an essential role in recognizing capsid determinants, in some cases in a cyclophilin A–dependent manner, and in orchestrating interactions with components of the nuclear pore complex. Moreover, minimal oligomerization requirements and proper localization at the nuclear envelope enable MX2 to inhibit the nuclear trafficking of viral genomes, while mutations in the capsid can render HIV-1 resistant to MX2 restriction."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "12"}]}, {"type": "t", "text": "\n \nIn addition to its well‐documented anti‐HIV properties, MX2 displays a broader antiviral spectrum. It restricts several herpesviruses by interfering with early events such as the uncoating process and nuclear delivery of viral genomes—a mechanism that, in contrast to HIV-1 inhibition, requires intact GTPase function. MX2 has also been implicated in reducing hepatitis B virus replication, although it does not inhibit all retroviruses (for example, foamy viruses are resistant). Furthermore, its antiviral efficacy can be modulated by post-translational modifications (such as phosphorylation regulated by myosin light chain phosphatase) and by interactions with other restriction factors like SAMHD1, with cell-type and viral envelope determinants (as shown by differences observed with vesicular stomatitis virus G protein-pseudotyped HIV-1) influencing the overall antiviral state."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "13", "end_ref": "21"}]}, {"type": "t", "text": "\n \nEvolutionary and functional studies reveal that MX2 has been shaped by positive selection in primates, resulting in sequence diversification—particularly in its variable N-terminal region—that tunes its antiviral specificity. Beyond its role as a viral restriction factor, MX2 may also have cell type–specific functions, as indicated by emerging evidence of its involvement in modulating intracellular signaling in glioma cells. Together, these findings establish MX2 as a multifaceted effector of the innate immune response whose activity is dictated by its structural features, interaction with cellular cofactors, and post-translational control mechanisms."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "22"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Caroline Goujon, Olivier Moncorgé, Hélène Bauby, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Human MX2 is an interferon-induced post-entry inhibitor of HIV-1 infection."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nature (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nature12542"}], "href": "https://doi.org/10.1038/nature12542"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24048477"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24048477"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Zhenlong Liu, Qinghua Pan, Shilei Ding, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The interferon-inducible MxB protein inhibits HIV-1 infection."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Host Microbe (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.chom.2013.08.015"}], "href": "https://doi.org/10.1016/j.chom.2013.08.015"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24055605"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24055605"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Melissa Kane, Shalini S Yadav, Julia Bitzegeio, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MX2 is an interferon-induced inhibitor of HIV-1 infection."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nature (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nature12653"}], "href": "https://doi.org/10.1038/nature12653"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24121441"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24121441"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Idoia Busnadiego, Melissa Kane, Suzannah J Rihn, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Host and viral determinants of Mx2 antiretroviral activity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Virol (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/JVI.00214-14"}], "href": "https://doi.org/10.1128/JVI.00214-14"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24760893"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24760893"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Thomas Fricke, Tommy E White, Bianca Schulte, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MxB binds to the HIV-1 core and prevents the uncoating process of HIV-1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Retrovirology (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12977-014-0068-x"}], "href": "https://doi.org/10.1186/s12977-014-0068-x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25123063"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25123063"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Kenneth A Matreyek, Weifeng Wang, Erik Serrao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Host and viral determinants for MxB restriction of HIV-1 infection."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Retrovirology (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12977-014-0090-z"}], "href": "https://doi.org/10.1186/s12977-014-0090-z"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25348155"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25348155"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Zhenlong Liu, Qinghua Pan, Zhibin Liang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The highly polymorphic cyclophilin A-binding loop in HIV-1 capsid modulates viral resistance to MxB."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Retrovirology (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12977-014-0129-1"}], "href": "https://doi.org/10.1186/s12977-014-0129-1"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25571928"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25571928"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Caroline Goujon, Rebecca A Greenbury, Stelios Papaioannou, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A triple-arginine motif in the amino-terminal domain and oligomerization are required for HIV-1 inhibition by human MX2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Virol (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/JVI.00169-15"}], "href": "https://doi.org/10.1128/JVI.00169-15"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25673704"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25673704"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Silvana Opp, Daniel A S A Vieira, Bianca Schulte, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MxB Is Not Responsible for the Blocking of HIV-1 Infection Observed in Alpha Interferon-Treated Cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Virol (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/JVI.03146-15"}], "href": "https://doi.org/10.1128/JVI.03146-15"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26719253"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26719253"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Melissa Kane, Stephanie V Rebensburg, Matthew A Takata, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Nuclear pore heterogeneity influences HIV-1 infection and the antiviral activity of MX2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Elife (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.7554/eLife.35738"}], "href": "https://doi.org/10.7554/eLife.35738"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30084827"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30084827"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Sarah Sierra Smaga, Chaoyi Xu, Brady James Summers, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MxB Restricts HIV-1 by Targeting the Tri-hexamer Interface of the Viral Capsid."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Structure (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.str.2019.04.015"}], "href": "https://doi.org/10.1016/j.str.2019.04.015"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31155311"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31155311"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Linlin Xie, Lang Chen, Chaojie Zhong, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MxB impedes the NUP358-mediated HIV-1 pre-integration complex nuclear import and viral replication cooperatively with CPSF6."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Retrovirology (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12977-020-00524-2"}], "href": "https://doi.org/10.1186/s12977-020-00524-2"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32600399"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32600399"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Ariane Bähr, Anna Singer, Anika Hain, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Interferon but not MxB inhibits foamy retroviruses."