{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nChromatin remodeling complexes broadly support transcriptional regulation and genomic stability; however, their specialized functions in specific cellular contexts are fine‐tuned by regulatory factors. One such factor is linc‑MYH, an evolutionarily conserved long non‑coding RNA that modifies the composition of the ubiquitous INO80 chromatin remodeler in muscle stem cells."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nLinc‑MYH exerts its regulatory influence by preventing the association of the INO80 complex with key co‑factors such as WDR5 and the transcription factor YY1. By selectively blocking these interactions, linc‑MYH functions as a molecular switch that enhances the pro‑proliferative activity of the complex without impairing its critical role in preserving genomic integrity."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nThis context‑dependent modulation is essential for balancing muscle cell states: linc‑MYH is expressed in proliferating myoblasts but not in quiescent muscle stem cells (MuSCs), thereby restricting the formation of quiescent MuSCs while promoting myoblast proliferation. Consequently, the extent of myoblast proliferation governed by linc‑MYH decisively influences the overall size of the quiescent MuSC pool, a balance that is crucial for efficient tissue homeostasis and regeneration."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Christian Schutt, Alix Hallmann, Salma Hachim, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Linc-MYH configures INO80 to regulate muscle stem cell numbers and skeletal muscle hypertrophy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "EMBO J (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.15252/embj.2020105098"}], "href": "https://doi.org/10.15252/embj.2020105098"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32960481"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32960481"}]}]}]}