{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nMYCNUT is a long non-coding RNA originating from a genomic region that encompasses the MYCN oncogene, a locus critically implicated in neuroblastoma. In patients with neuroblastoma, amplification of a 130‐kb region containing MYCN is associated with poor prognosis, suggesting that transcripts from this region—including MYCNUT—may contribute to the deregulated expression of MYCN and promote tumor aggressiveness."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n \nInterrogation of MYCNUT’s functional role has recently extended to breast cancer. In this context, the lncRNA lncUSMycN—functionally analogous to MYCNUT—has been evaluated in tumor samples and breast cancer cell lines. The investigation suggests that this transcript may participate in oncogenic regulatory networks, potentially modulating cell proliferation or survival pathways that contribute to breast cancer pathogenesis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n \nCollectively, these studies underscore the oncogenic potential of MYCNUT, whether by fostering MYCN overexpression in neuroblastoma or by its emerging role in tumorigenesis in breast cancer. Such observations advocate for further mechanistic studies on MYCNUT/lncUSMycN as both a biomarker and a prospective therapeutic target in diverse malignancies."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Pei Y Liu, Daniela Erriquez, Glenn M Marshall, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Effects of a novel long noncoding RNA, lncUSMycN, on N-Myc expression and neuroblastoma progression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Natl Cancer Inst (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/jnci/dju113"}], "href": "https://doi.org/10.1093/jnci/dju113"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24906397"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24906397"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Reyhaneh Ravanbakhsh Gavgani, Esmaeil Babaei, Mohammad Ali Hosseinpourfeizi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Clinical and in vitro Study of Novel Long Non-Coding RNA lncUSMycN in Breast Cancer"}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Iran Biomed J (2019)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31102367"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31102367"}]}]}]}