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Virology (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.virol.2015.10.034"}], "href": "https://doi.org/10.1016/j.virol.2015.10.034"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26609934"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26609934"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Michel Crameri, Michael Bauer, Nicole Caduff, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MxB is an interferon-induced restriction factor of human herpesviruses."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41467-018-04379-2"}], "href": "https://doi.org/10.1038/s41467-018-04379-2"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29773792"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29773792"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Bin Xu, Qinghua Pan, Chen Liang "}, {"type": "b", "children": [{"type": "t", "text": "Role of MxB in Alpha Interferon-Mediated Inhibition of HIV-1 Infection."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Virol (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/JVI.00422-18"}], "href": "https://doi.org/10.1128/JVI.00422-18"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29925663"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29925663"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Mirjam Schilling, Lorenzo Bulli, Sebastian Weigang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Human MxB Protein Is a Pan-herpesvirus Restriction Factor."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Virol (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/JVI.01056-18"}], "href": "https://doi.org/10.1128/JVI.01056-18"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29950411"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29950411"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Ananda Ayyappan Jaguva Vasudevan, Ariane Bähr, Ramona Grothmann, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MXB inhibits murine cytomegalovirus."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Virology (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.virol.2018.07.017"}], "href": "https://doi.org/10.1016/j.virol.2018.07.017"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30032029"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30032029"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Yong-Xiang Wang, Matthias Niklasch, Tiantian Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Interferon-inducible MX2 is a host restriction factor of hepatitis B virus replication."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Hepatol (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.jhep.2019.12.009"}], "href": "https://doi.org/10.1016/j.jhep.2019.12.009"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31863794"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31863794"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Cindy Buffone, Juliane Kutzner, Silvana Opp, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The ability of SAMHD1 to block HIV-1 but not SIV requires expression of MxB."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Virology (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.virol.2019.03.018"}], "href": "https://doi.org/10.1016/j.virol.2019.03.018"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30959264"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30959264"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Richard J Miles, Claire Kerridge, Laura Hilditch, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MxB sensitivity of HIV-1 is determined by a highly variable and dynamic capsid surface."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Elife (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.7554/eLife.56910"}], "href": "https://doi.org/10.7554/eLife.56910"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32553106"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32553106"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "Gilberto Betancor, Jose M Jimenez-Guardeño, Steven Lynham, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MX2-mediated innate immunity against HIV-1 is regulated by serine phosphorylation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Microbiol (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41564-021-00937-5"}], "href": "https://doi.org/10.1038/s41564-021-00937-5"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34282309"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34282309"}]}, {"type": "r", "ref": 22, "children": [{"type": "t", "text": "Huanyu Wang, Qiang Guan, Yang Nan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Overexpression of human MX2 gene suppresses cell proliferation, migration, and invasion via ERK/P38/NF-κB pathway in glioblastoma cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biochem (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcb.29189"}], "href": "https://doi.org/10.1002/jcb.29189"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31265172"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31265172"}]}, {"type": "r", "ref": 23, "children": [{"type": "t", "text": "Jiyeon Choi, Tongwu Zhang, Andrew Vu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Massively parallel reporter assays of melanoma risk variants identify MX2 as a gene promoting melanoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41467-020-16590-1"}], "href": "https://doi.org/10.1038/s41467-020-16590-1"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32483191"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32483191"}]}]}]}
Synonyms	MXB
Proteins	MX2_HUMAN
NCBI Gene ID	4600
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

MX2 has 9,521 functional associations with biological entities spanning 9 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 120 datasets.

Click the + buttons to view associations for MX2 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

MX2 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of MX2 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of MX2 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of MX2 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of MX2 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of MX2 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of MX2 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of MX2 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of MX2 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of MX2 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of MX2 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of MX2 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with MX2 protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with MX2 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of MX2 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of MX2 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of MX2 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	gene perturbations changing expression of MX2 gene from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of MX2 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing MX2 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing MX2 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with MX2 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with MX2 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of MX2 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with MX2 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with MX2 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with MX2 gene/protein from the curated CTD Gene-Disease Associations dataset.
	dbGAP Gene-Trait Associations	traits associated with MX2 gene in GWAS and other genetic association datasets from the dbGAP Gene-Trait Associations dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by MX2 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Curated Gene-Disease Association Evidence Scores 2025	diseases involving MX2 gene from the DISEASES Curated Gene-Disease Association Evidence Scores 2025 dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores	diseases associated with MX2 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with MX2 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with MX2 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with MX2 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with MX2 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with MX2 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at MX2 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of MX2 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of MX2 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing MX2 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GAD Gene-Disease Associations	diseases associated with MX2 gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.