{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRecent studies have advanced our understanding of non‐muscle myosin isoforms, with kinetic analyses of myosin IIA and IIB revealing that these molecular motors perform distinct roles in processes such as cytokinesis and cortical tension maintenance. In particular, non‐muscle myosin IIA exhibits a high actomyosin ADP affinity but spends only a brief period in strongly actin‐bound states relative to myosin IIB, suggesting that isoform-specific mechanochemical properties orchestrate fine-tuned cellular contractility."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn parallel, extensive investigations on the ubiquitin ligase RAD18 have delineated its multifaceted role in genome maintenance. RAD18 is recruited to both replication-associated lesions and meiotic double-strand breaks, where it not only facilitates postreplication repair but also assists in chromatin reorganization—such as the transcriptional silencing of unsynapsed chromosomal regions during male meiotic prophase—and contributes to cell cycle checkpoint regulation following DNA damage. In addition, RAD18 engages in regulatory cascades with translesion synthesis polymerases and even exerts a suppressive effect on viral infections, collectively underscoring its significance in both the preservation of genomic integrity and tumor suppression."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "3", "end_ref": "12"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nAlthough none of the provided studies address MYL7—the gene encoding a regulatory light chain of myosin—directly, insights from these reports offer a conceptual framework for its potential function. In settings where non-muscle myosin heavy chains are subject to mutation-induced defects, as observed in certain syndromes, compensatory interactions between isoforms (e.g., myosin IIA and IIB) have been reported; such cross-talk implies that associated regulatory light chains like MYL7 might similarly participate in fine-tuning motor function and stabilizing protein complexes."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "13"}]}, {"type": "t", "text": " Thus, while explicit evidence on MYL7 is presently lacking, these findings collectively suggest that MYL7 could be an important modulator of cytoskeletal dynamics, with roles in sustaining contractility and cellular integrity under both physiological and pathological conditions.\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Satoshi Tateishi, Hitoshi Niwa, Jun-Ichi Miyazaki, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Enhanced genomic instability and defective postreplication repair in RAD18 knockout mouse embryonic stem cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biol (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/MCB.23.2.474-481.2003"}], "href": "https://doi.org/10.1128/MCB.23.2.474-481.2003"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12509447"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12509447"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Mihály Kovács, Fei Wang, Aihua Hu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Functional divergence of human cytoplasmic myosin II: kinetic characterization of the non-muscle IIA isoform."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M305453200"}], "href": "https://doi.org/10.1074/jbc.M305453200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12847096"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12847096"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Roald van der Laan, Evert-Jan Uringa, Evelyne Wassenaar, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Ubiquitin ligase Rad18Sc localizes to the XY body and to other chromosomal regions that are unpaired and transcriptionally silenced during male meiotic prophase."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Sci (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1242/jcs.01368"}], "href": "https://doi.org/10.1242/jcs.01368"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15383616"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15383616"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Aliza G Lloyd, Satoshi Tateishi, Paul D Bieniasz, et al. 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