{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nMYCT1, originally identified as a direct target of c‐Myc and emerging as a candidate tumor suppressor gene, has been widely implicated in several malignancies. In laryngeal and gastric cancers, decreased MYCT1 expression is linked to enhanced cell proliferation and migration and diminished apoptosis. In these contexts, MYCT1 is repressed by transcription factors such as YY1 and modulated by microRNAs – for example, through the SP1/miR-629-3p/ESRP2 pathway in laryngeal cancer and via MAX/miR-181a/NPM1 signaling – underscoring its role in restraining tumor growth and aggressiveness. Furthermore, its downregulation is associated with poor clinical parameters not only in laryngeal squamous cell carcinoma but also in lymphoma, highlighting its tumor-suppressive potential."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "8"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn addition to its role in cancer cell behavior, MYCT1 is critical in regulating the tumor microenvironment. In endothelial cells, where it is almost exclusively expressed, MYCT1 modulates tumor angiogenesis by interacting with tight junction proteins such as Zona Occludens 1 and regulating Rho GTPase-mediated actin cytoskeleton dynamics. Such regulation enhances endothelial motility and vessel formation while also allowing increased trans-endothelial migration of cytotoxic immune cells, thereby reprogramming antitumor immunity. These vascular and immune-modulatory roles of MYCT1 offer exciting therapeutic opportunities, especially when combined with immunotherapeutic strategies."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "9"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its classical tumor suppressor functions, MYCT1 also influences cell migration and cytoskeletal organization through its transmembrane domain, which is indispensable for proper vesicle-associated localization. Patient-derived mutations disrupting this domain abolish its regulatory effects on cell viability and movement. In hepatocellular carcinoma, elevated levels of miR-632 reduce MYCT1 expression, promoting proliferation and invasion, while whole-exome sequencing studies in other diseases such as IgA nephropathy and investigations in vascular smooth muscle cells further imply a broader, pleiotropic role for MYCT1 in cellular homeostasis and disease pathogenesis."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "11", "end_ref": "15"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Guang-Bin Qiu, Li-Guo Gong, Dong-Mei Hao, et al. 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